@ShorterLabGroup

We are a group of scientists @Penn working to combat protein misfolding as a way to understand and treat neurodegenerative diseases. (student run)

 Philadelphia, PA
med.upenn.edu/shorterlab/index.html
Joined October 2012
  • Tweets12.8K
  • Following1.6K
  • Followers3.1K
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Shorter Lab Members retweeted
ShorterLab@ShorterLab14 Dec 2023
Happy holidays from the Shorter lab! – at Philadelphia, PA
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Aggregate
@AggregateOA22 Dec 2022
Early View💡 "A dual-functional BODIPY-based molecular rotor probe reveals different viscosity of protein aggregates in live cells" by He Huang, Yu Liu & Xin Zhang et al. @kfzhangxin @dicp_cas @Wiley_Chemistry #BODIPY #viscosity #protein #aggregate Check👉doi.org/10.1002/agt2.301
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Multi‐Step Molecular Mechanism of Amyloid‐Like Aggregation of Nucleic Acid‐Binding Domain of TDP‐43 onlinelibrary.wiley.com/doi/…

Multistep molecular mechanism of amyloid‐like aggregation of nucleic acid‐binding domain of TDP‐43

TDP-43 protein is associated with many neurodegenerative diseases and has been shown to adopt various oligomeric and fibrillar states. However, a detailed kinetic understanding of the structural...

onlinelibrary.wiley.com
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Human J-Domain Protein DnaJB6 Protects Yeast from [PSI+] Prion Toxicity mdpi.com/2014680

Human J-Domain Protein DnaJB6 Protects Yeast from [PSI+] Prion Toxicity

Human J-domain protein (JDP) DnaJB6 has a broad and potent activity that prevents formation of amyloid by polypeptides such as polyglutamine, A-beta, and alpha-synuclein, related to Huntington’s,...

mdpi.com
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Shorter Lab Members retweeted
🔬 R-loop@R_loop_papers19 Dec 2022
Roles of RNA-binding proteins in neurological disorders, COVID-19, and cancer dlvr.it/Sfb0y7

Roles of RNA-binding proteins in neurological disorders, COVID-19, and cancer - PubMed

RNA-binding proteins (RBPs) have emerged as important players in multiple biological processes including transcription regulation, splicing, R-loop homeostasis, DNA rearrangement, miRNA function,...

pubmed.ncbi.nlm.nih.gov
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Shorter Lab Members retweeted
ShorterLab@ShorterLab19 Dec 2022
Multivalency ensures persistence of a +TIP body at specialized microtubule ends: nature.com/articles/s41556-0…
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Shorter Lab Members retweeted
ShorterLab@ShorterLab21 Dec 2022
Mechanisms of DNA opening revealed in AAA+ transcription complex structures: science.org/doi/10.1126/scia…

Mechanisms of DNA opening revealed in AAA+ transcription complex structures

cryoEM structures reveal DNA opening by a protein peptide threading through the DNA double helix in transcription initiation.

science.org
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A fond *fare*well to Dr.@CharlotteFare! We are excited to see what you do next @HopkinsMedicine 👩‍🔬✨
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Shorter Lab Members retweeted
UMich Diversity
@UMichDiversity20 Dec 2022
Kyla McMullen, the only Black American woman who has earned a PhD in computer science and engineering from U-M, has launched Modern Figures, a podcast that elevates the voices of Black women in computing. myumi.ch/P1Jjd | #UMichDEI

Not hidden but modern

U-M's only Black American woman to graduate with a PhD in computer science and engineering is driving change within the University of Florida and scaling her influence with a podcast.

news.engin.umich.edu
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FUNDC1 Promotes Mitochondrial Translocation of TDP-43 and Modulates TDP-43 Induced Neurotoxicity papers.ssrn.com/sol3/papers.…
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Shorter Lab Members retweeted
YingZhu@NanoPOTS_SCP20 Dec 2022
I am excited to share I have formally joined Genentech as Senior principal scientist and group lead of #singlecell and #spatialproteomics. We have several positions opening now. Dear friends, please help to spread the messages. careers.gene.com/us/en/searc…
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Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation go.nature.com/3Wx1OBe This new review covers insights into the pathophysiology of ALS, advances in disease modelling, the current landscape of clinical trials and more
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Shorter Lab Members retweeted
Nat Rev Neurology@NatRevNeurol21 Dec 2022
Proteomic clusters underlie heterogeneity in preclinical Alzheimer’s disease progression academic.oup.com/brain/advan…

Proteomic clusters underlie heterogeneity in preclinical Alzheimer’s disease progression

Wisch et al. use machine learning to assess longitudinal changes in Alzheimer’s disease biomarkers—including CSF, PET and MRI measures—in older individuals

academic.oup.com
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Shorter Lab Members retweeted
Sabareesan A T@ATsabareesan20 Dec 2022
(1/1) Proudly present our recent work on small molecule partitioning into Biomolecular condensates. biorxiv.org/content/10.1101/…

Small Molecule Properties Define Partitioning into Biomolecular Condensates

Biomolecular condensates regulate cellular function by compartmentalizing molecules without a surrounding membrane[1][1],[2][2]. Condensate functions are believed to arise from the specific exclusion...

biorxiv.org
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Shorter Lab Members retweeted
JSDavis@jscdavis20 Dec 2022
Attn: #HBCU #MSI faculty and trainees! Join us on January 12, 2023, for a hybrid presentation of how to bring cryoEM to your lab/institution, start a new collaboration or send your samples to one of the national cryoEM centers. @BlackinBiophys
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Attn: Undergrads! Interested in biomed research? @PennMedicine offers an immersive summer research program #PennSUIP & a fantastic post-bacc program #PennPrep! 🔬🧬 To learn more, join us 1/12/23 (12-1p ET) or 1/16/23 (6-7p ET): tinyurl.com/SuipPrep #phdchat @IDEAL_research
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Shorter Lab Members retweeted
ShorterLab@ShorterLab19 Dec 2022
Multivalent interactions facilitate motor-dependent protein accumulation at growing microtubule plus-ends: nature.com/articles/s41556-0…
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Very pleased that our paper "Mechanistic insights into monomer level prevention of amyloid aggregation" is online now. sciencedirect.com/science/ar…
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A mass spectrometry-based approach for the identification of Kpnβ1 binding partners in cancer cells rdcu.be/c1XQP
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