@Weipeg

PI of structural biology and former member@UPenn@Marmorstein Lab

 Philadelphia, PA
Joined July 2014
  • Tweets47
  • Following177
  • Followers63
Excited to share our latest preprint on human FATP2! Cryo-EM structures reveal mechanisms of fatty acid uptake, activation, and inhibition. Congrats to all co-authors! biorxiv.org/content/10.64898…

Mechanism of fatty acid uptake and inhibition in human FATP2

Fatty Acid Transport Protein 2 (FATP2) couples fatty acid uptake to intracellular activation and is associated with pathological lipid accumulation in cancer and nonalcoholic fatty liver disease....

biorxiv.org
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Excited to share our new preprint: Structural assemblies for an RNA world. We show that short RNAs can self-assemble into protein-like architectures, including closed cages, finite oligomers, and filaments. biorxiv.org/content/10.64898…
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We have a new paper out from the Marmorstein Lab in @Nature! Read it here: pubmed.ncbi.nlm.nih.gov/3997…
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Who is your Twitter twin? 👯 @Weipeg = @jxzhang8 Weipeg and jxzhang8 are Twitter twins! #twitterTwin #toasteed toasteed.com/dk4mr1/pfwn8tim
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Xuepeng Wei retweeted
Qiang Guo@QiangGuo_EM2 Feb 2023
Amazing work from Sui Lab. I saw lots of people curious about the methodology part, and I happen to know something about this. The method used is developed by Xinzheng Zhang lab. pubmed.ncbi.nlm.nih.gov/3463…

Determining structures in a native environment using single-particle cryoelectron microscopy images...

Cryo-electron tomography is a powerful tool for structure determination in the native environment. However, this method requires the acquisition of tilt series, which is time-consuming and severely...

pubmed.ncbi.nlm.nih.gov
Hideaki E. Kato@emeKato1 Feb 2023
new release3 7Y5E: In situ single-PBS-PSII-PSI-LHCs megacomplex. (3.30Å) You, X., Zhang, X., Cheng, J., Xiao, Y.N., Sui, S.F. In situって書いてあるけど、reconstruction methodが"single particle"と書いてあるのでSPAかな？ （それでも3.3Åは凄い）
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Transitioning from a post-doc fellowship to PI of a lab...
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Cryo-EM structure of an active central apparatus nature.com/articles/s41594-0…

Cryo-EM structure of an active central apparatus

Nature Structural & Molecular Biology - Here, authors solve cryo-EM structures of the central apparatus of motile cilia and analyze its dynamic conformations to elucidate the mechanism of...

nature.com
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Ever wonder how the enzyme responsible for the final step in synthesis of outer leaflet of gram negative bacteria looks? No…then don’t worry, most people haven’t 😝 However, if you are intrigued then why not check out our latest #cryoEM structure out in @Nature today 🦠
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Xuepeng Wei retweeted
Huigang Shi@Huigang_Shi6 Apr 2022
An electron counting algorithm improves imaging of proteins with low-acceleration-voltage cryo-electron microscope disq.us/t/46m9ajy
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Meet the author: Kenji Murakami @BMBGGUPENN @BB_UPenn cell.com/molecular-cell/full…

Meet the author: Kenji Murakami

Here, we talk to group leader Kenji Murakami, lead author of “Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II,” about the research in his...

cell.com
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We are pleased to share our structure with the community. PDBs also available!
Carter Lab@Carter_Lab31 Jan 2022
A stunning & comprehensive structural tour of the active cilia central apparatus by @zhang_lab - not only shows organisation of projection & bridge proteins but also captures arrays of kinesins (in different stepping states!) #journalclub biorxiv.org/content/10.1101/…
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Many congratulations Yang! Extremely happy for you 🎉
Yang Yang@yyang_cella14 Jan 2022
Thrilled to see our @ScienceMagazine paper is out now! Great thanks to @MichelGoed @SjorsScheres @bwfalcon @GhettiBernardi1 and the whole team. Happy to work with @DianaArseni and @wjzhwed to make this happen. science.org/doi/10.1126/scie…

Cryo-EM structures of amyloid-β 42 filaments from human brains

In Alzheimer’s disease and other conditions, two structurally related protofilaments form type I and type II Aβ42 filaments.

science.org
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Tomorrow, 12/7 at 12pm ET, don't forget to join us as Prof. @SjorsScheres @MRC_LMB presents on "New developments in RELION-4.0." Webinar connection details: buff.ly/33CKYqu
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Here, led by @paultkim_nysbc, @Anchi2Cheng, & @tbepler1, we present Ptolemy, open-source software for automated cryoEM collection. Squares and holes are automatically identified and ranked based on machine learning and computer vision algorithms that generalizes well to new data.
cryoEM Papers@cryoEM_Papers6 Dec 2021
Learning to automate cryo-electron microscopy data collection with Ptolemy. arxiv.org/abs/2112.01534
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Our new NLRP3 paper from talented Liudmila @LiudmilaLAN, Liron @LironDavid2, Shaun, Chen @Chen_Shen_01 and Prof. Pablo @PelegrinPablo - double-ring cage that hides the effector domain but sits on trans-Golgi to sense disturbance. New drug target! cell.com/cell/fulltext/S0092…
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SLC25A1 promotes tumor growth and survival by reprogramming energy metabolism in colorectal cancer nature.com/articles/s41419-0…
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Near atomic structure of the inner ring of the Saccharomyces cerevisiae nuclear pore complex biorxiv.org/cgi/content/shor…
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Congrats 🎉🎉🎉
Hanting Yang (杨涵婷)@Hanting_Yang26 Oct 2021
Time to announce I will start my own lab at Fudan University in Shanghai. Today is my last day at @MRC_LMB, beyond grateful to my mentors and colleagues helped me along the way, I will soon be recruiting postdocs so if you are interested in mitochondria, get in touch! #newPI
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Congrats to my PhD collaborator.
Huigang Shi@Huigang_Shi13 Oct 2021
A nice paper from my Ph.D. lab. Structure of Venezuelan equine encephalitis virus with its receptor LDLRAD3 disq.us/t/41xrkrz
Xuepeng Wei retweeted
Yang Shi@sy3180230 Sep 2021
Excited to see our paper is out. Many thanks to ⁦@SjorsScheres⁩ ⁦@MichelGoed⁩ ⁦and team. Finishing the last challenging pieces of the puzzle provides us overarching perspectives on tauopathy codes which are made of misfolded tau proteins. nature.com/articles/s41586-0…
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