@KraftLabFR

Research group led by Claudine Kraft at the @UniFreiburg. Our focus is on understanding the molecular mechanisms of #yeast and #mammalian #autophagy.

 Albert-Ludwigs-Universität
Joined May 2023
  • Tweets43
  • Following103
  • Followers207
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Read more about this research in our ‘First person’ interview with Riccardo Babic, Leon Lucya and Christoph Reiter: journals.biologists.com/jcs/…
Riccardo Babic (left), Leon Lucya (middle) and Christoph Reiter (right).

ALT Riccardo Babic (left), Leon Lucya (middle) and Christoph Reiter (right).

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Riccardo Babic, Leon Lucya, Christoph Reiter, Claudine Kraft and colleagues identify a ULK1–MTFR1L feedback loop that links mitochondrial fission, mitophagy and apoptosis. journals.biologists.com/jcs/…
Figure showing that fission factors localise to mitophagy initiation hubs.

ALT Figure showing that fission factors localise to mitophagy initiation hubs.

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#UniFreiburg vollzieht #eXit aus X. Der Account bleibt als Archiv sichtbar, neue Tweets wird es nicht geben. Wir setzen auf dezentrale Kurznachrichtendienste: Folgen Sie uns auf #Mastodon (xn--baw-joa.social/@unifreib…) & #Bluesky (@uni-freiburg.de)! Mehr dazu ufr.link/exit
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Kraft Lab retweeted
CIBSS@CIBSS_UniFR16 Jan 2025
#CIBSS is leaving X, this account will be archived and no longer updated. Follow us on #Bluesky and find us there as @cibss.bsky.social! More info on the #eXit of @UniFreiburg: uni-freiburg.de/en/the-unive…
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Big thanks to Chunmei Chang and Yi Lu for their insightful "News and Views" article on our recent paper! We really appreciate the way they explained our findings. 📰 You can read it here: nature.com/articles/s41556-0… And thanks, @NatureCellBio , for highlighting our work!

Boosting cargo turnover with receptor mobility

Nature Cell Biology - The clearance of biomacromolecules through selective autophagy is crucial for cellular homeostasis. A study now identifies receptor mobility as a key factor influencing cargo...

nature.com
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Kraft Lab retweeted
SFB 1177@sfb11778 Jan 2025
🔬 Excited to share the latest research findings of @sfb1177 members @KraftLabFR and @WilflingLab on the conditions required for the initiation of #autophagy. 🤝 @CIBSS_UniFR @NatureCellBio
The Wilfling Lab@WilflingLab7 Jan 2025
Our latest publication together with the @KraftLabFR, with a nice summary of the findings in this thread 🧵👇🏼
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Wie entsorgen Zellen Abfall? Forschende aus Freiburg @KraftLabFR @CIBSS_UniFR & Frankfurt @WilflingLab zeigen in @NatureCellBio, wie schwache Molekül-Wechselwirkungen #Autophagie auslösen – ein möglicher Schlüssel für die Forschung zu #Alzheimer & #Krebs. ufr.link/cibss-autophagie
Unter dem Fluoreszenzmikroskop: Das Molekül Atg11 (grün) bildet kleine Tröpfchen auf der Oberfläche eines Protein-Aggregats (blau). Bild: Mariya Licheva / Universität Freiburg

ALT Unter dem Fluoreszenzmikroskop: Das Molekül Atg11 (grün) bildet kleine Tröpfchen auf der Oberfläche eines Protein-Aggregats (blau). Bild: Mariya Licheva / Universität Freiburg

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🚨 Paper Alert! We’re starting off the year with our latest publication in @NatureCellBio on the role of phase separation in selective autophagy initiation! This work was a close and exciting collaboration with @WilflingLab 🔗 nature.com/articles/s41556-0… Here are the key findings👇
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🔑 In summary, we uncovered an unknown mechanism where Atg11/FIP200 phase separation drives initiation hubs formation for selective autophagy initiation in both yeast and mammals. Thanks to all collaborators & the first authors @_mariyalicheva, Jeremy, Riccardo, and @Hesktorplay
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📢 Check out the full paper here: nature.com/articles/s41556-0… And feel free to reach out for any questions or comments! #Autophagy #PhaseSeparation #CellBiology

Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy

Nature Cell Biology - Licheva, Pflaum, Babic, Mancilla et al. show that low-affinity cargo–receptor interactions promote autophagy receptor mobility and condensation of the scaffold protein...

nature.com
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Congrats @WilflingFlorian !
Max Planck Institute of Biophysics@MPIbp3 Dec 2024
Congratulations to the @WilflingLab for this incredible achievement! @WilflingFlorian is now an EMBO Young Investigator! 🧪🧪 biophys.mpg.de/2838711/flori… @EMBO
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Big congrats to Dr. Christopher Eickhorst for successfully defending his thesis on the role of FIP200 in autophagy! 🎓 So grateful to have Chris as a colleague and to have shared countless moments of scientific discovery together. 🔬 #Autophagy #CellBiology #AcademicResearch
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Kraft Lab retweeted
CIBSS@CIBSS_UniFR27 Oct 2024
Just over 2 weeks left to apply! Our highly collaborative and interdisciplinary Cluster of Excellence is looking for a new colleague with expertise in #cryoEM #structuralbiology and #signaling #facultypositions #professorship
CIBSS@CIBSS_UniFR8 Oct 2024
🚨 #JobAlert: W3 Professorship in Physical Chemistry with a focus on Cryo-Electron Microscopy. Join the Faculty of #Chemistry and #Pharmacy @UniFreiburg and contribute to cutting-edge research in the Cluster of Excellence #CIBSS. Apply by Nov 12, 2024! 👉 uni-freiburg.de/stellenangeb…
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Recruitment of autophagy initiator TAX1BP1 advances aggrephagy from cargo collection to sequestration | The EMBO Journal embopress.org/doi/full/10.10…

Recruitment of autophagy initiator TAX1BP1 advances aggrephagy from cargo collection to sequestra...

The EMBO Journal - Autophagy mediates the degradation of harmful material within lysosomes. In aggrephagy, the pathway mediating the degradation of aggregated, ubiquitinated proteins, this cargo...

link.springer.com
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🎉 We're thrilled to share that our former colleague, @_mariyalicheva, now with the @GraefLab, received the prestigious Hans-Grisebach-Preis from @UniFreiburg for her dissertation! 🏅Congrats on this great achievement, Mariya! Photo credit: Universität Freiburg / Jürgen Gocke
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Kraft Lab retweeted
CIBSS@CIBSS_UniFR14 Oct 2024
How do plants control their growth? A team of researchers @UniFreiburg led by CIBSS member Thomas Laux identified the HAN molecule as an important regulator of plant root growth in conjunction with WOX5. Published in @NaturePlants. 🌱 ➡️cibss.uni-freiburg.de/news/p…
The tip of a plant root under the (fluorescence) microscope. The cells in which WOX5 is active are marked in green. Image credit: Thomas Laux / University of Freiburg

ALT The tip of a plant root under the (fluorescence) microscope. The cells in which WOX5 is active are marked in green. Image credit: Thomas Laux / University of Freiburg

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