@RagusaLab

Research laboratory @DartmouthChem utilizing structural biology, biochemistry and cell biology to investigate the molecular mechanisms of selective autophagy.

Joined July 2015
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  • Followers261
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The RagusaLab is now on Bluesky. Come check us out at bsky.app/profile/ragusalab.b…
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Our new preprint is out: we solved the structures of HIV-1 matrix (MA) from intact virions by SPA. The structure led us to a surprising discovery resolving a long mystery in HIV-1 biology – peptide SP2 regulates the maturation of the HIV-1 matrix. 🧵1/x tinyurl.com/c7szhtfa
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We get so focused on research it can be hard to take a step back and listen to other peoples stories. Check out @dartmouth postdoc @SukrutKamerkar's excellent perspective on supporting one another, published in @ScienceMagazine . science.org/content/article/…

I was consumed by my academic struggles—until a friend’s troubles put them in perspective

“Our challenges may all be different, but they are all real and important—if only we can truly listen,” this scientist writes

science.org
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It's known that anionic lipid charge enhances alpha-synuclein's ability to bind membranes. But did you know that alpha-synuclein can preferentially bind to neutral membranes when they are full of packing defects? Read about it in our latest preprint!
bioRxiv Biophysics@biorxiv_biophys16 Nov 2024
Lipid Packing Defects are Necessary and Sufficient for Membrane Binding of alpha-Synuclein biorxiv.org/cgi/content/shor… #biorxiv_biophys
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Come check us out at booth 1131 for a research-immersive trainee-focused postbac program with an emphasis on wellbeing! @ABRCMS!! #ABRCMS
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Pleased to see our paper now published in Autophagy Reports! Great work from all involved to discover more about how "protein ATG8ylation" works. The big question is still "why?" "ATG5 is dispensable for ATG8ylation of cellular proteins" tandfonline.com/doi/full/10.…
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Come be my colleague! @DartmouthChem has an opening for an Associate/Full Professor in Materials Chemistry: apply.interfolio.com/152869
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Our work on the biochemical reconstitution of mitophagy initiation led by @Devika_An has been updated on bioRxiv. You can check it out at biorxiv.org/content/10.1101/…
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New paper up on bioRxiv biorxiv.org/content/10.1101/… Awesome work from @Devika_An demonstrating what types of tethering you can reconstitute with GUVs and liposomes in vitro. She also shows that Atg11 can bind some membranes and recruit them to Atg32 coated GUVs.
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Can you reconstitute tethering using three-color imagining to monitor protein localization at tethering sites in vitro? Yes! Can you distinguish between membrane binding and tethering with a single assay? Yes! Can you monitor tethering in real-time? Yes!
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I am very happy our DFCP1 story is out! Since many years, DFCP1 has been used as an omegasome marker, but its function was totally unknown. Here we show that DFCP1 is an ATPase required for selective autophagy. Here are the main points of the paper: 1/8
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Excited to announce that the Gonzalez Lab (chem-gonzalezlab.com) will open its doors when I join @DartmouthChem as an Assistant Professor of Chemistry in Fall 2023! (1/3)

Gonzalez Lab

Inorganic, materials, and supramolecular chemistry lab at Dartmouth

chem-gonzalezlab.com
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Very happy to see our paper now online. Great work from Wenxin, Taki and our fantastic colleagues #autophagy #crick @wencyzh @Sci_Lipi doi.org/10.7554/eLife.89185 @eLife
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Huge congratulations to these three awesome Ragusa Lab Ph.D. students who all returned to Hanover to participate in graduation last weekend. Congratulations Dr. Bauer, Dr. Leary and Dr. Reinhart!
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Have a Ph.D. in organic chemistry but want to gain experience applying data science to reaction development? The Read Lab @DartmouthChem is hiring a postdoc! See readlaboratory.com for more info. Please RT. #chempostdoc
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Our paper is out! Congratulations to @Cassandra_Hayne @TheHayneLab @RobinStanleyLab at @NIEHS ! I had fun image processing this project! nature.com/articles/s41594-0…
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Super excited to share a review article by @Nguyen_T_Hieu and myself on Substrate and phosphorylation site selection by PPPs! sciencedirect.com/science/ar…
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.@tjolivas, Yumei Wu, @shenliang_yu, @TJ_MeliaLab et al. @YaleCellBio show that ATG9 vesicles are the membrane seed for mammalian autophagosomes using nanodisc technology bit.ly/3LBlFg4 @PDClab @GuptaLab1 @1in_1uan @em_guinn @ShantaNag1 #autophagy
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Ragusa Lab retweeted
Graef Lab@GraefLab28 Apr 2023
Here is the upated article from our lab, published today. Great job @DabrowskiRahel and @susanna_tulli !
Rahel Dabrowski@DabrowskiRahel28 Apr 2023
🚨 I’m thrilled to announce that my PhD paper has just been published in @JCellBiol🥳🚨 We find that parallel phospholipid transfer by Vps13 and Atg2 determines the dynamics of autophagosome biogenesis 🍩 #Autophagy @GraefLab @UniCologne @Wautophagy rupress.org/jcb/article/222/… 1/8
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🚨 Thesis Seminar Alert: Daniel Walsh (Supattapone Lab) will present his research today at 11am in Chilcott and on Zoom!
BCBDartmouth@DartmouthBCB25 Apr 2023
Daniel Walsh will be delivering his PhD Thesis Presentation TODAY at 11:00 am. Join us in Chilcott Auditorium or online via Zoom. geiselmed.dartmouth.edu/bioc…
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