The Pralle Lab at UB - fundamental biophysics of the brain and body, motivated by medical applications
Buffalo, NY
Joined June 2018
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PralleLab retweeted
🚨 Second preprint of the week!
We uncover the multiscale dynamics of active viscoelastic buckling in epithelia.
We harness these mechanical instabilities for synthetic morphogenesis.
Led by @onenimesa🙌. Theory by Marino Arroyo and team.
biorxiv.org/content/10.1101/…
PralleLab retweeted
NIH grant awards plummeted $2.3 billion under President Trump statnews.com/2025/04/24/trum…
PralleLab retweeted
A new optical biosensor can probe the activities of native GPCRs in live cells, and, unlike typical sensors doesn’t interfere with downstream signaling and can be deployed in many cell types with only a single construct. scim.ag/4cno5L1 @scisignal
PralleLab retweeted
Sound-sheet microscopy is born! Congratulations to Baptiste Heiles, lab members and collaborators at the Shapiro Lab (Caltech) and Gazzola Lab (NIN/KNAW) for this scientific achievement 🚀.
A new method reported in Science allows the generation of 3D ultrasound images of gene expression and 2D ultrasound images of capillary vessels. The approach enables fast, deep, and volumetric imaging of living opaque organs labeled with echogenic reporters.
Learn more in this week's issue: scim.ag/3R0HCXW
ALT A cross-propagating ultrasound wave exposes a thin tissue section that contains blood vessels feeding a tumor. The wave interacts with sound-scattering probes (displayed in orange gold) that are genetically expressed in cancer cells or are injected in the bloodstream to reveal capillary vessels. White contour lines indicate previously scanned tissue sections and the total volume explored by this sound-sheet microscopy technique.
PralleLab retweeted
In our new preprint, we study the physical aging of biochemically active condensates formed by an engineered Tau protein into disease-linked amyloid fibrils — and investigate whether small molecules can counteract this transition. @BanerjeeLab_UB
biorxiv.org/content/10.1101/…
🧵1/3
PralleLab retweeted
Excited to share our work out in @CurrentBiology ! We find that SKAP's binding to microtubules *reduces* friction at the kinetochore-microtubule interface and increases attachment stability under force. Congrats to postdoc Miquel @RosasSalvans and all authors! With @Caleb_J_Rux and Moumita Das.
sciencedirect.com/science/ar…
PralleLab retweeted
I found out this morning that my @NIH @NICHD_NIH F31 fellowship to study the biomechanics of uterine fibroids was CANCELLED. – at Manhattan, NY
PralleLab retweeted
We are thrilled to share this work linking specific human brain cell types to psychiatric and neurological disorders, out now in @NatureNeuro rdcu.be/d6Tcy See below for an overview and thanks to the amazing Tayden Li, @willgiardino, @deissero, and so many others!
PralleLab retweeted
Beyond excited to share my big @StJude news! We’re going to build an amazing hub for imaging technology development and deployment - driven by St Jude’s mission to transform the way the world understands and treats pediatric catastrophic diseases. Imaging innovators come join us!
St. Jude welcomes @HillmanLab as the founding chair of the new Department of Imaging Sciences. Her team will develop innovative tools to accelerate discovery and improve patient care. ow.ly/GZQG50UL653
PralleLab retweeted
Excited to share our new preprint! Exceptional work by postdoc @MikeLange identifies the first #LipidDroplet lipid quality control pathway! Droplet-localized FSP1 safeguards stored neutral lipids, blocking their peroxidation & #ferroptosis induction.🤩biorxiv.org/content/10.1101/…
Interesting work by @JorgGrandl shows how Piezo1 shape affects nearby channels directly.
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PralleLab retweeted
Just posted the most biologically important photopharmacology story we've had in the last few years.
Ditched the photoswitch design principles we used for the last 10 years, & started all over again.
And now it will work in vivo.
doi.org/10.1101/2024.07.12.6…
🧵1/n🧵
PralleLab retweeted
Today in @ScienceMagazine we report how lipids specialize for life under the crushing pressures of the deep sea and what this means more broadly for the composition of cell membranes (1/n) science.org/doi/10.1126/scie…
Impressively strong magnetic effect on fluorescence of engineered protein
Opens up new avenues for magnetogentics
Meet MagLOV: an engineered protein that responds STRONGLY to magnetic fields.
This is a fluorescence timelapse of MagLOV in E. coli. We're waving a (small) magnet under the plate.
Can you tell where the magnet is?
Want some? It's on Addgene now! addgene.org/219957/
PralleLab retweeted
We used light to herd cell growth with @toettch lab! Optogenetics is pretty cool. Super fun collab. and exquisite data from @KevinSuhhh* and @RichardHT_*. Video: blue light pattern--> sheet of living tissue rearranges into creepy eye. See @toettch for🧵. biorxiv.org/content/10.1101/…
PralleLab retweeted
How do bacteria grow and move in large groups where cells appear adhered to each other but can move freely? Using capillary forces from thin layers of water! Check out our new preprint with Matt Black, Chenyi Fei, @RicardAlert and Ned Wingreen: biorxiv.org/content/10.1101/…
PralleLab retweeted
Some of us were asked by @CellCellPress about the future of mechanobiology. In all likelihood, 20 years from now we'll see we were all wrong. Any thoughts? What did we miss?🤔🔮👇authors.elsevier.com/a/1j8Ml…
Beautiful, powerful methods to quantified lipid flow in cells, demonstrating the importance of non-vesicular lipid transport. Congratulations to the team.
Here’s the big one: In collaboration with @Honigmann_Lab, @LabShevchenko, Björn Drobot and Martin Hof we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
biorxiv.org/content/10.1101/…
