@GraefLab

We are interested in the #cell_biology of #autophagy, #mitochondria, and #ageing.

 Cornell University (+ MPI-Age)
age.mpg.de/science/research-laboratories/graef/
Joined January 2020
  • Tweets512
  • Following350
  • Followers1.3K
Include

Only show posts containing:

Exclude

Hide posts containing:

Time range
-
Minimum likes
Proud of new work tinyurl.com/yhz4c6ry from the lab by Zhicheng (Chen) Cui @Chen3dem using single-particle cryo-EM on liposomes to show how mTORC1 integrates nutrient and growth factor signaling at lysosomes, collab. w/ @G__Napolitano, A. Esposito, and A. Ballabio.
8
61
11
217
44,250
🎉 We're thrilled to share that our former colleague, @_mariyalicheva, now with the @GraefLab, received the prestigious Hans-Grisebach-Preis from @UniFreiburg for her dissertation! 🏅Congrats on this great achievement, Mariya! Photo credit: Universität Freiburg / Jürgen Gocke
3
1
1
8
1,157
Congratulations, Costas! Such a beautiful paper.
Demetriades Lab@DemetriadesLab9 Oct 2024
📢 I am so incredibly happy and proud about this one! 🔟+ years in the making, 2,5 years since first submission, 1⃣ year since we posted it @biorxivpreprint, it finally found it’s home @NatureCellBio! Open access 👇 nature.com/articles/s41556-0… Detailed 🧵down below ⏬
1
2
17
2,179
Graef Lab retweeted
Ragusa Lab@RagusaLab24 Sep 2024
Our work on the biochemical reconstitution of mitophagy initiation led by @Devika_An has been updated on bioRxiv. You can check it out at biorxiv.org/content/10.1101/…
9
28
2,697
🚨🚨Come join us! We’re searching for two assistant professor positions in cell and molecular biology, in collaboration with @CornellMBG! 👇
Cornell MBG@CornellMBG17 Sep 2024
Excited to announce an MBG faculty search for two assistant professor positions in collaboration with the Weill Institute for Cell and Molecular Biology, @weillinstitute. Please share and apply! academicjobsonline.org/ajo/j…
15
1
17
5,224
Excited to announce an MBG faculty search for two assistant professor positions in collaboration with the Weill Institute for Cell and Molecular Biology, @weillinstitute. Please share and apply! academicjobsonline.org/ajo/j…
17
2
17
10,040
We’ve worked out how the molecular machines that create acidic compartments can recruit autophagy (self-eating) machinery when they can’t maintain a pH gradient. We are really pleased with this discovery, out in @MolecularCell cell.com/molecular-cell/full…. 1/16

The V-ATPase/ATG16L1 axis is controlled by the V1H subunit

Timimi et al. reveal that the targeting of de-acidified compartments with ATG8s is mediated by a direct interaction between the V-ATPase subunit V1H and ATG16L1. This interaction is important for...

cell.com
8
45
2
129
25,750
Graef Lab retweeted
OsmanLab@osman_lab5 Aug 2024
🚀Excited to share our latest paper, where we explore dynamic changes in mtDNA heteroplasmy in living cells! Discover how asymmetric partitioning and mitochondrial dynamics drive mtDNA variant segregation! 🔬embopress.org/doi/full/10.10… #Mitochondria #microscopy #microfluidics #mtDNA

Real-time assessment of mitochondrial DNA heteroplasmy dynamics at the single-cell level

The EMBO Journal - Mitochondrial DNA (mtDNA) is present in multiple copies within cells and is required for mitochondrial ATP generation. Even within individual cells, mtDNA copies can differ in...

link.springer.com
2
24
7
59
6,502
Replying to @CGA_age @SNiftullayev @langer_lab @MPIAGE
Congratulations, Sadig! You did an amazing job in the @GraefLab and @langer_lab. More to come!
126
Huge congrats to Sadig @SNiftullayev who has successfully defended his doctoral thesis🥳✨🍻!!! #PhDone @MPIAGE @CGA_age
Cologne Graduate School of Ageing Research@CGA_age15 Jul 2024
🎉 Well done, Dr. Sadig Niftullayev! Today @SNiftullayev, CGA student of the class of 2018, supervised by @langer_lab @MPIAGE, excellently defended his PhD! 👨‍🎓 Time to celebrate 🍾 #PhDone
1
12
1,668
Can also find the paper on open access at @CellCellPress cell.com/cell/fulltext/S0092…

MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA...

MTFP1 prevents altered inner mitochondrial membrane subdomains from fusing with the healthier mitochondrial network, enabling their isolation and subsequent autophagic degradation. The findings...

cell.com
3
16
2,272
Eat less to live longer? #Autophagy degrades damaged or toxic cellular material to keep cells in good shape. We discovered how #ATG16L1 shapes phagophores. Our article was published today in @NatureSMB ! thanks to all the authors !! Check it out: nature.com/articles/s41594-0…
19
1
52
5,169
Beautiful work from the Lackner Lab as always!
American Society for Cell Biology@ASCBiology15 May 2024
From MBoC Temporal control of contact site formation reveals a relationship between mitochondrial division and Num1-mediated mitochondrial tethering. @LLLackner developed systems to control the formation and depletion of mitochondria-PM contact sites. doi.org/10.1091/mbc.E23-05-0…
5
878
Replying to @WestLabMito
Thank you for the wonderful visit. Great science and discussions!
197
🚨The Weill Institute is hiring a new faculty member!🚨 Assistant Professor position is now open in @weillinstitute, joint with @CornellMBG. This is an open search in all areas of molecular and cell biology; application deadline is 3/20. More info: academicjobsonline.org/ajo/j…
25
6
39
36,923
We are happy to share the publication below, which sheds light on the role of Atg1, Atg11 and Atg13 in bulk autophagy initiation. You can find the paper in the following link 👇 pubmed.ncbi.nlm.nih.gov/3823…
1
10
33
2,005
I am thrilled to see our work on the #Vacuole #LipidDroplet #MembraneContactSite vCLIP published in @Dev_Cell! Fantastic collaboration with @ruferbus and @schmidtlabIBK. Huge thanks to the whole team, I am so proud of you all! sciencedirect.com/science/ar…
12
29
2
95
12,037
Dynamin-like proteins at the nuclear envelope? That and other surprises in excellent work by @PhilipMannino1 with help from @NicholasAder @TJ_MeliaLab and @LuskingL! #autophagy biorxiv.org/content/10.1101/…

A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like...

Autophagic mechanisms that maintain nuclear envelope homeostasis are bulwarks to aging and disease. By leveraging 4D lattice light sheet microscopy and correlative light and electron tomography, we...

biorxiv.org
2
24
2
76
8,720
Graef Lab retweeted
JakobsLab@JakobsLab16 Feb 2024
The human prohibitin complex forms a bell-shaped structure in the inner mitochondrial membrane. Check out our #preprint together with @ratz_michael below 👇 biorxiv.org/content/10.1101/… What do you think it looks like? Like a bundt cake? A jellyfish? Vanilla pudding?😉
1
18
1
65
5,656
Replying to @ShoSuzuki20 @JCellBiol
Beautiful work as always, Sho!
1
1
116
Load more