@osman_lab

Studying the mysteries that surround the genome of the cell's powerhouse

 Munich
cellbiology.bio.lmu.de/research_groups/osman/index.html
Joined November 2019
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  • Following246
  • Followers651
5Media
Thrilled to announce that our latest paper on the novel mitochondrial HMG-box protein, Cim1, just got published in @NAR_Open. academic.oup.com/nar/advance… Surprisingly, Cim1 antagonizes the TFAM homolog Abf2 in #mtDNA copy number regulation. Congrats, Simon!! #lmu #mitochondria 🔬

Two mitochondrial HMG-box proteins, Cim1 and Abf2, antagonistically regulate mtDNA copy number in...

Abstract. The mitochondrial genome, mtDNA, is present in multiple copies in cells and encodes essential subunits of oxidative phosphorylation complexes. mt

academic.oup.com
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OsmanLab retweeted
WELT
@weltOct 2
16-jährige Schülerin bricht während des Unterrichts zusammen und stirbt to.welt.de/2uWWpRu
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We have launched our new lab website 🥳. Every Mon/Thu, we drop an automated literature curation on #mtDNA quality control and copy number regulation. 📄 Detailed Briefing (PDF) 🎙️ #NotebookLM Podcast. osman-lab.de/

The Osman Lab | LMU Munich

Mitochondrial research and genome maintenance at Ludwig-Maximilians-University.

osman-lab.de
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How do cells assess mtDNA quality? Local ATP and membrane-potential gradients reflect mtDNA integrity and drive intracellular purifying selection. We introduce FAST, a scalable mtDNA QC assay in S. cerevisiae. journals.plos.org/plosgeneti…

Local mitochondrial physiology defined by mtDNA quality guides purifying selection

Author summary Mitochondria are essential organelles in our cells that convert nutrients into usable cellular energy. They contain their own DNA, and mutations in this DNA can compromise mitochondr...

journals.plos.org
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🚀 Excited to share our latest work on Mrx6 and mtDNA copy number regulation, now available on @biorxivpreprint ! We uncover how Mrx6 and Mam33 interact with the Lon protease Pim1 to control substrate degradation. 🔬 Check it out here: biorxiv.org/content/10.1101/… #mitochondria #mtDNA

Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and...

Mitochondrial DNA (mtDNA) copy number regulation remains incompletely understood, despite its importance in cellular function. In Saccharomyces cerevisiae , Mrx6 belongs to the Pet20-domain-contain...

biorxiv.org
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Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number biorxiv.org/content/10.1101/… #biorxiv_cellbio

Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and...

Mitochondrial DNA (mtDNA) copy number regulation remains incompletely understood, despite its importance in cellular function. In Saccharomyces cerevisiae , Mrx6 belongs to the Pet20-domain-contain...

biorxiv.org
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🚨 New segmentation model alert! 🚨🥳 You can finally use InstanSeg in our #BioImageAnalysis software #CellACDC! InstanSeg is a fast and multi-channel cell segmentation model by @petebankhead, Thibaut Goldsborough, & co. The multi-channel ability is very interesting!
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It is not trivial to make the right amount of histones in different nutrients, when #cellsize, growth rate, and S-phase duration change. Still, budding yeast manages by regulating transcription and translation: doi.org/10.1038/s44318-024-0… @frank_pado

Decoupled transcript and protein concentrations ensure histone homeostasis in different nutrients

The EMBO Journal - To maintain protein homeostasis in changing nutrient environments, cells must precisely control the amount of their proteins, despite the accompanying changes in cell growth and...

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Huge thanks to @anjbadri and @nitish_dua3 for spotlighting our work in @embojournal ! 🙏🧬 Check out the full article here 🚀🔬 embopress.org/doi/full/10.10… #mtDNA #mitochondria
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Disordered regions in the IRE1α ER lumenal domain form condensates in vitro and mediate its stress-induced clustering and signaling in cells Elif Karagöz @gekaragoz @MaxPerutzLabs and coworkers embopress.org/doi/full/10.10…
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Glad to share this little piece referring to last paper published in @Nature by Prashar et al. Selective degradation of mitochondrial inner membrane through direct transfer to lysosomes @NatureNV @AndreasReicher8 @ReichertLab nature.com/articles/d41586-0…

Inner membrane turns inside out to exit mitochondrial organelles

Nature - Pathway selectively removes inner membrane from mitochondrial organelles.

nature.com
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Grateful to everyone who contributed and beyond excited to share my work with you!
The EMBO Journal@embojournal6 Aug 2024
Real-time assessment of yeast heteroplasmy dynamics at the single-cell level: Asymmetric partitioning during cell division & limited mitochondrial fusion/fission frequencies drive mtDNA variant segregation @osman_lab @LMU_Muenchen embopress.org/doi/full/10.10…
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Introducing a resource of mtDNA copy number (mtCN) across ~10k human donor-tissues (GTEx), 20 murine tissues, and 173 cancer cell lines. Insights emerge by integrating mtCN w/other large-scale measures, e.g., DepMap cells w/high mtCN resist loss of GPX4. pnas.org/doi/10.1073/pnas.24…

Mitochondrial genome copy number variation across tissues in mice and humans | PNAS

The mammalian mitochondrial genome (mtDNA) is multicopy and its copy number (mtCN) varies widely across tissues, in development and in disease. Her...

pnas.org
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Real-time assessment of yeast heteroplasmy dynamics at the single-cell level: Asymmetric partitioning during cell division & limited mitochondrial fusion/fission frequencies drive mtDNA variant segregation @osman_lab @LMU_Muenchen embopress.org/doi/full/10.10…
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It was an absolute pleasure to collaborate on this, fantastic work lead by @RoussouRo. I'm very happy to see that our #BioimageAnalysis software #CellACDC was useful to analyse these fantastic images @SchmollerLab
OsmanLab@osman_lab5 Aug 2024
🚀Excited to share our latest paper, where we explore dynamic changes in mtDNA heteroplasmy in living cells! Discover how asymmetric partitioning and mitochondrial dynamics drive mtDNA variant segregation! 🔬embopress.org/doi/full/10.10… #Mitochondria #microscopy #microfluidics #mtDNA

Real-time assessment of mitochondrial DNA heteroplasmy dynamics at the single-cell level

The EMBO Journal - Mitochondrial DNA (mtDNA) is present in multiple copies within cells and is required for mitochondrial ATP generation. Even within individual cells, mtDNA copies can differ in...

link.springer.com
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🚀Excited to share our latest paper, where we explore dynamic changes in mtDNA heteroplasmy in living cells! Discover how asymmetric partitioning and mitochondrial dynamics drive mtDNA variant segregation! 🔬embopress.org/doi/full/10.10… #Mitochondria #microscopy #microfluidics #mtDNA

Real-time assessment of mitochondrial DNA heteroplasmy dynamics at the single-cell level

The EMBO Journal - Mitochondrial DNA (mtDNA) is present in multiple copies within cells and is required for mitochondrial ATP generation. Even within individual cells, mtDNA copies can differ in...

link.springer.com
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Just wrapped up an amazing retreat at Schloss Ringberg🤩! With fantastic guest speakers/lab alumni, we enjoyed discussing all our exciting projects, hiking, and playing games in this cosy place🍻☀️! #LabLife #scienceretreat #mitochondria #researchlife #science
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Just back from a wonderful retreat with the @osman_lab in Tjärnö on the Swedish west coast @GothenburgMBL. Three days of scientific discussions around mitochondrial gene expression and maintenance, beautiful scenery and lots of fun. Thanks to everybody for the good times!!
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Awesome fun activity at the retreat with the @Ott_MitoLab at Tjärnö Marine Station 🔬🪸🪼🦀🦭
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