@Devika_An

Postdoc @Dartmouth

 Hanover
Joined May 2013
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  • Following305
  • Followers99
Happy to share my work from @hhiggs Lab in @ScienceAdvances. We reveal how the mitochondrial protein LACTB orchestrates inner-membrane remodeling to release death signals—offering a fresh angle on cancer cell survival @DartmouthBCB @Dartmouth science.org/doi/10.1126/scia…

The tumor suppressor LACTB remodels mitochondria to promote cytochrome c release and apoptosis

LACTB remodels the inner mitochondrial membrane during apoptosis to facilitate the release of cytochrome c and other factors.

science.org
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Happy to share my work from Higgs Lab @Dartmouth on BioRxiv! We show that LACTB—a filament-forming serine protease & tumor suppressor—is essential for apoptosis-induced IMM remodeling, promoting cytochrome c release. #Mitochondria #Apoptosis biorxiv.org/content/10.1101/…

The tumour suppressor LACTB remodels mitochondria to promote cytochrome c release and apoptosis

Mitochondria are pivotal regulators of cellular homeostasis, integrating energy metabolism, biosynthesis, and programmed cell death (apoptosis). During apoptosis, mitochondrial outer membrane...

biorxiv.org
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We get so focused on research it can be hard to take a step back and listen to other peoples stories. Check out @dartmouth postdoc @SukrutKamerkar's excellent perspective on supporting one another, published in @ScienceMagazine . science.org/content/article/…

I was consumed by my academic struggles—until a friend’s troubles put them in perspective

“Our challenges may all be different, but they are all real and important—if only we can truly listen,” this scientist writes

science.org
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Exciting news! 🌟 Explore the world of science with Jidnyasa Vigyaan. 🚀 Our videos, originally in Marathi, now in English too, aim to ignite curiosity in kids through fun experiments at home. Check out Glow in the Dark, DIY Microscope, and more at youtube.com/@jidnyasa.vigyaa…!
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Happy to share work from my postdoc on @biorxivpreprint where we reconstitute the first steps in mitophagy!
Ragusa Lab@RagusaLab20 Dec 2023
New paper up on bioRxiv biorxiv.org/content/10.1101/… Awesome work from @Devika_An demonstrating what types of tethering you can reconstitute with GUVs and liposomes in vitro. She also shows that Atg11 can bind some membranes and recruit them to Atg32 coated GUVs.
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Huge congratulations to these three awesome Ragusa Lab Ph.D. students who all returned to Hanover to participate in graduation last weekend. Congratulations Dr. Bauer, Dr. Leary and Dr. Reinhart!
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Super thankful to get to work with this amazing group of scientists every day in the lab.
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A huge congratulations to graduate student Kelsie Leary. Her watercolor painting now appears on the cover of this months Autophagy. You can checkout the current issue of Autophagy at tandfonline.com/toc/kaup20/c…
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From GSC President Irma Vlasac: On behalf of the Dartmouth Graduate Student Council, I write today to express the frustration and fear we feel as graduate students regarding the recent assault that occurred on Sunday September 19th (more in 🧵)
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Why sometimes history books need to be corrected…
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I am happy to share that my postdoc work in Roop Mallik's Lab just got published. Enjoyed developing a novel assay to mimic ER-LD contact in collaboration with @Jagjeet51992! Thank you @BSBEIitb @TIFRScience for supporting this work! Do check it out: pnas.org/doi/10.1073/pnas.22…

Metabolic and immune-sensitive contacts between lipid droplets and endoplasmic reticulum reconsti...

Coordinated cell function requires a variety of subcellular organelles to exchange proteins and lipids across physical contacts that are also refer...

pnas.org
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Have you ever wondered how your favorite #autophagy protein in yeast was shown to bind #membranes? Check out our new review summarizing this literature. Awesome work by graduate student Kelsie Leary summarizing all of this data. mdpi.com/2073-4409/11/12/187…
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Excited for our latest work showing membrane tethering by a coiled-coil protein Atg23! That’s two in a week for @RagusaLab! cell.com/cell-reports/fullte…

Dimerization-dependent membrane tethering by Atg23 is essential for yeast autophagy

Atg23 is an Atg9-interacting protein of unknown function required for selective autophagy and efficient nonselective autophagy. Hawkins et al. show that Atg23 is an extended dimeric membrane-binding...

cell.com
Ragusa Lab@RagusaLab19 Apr 2022
I am excited to announce another new paper from the lab which is out in @CellReports today. This paper was a wonderful collaboration with the Klionsky Laboratory. In it, we show that Atg23 is a coiled-coil tethering protein. cell.com/cell-reports/fullte…

Dimerization-dependent membrane tethering by Atg23 is essential for yeast autophagy

Atg23 is an Atg9-interacting protein of unknown function required for selective autophagy and efficient nonselective autophagy. Hawkins et al. show that Atg23 is an extended dimeric membrane-binding...

cell.com
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Happy to contribute in the latest work from @RagusaLab showing distinct membrane remodelling properties of SNX-BAR proteins. Congratulations Erin, Sarah and @KatieBauer93 !
Ragusa Lab@RagusaLab15 Apr 2022
Our newest paper exploring the membrane binding and remodeling properties of two related but distinct SNX-BAR complexes (Atg24/Atg24 and Atg20/Atg24) involved in autophagy is now online in @BiochemistryACS . pubs.acs.org/doi/10.1021/acs…

A Comparative Analysis of the Membrane Binding and Remodeling Properties of Two Related Sorting...

Abstract. The sorting nexin (SNX) proteins, Atg20 and Atg24, are involved in nonselective autophagy, are necessary for efficient selective autophagy, and a

pubs.acs.org
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Excited to share a part of my graduate work. In collaboration with @TPucadyil and @himanikhurrana !
Himani Khurana@himanidkhurana28 Feb 2022
Delighted to share our latest paper describing a pull-down strategy to analyse protein complexes on diffusible membrane bilayers supported on silica beads. An enriching collaboration with @Devika_An & @TPucadyil. Grateful for all feedback from the group! doi.org/10.1007/s00232-022-0…
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There's a new autophagy journal. Autophagy Reports is the sister journal of Autophagy and is open access. I am very excited to be part of the editorial board for this new journal. They are now accepting article submissions. think.taylorandfrancis.com/a…
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Dear @DrSJaishankar Sir, around 3000 medical students from 🇮🇳(approx 250-300 from #Jharkhand) are set to lose an academic year as they can’t return to Philippines due to the ban by @DFAPHL Plz help them resume their studies. @meaMADAD @indembmanila #TakeMedStudentsBackToPH
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We are Indian Medical Students Studying in Philippines, willing to go back to resume our classes, but we are unable to do so due to travel ban. Please help us to travel back to Philippines. Thank You 🙏🏻 @DrSJaishankar @shambhukumaran @indembmanila @meaMADAD @OIA_MEA @MEAIndia
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Exciting work by @SukrutKamerkar and others at Roop lab!
sukrut@SukrutKamerkar9 Jun 2021
Excited to share our recent work on reconstituting membrane contact sites between ER mimicking-supported bilayers & lipid droplets! We discovered how LD-ER contacts respond to animal metabolic state and immune activation. Out now on #biorxiv biorxiv.org/content/10.1101/…

In-vitro Reconstitution of Membrane Contact Sites between the Endoplasmic Reticulum and Lipid...

Coordinated cell function requires inter-organelle communication across Membrane Contact Sites (MCS). Here we deposit ER-enriched microsomes purified from rat liver or from cultured cells on a...

biorxiv.org
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Excited to share our recent work on reconstituting membrane contact sites between ER mimicking-supported bilayers & lipid droplets! We discovered how LD-ER contacts respond to animal metabolic state and immune activation. Out now on #biorxiv biorxiv.org/content/10.1101/…

In-vitro Reconstitution of Membrane Contact Sites between the Endoplasmic Reticulum and Lipid...

Coordinated cell function requires inter-organelle communication across Membrane Contact Sites (MCS). Here we deposit ER-enriched microsomes purified from rat liver or from cultured cells on a...

biorxiv.org
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