@WuLabHarvard

Asa and Patricia Springer Professor of Structural Biology @ Harvard Medical School and Boston Children’s Hospital. #immunology #structure_biology

 Boston, MA
wulab.tch.harvard.edu
Joined March 2019
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  • Followers6.1K
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Our new paper by postdoc Man Wu @manwu381774343 "The centrosomal hub unifies regulatory factors of NLRP3 inflammasome activation" provides a simple, unified insight on this complicated beast of NLRP3 inflammasome! pnas.org/doi/10.1073/pnas.26…
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Ever wondered why only inflammasomes that use ASC, but not those that do not use ASC, can mature IL-1β? ASC helps to recruit pro-IL-1β to ASC for caspase-1 processing! See: "Inflammasome adaptor protein ASC is a mechanistic checkpoint in IL-1β maturation" pnas.org/doi/10.1073/pnas.25…

Inflammasome adaptor protein ASC is a mechanistic checkpoint in IL-1β maturation | PNAS

Inflammasome activation triggers caspase-1-dependent maturation of pro-interleukin-1β (pro-IL-1β) in an apoptosis-associated speck-like protein con...

pnas.org
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I’m so excited and proud that my student Jennifer Wang @Jennnwww has received so many kudos for her Master’s thesis talk in Immunology @harvardmed! @ShivPillai4 Congratulations, Jennifer! @Luochen_Liu1 @jf033 @ZhoupingH @AhmetBugraTufa2 @PiXiong_3 @L_Heals
🤖 Made with AI
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Excited to share our paper on the NLRP3 inflammasome condensate at the MTOC by "precise!" cryo-electron tomography (cryo-ET), in collaboration with Jue (phyllis) Wang@Phyllis23382012in the labs of Grant Jensen (BYU) and Pete Dahlberg (Stanford)! science.org/doi/10.1126/scia…

Human NLRP3 inflammasome activation leads to formation of condensate at the microtubule organizing...

Cryo-ET reveals that the NLRP3 inflammasome in human macrophages forms a condensate that disrupts the MTOC.

science.org
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Excited to share an amazing video on the NLRP3 inflammasome pathway generated by talented Ann from the Iwasa lab @janetiwasa @Ann_HuiLiu. It shows the real cryo-EM structures of the pathway from #NLRP3, #ASC, #caspase-1, #GSDMD, #IL-1b, to #NINJ1. #cryoem @LeXiao17 Enjoy
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Prof. Hao Wu retweeted
Massimo
@Rainmaker1973Mar 3
Weight makes a difference ᵃᶦ
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Excited to share an atlas and paper by summer interns depicting filament-forming proteins @ank_kan_95! They contain the most prevalent domains (e.g. DD, CARD, PYD) in innate immunity. #inflammasome #StructuralBiology #AlphaFold deathdomain.org/ pnas.org/doi/10.1073/pnas.24…
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What an exciting news and a huge honor! Our 2014 paper on ASC-PYD inflammasome filaments (Lu et al., Cell) has been recognized as a landmark in Cell’s "2014–2024 Timeline"! 🔥🔥🔥 #Inflammasome #PYD #StructuralBiology 🔗 cell.com/action/showPdf?pii=…
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🎉🎉🎉 Professor Jia-huai Wang's new book, Proteins: A Structural Biology Perspective, is now out from Academic Press! 📖 Dive into the evolution of structural determination and AlphaFold! #StructuralBiology #Proteins #AlphaFold amazon.com/Proteins-Structur…

Proteins: A Structural Biology Perspective

Proteins: A Structural Biology Perspective

amazon.com
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From bold resolutions, to big breakthroughs, CRI scientists including CRI Tech Impact Award Grantee Dr. Rik G.H. Lindeboom @NKI_nl are aiming to advance cancer research in many ways throughout 2025. Discover more New Year's resolutions in our newest blog: bit.ly/42ddE9V
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Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Tweetorial (1/13)👇with movies! Link: rdcu.be/d2mjm
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BREAKING: President Biden will become the first President in American history to register job growth in every single month during his Presidency. This is huge.
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I voted by mail today! Everyone should exercise their duty - there is no excuse that is big enough to justify not to vote.
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What’s better than going to a local symposium with only talks by students and postdocs? 9th SoCal cryo-EM symposium yesterday: dornsife.usc.edu/bridge-inst… amongst @CorneliusGati, Juli Feigon @FeigonLab, Hong Zhou, Dillon Cogan and Angie Walker. So fun to interact with trainees!
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BREAKING: In a stunning moment at an event focused on fighting antisemitism, Donald Trump just announced that Jewish Americans need to have their head examined. Retweet so all Americans see this and know how vile Trump is.
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BREAKING: Teamsters from Nevada and Michigan have just announced they are endorsing Kamala Harris. This is huge.
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BREAKING: In a stunning leak, Donald Trump gave the keynote address at the Heritage Foundation where he announced the work the foundation did (Project 2025) would be crucial to his policy goals. Retweet so all Americans know Trump will enact Project 2025.
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BREAKING: In a stunning admission, one of the most conservative Senators, Senator James Lankford, admits that it was Donald Trump who sabotaged the toughest border security legislation proposed in decades. Retweet to make sure every American sees this.
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Prof. Hao Wu retweeted
Veit Hornung@v_hornung6 Sep 2024
We’ve just finalized the program for our EMBO Inflammasome Workshop. 🙌 Next to many amazing short talks, we have an incredible lineup of poster presentations featuring lots of unpublished work. Check out the full agenda on our website—there’s still time to register! 👇
Veit Hornung@v_hornung21 Apr 2024
Our official poster is out 🪧 EMBO workshop "The inflammasomes - 2024". September 24 - 27, 2024 | Planegg-Martinsried, Germany - 4 keynote lectures - 20 talks - 15 short talk slots - many networking opportunities - 🎡 & 🥨 & 🍻 Register here 👇 meetings.embo.org/event/24-i…
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BREAKING: Mike Pence has just announced that he cannot in good conscience vote for Donald Trump. Retweet to make sure every American sees this clip.
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