@Carter_Lab
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Joined August 2015
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Check out this stunning animation by @janetiwasa (in collaboration with @SamReckPeterson), showcasing our model of how various components come together to form active dynein complexes capable of transporting cellular cargo.
Our work on how the lysosomal adaptor JIP3, and regulator LIS1 activate the dynein motor protein is now out in @ScienceMagazine ! science.org/doi/10.1126/scie…
Many thanks to our reviewers and editor for their valuable input.
Excited to share our latest work with the bullock lab! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
biorxiv.org/content/10.1101/…
Check out this exciting new study led by @teix_vanessa revealing that CDR2 is a dynein adaptor and regulates ER sheet organization!!
My PhD work is finally out in @JCellBiol! 🎉
Reach out if you want to know more 😉
Carter Lab retweeted
My PhD work is finally out in @JCellBiol! 🎉
Reach out if you want to know more 😉 – at Póvoa de Varzim, Portugal
Teixeira et al @i3S_UPorto identify the onconeural antigen CDR2 as ER-localized adaptor for the microtubule-based motor cytoplasmic dynein-1 & show that CDR2 contributes to ER organization thru. its interaction w/ the integral ER membrane protein kinectin hubs.la/Q03wGLyX0
A one day meeting on Friday 6th December covering all aspects (and scales) of Structural Biology.
Lots of talk slots to be selected from abstracts.
Deadline for abstracts is this Friday (15th Nov).
bit.ly/4fDEqfZ
Today at #journalclub we looked at the structure of tubulin acetyletransferase bound to the microtubule lumen nature.com/articles/s41594-0…
A fantastic paper describing a novel mechanism of selective inner mitochondrial membrane removal guided by lysosomal-mitochondrial communication (Dr. Akriti Prashar, @NicolaJGI) #JournalClub nature.com/articles/s41586-0…
Would you like to work in the MRC-LMB EM facility?
mrc.tal.net/vx/mobile-0/appc…
Carter Lab retweeted
Our paper looking at the structure of retrograde IFT trains is out now! Have a look at the link, or see some of the headlines in this video:
cell.com/cell/fulltext/S0092…
Today at #journalclub we learned how bacteria protect themselves against phage infection by conjugating ubiquitin-like proteins to the phage tails 🤯 nature.com/articles/s41586-0….
My first PhD student, Emma Hanford (nee Gleave), made some cysteine-lite dynein constructs in 2013. 11 years later, thanks to MinFlux, Joseph Slivka and @Yildiz_Lab they have been used in a nice biorxiv paper. doi.org/10.1101/2024.07.16.6…
Today in Journal Club - Cross-link assisted spatial proteomics to map sub-organelle proteomes and membrane protein topologies nature.com/articles/s41467-0…
Carter Lab retweeted
We're thrilled to share our new preprint: "Evolutionarily Conserved Principles of ESCRT-III-Mediated Membrane Remodeling Revealed by a Two-Subunit Asgard Archaeal System."
biorxiv.org/content/10.1101/…
Today in #journalclub, we discussed the fascinating molecular infrastructure of glutamatergic synapses biorxiv.org/content/10.1101/…
Great work from the Dodding and Woolfson labs showing how a designed peptide can activate kinesin in vitro and in cells #journalclub
Great to see our work on manipulating kinesin-1 activity using protein design led by @jessica_a_cross in print. In collaboration with @WoolfsonLab. @BristolBiochem @BristolChem @BrisBioDesign
nature.com/articles/s41589-0…
Very interesting work showing that local translation on axonal ER tubules is mediated by RRBP1 #JournalClub
doi.org/10.1016/j.devcel.202…
Carter Lab retweeted
Excited to share our latest study! We discovered that maintaining mammalian oocytes involves extraordinary protein longevity. These proteins support key functions like proteostasis, the cytoskeleton, and mitochondria. Our findings offer new insights into reproductive aging.
Women are born with all their oocytes, which need to stay viable for decades to ensure fertility. How are they maintained for that long?
Our latest research in @NatureCellBio reveals that oocyte maintenance involves exceptional protein longevity. nature.com/articles/s41556-0… (1/9)
In yesterday's #journalclub, we had a look at the interesting mechanism by which the UNC-104 motor (Kinesin-3 KIF1A homologue in C. elegans) is stabilised on Rab-3-containing synaptic vesicles - by Bhan and colleagues
biorxiv.org/content/10.1101/…
Today in #Journalclub we looked at how Alphafold2 models can guide prospective ligand discovery. A nice study combing in-silico docking and cryo-EM out now in @ScienceMagazine
science.org/doi/10.1126/scie…
Great work from the McKenney lab reconstituting the KASH protein Nesprin-2 bridging actin to kinesin/MTs #journalclub biorxiv.org/content/10.1101/…
Today in #journalclub we delved into the structure of the Flotillin complex. Fascinating insights into how this cage complex could induce membrane curvature and provide a sealed diffusion barrier, connecting membrane systems. biorxiv.org/content/10.1101/…