@DumontLab
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Mechanics of cell division @UCSF
San Francisco, CA
Joined May 2015
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Excited to share our work out in @CurrentBiology today! We find that NuMA acts as a spindle "glue" - independent of its partner dynein. Congrats to student Nathan Cho who led the work, and thanks to Merve, Aryan and @Yildiz_Lab for in vitro help. cell.com/current-biology/ful…
Excited to share NuMA preprint #2/2! We report structural and functional insights into how NuMA activates and regulates dynein at cell division. Congrats to Merve Aslan @Yildiz_Lab, @AmicoEnnio @Carter_Lab and Nathan Cho from our lab. And others inc. Maddie Blaauw from our lab.
biorxiv.org/content/10.1101/…
Excited to share NuMA preprint #1/2! We find that NuMA mechanically reinforces the spindle independently of its partner dynein. Congrats to student Nathan Cho who led the work, with Merve Aslan and @Yildiz_Lab. biorxiv.org/content/10.1101/…
Congrats to Alexandra Long @alexandraflong, the second student from our lab to start their own lab! Her lab is in Univ. Kentucky's Biology Dept, studying the evolutionary cell biology & biophysics of cellular organization. Check it out! alonglab.org
Excited to share our work out in @CurrentBiology ! We find that SKAP's binding to microtubules *reduces* friction at the kinetochore-microtubule interface and increases attachment stability under force. Congrats to postdoc Miquel @RosasSalvans and all authors! With @Caleb_J_Rux and Moumita Das.
sciencedirect.com/science/ar…
Nominate a colleague or yourself for the Motility and Cytoskeleton Early Career Award at the 2025 Biophysical Society Meeting! To do so fill out this form and email Radhika Subramanian and I your CVs by Dec 1 2024: docs.google.com/forms/d/e/1F…
Congrats to Christina Hueschen @clhueschen, the first student from our lab to start their own lab! Her lab is in UCSD's Cell & Dev Bio Dept, studying the physical biology of parasites. Can't wait to see what science they do. Check it out! hueschenlab.biosci.ucsd.edu/
Christina was a postdoc with Alex Dunn @Dunn_Lab. And wrote a book with Rob Phillips, The Restless Cell: Continuum Theories of Living Matter. Wow ...
Excited to share a preprint! We find that SKAP's binding to microtubules *reduces* friction at the kinetochore-microtubule interface and increases attachment stability under force. Congrats to postdoc Miquel @RosasSalvans and all authors! With @Caleb_J_Rux and Moumita Das.
biorxiv.org/content/10.1101/…
With this work we are sad to say goodbye to postdoc Miquel @RosasSalvans who is returning to Barcelona. We will miss Miquel's intellect, generous spirit, and all the fun times doing science together. Best of luck!
Nominate a colleague or yourself to speak at the Motility & Cytoskeleton Subgroup at the 2025 Biophysical Society Meeting! Radhika Subramanian and I are organizing the subgroup and looking for nominations by July 8th: forms.gle/i3AMosmEugx2cnfn8.
Excited to share our work @JCellBiol! We find that torques within and outside the spindle oppose each other to limit spindle twist during anaphase. Congrats to @LilaNeahring who led the work! Thanks to Nathan Cho, @Caleb_J_Rux, @Yildiz_Lab, Upadhyayula and Subramanian Labs. rupress.org/jcb/article/223/…
Excited to share our work @JCellBiol! We find that chromosome size-dependent spindle forces impair mammalian mitotic error correction of long chromosomes. Congrats to graduate student
@megan_chong who led this work! With Miquel
@RosasSalvans @VannaTran5
rupress.org/jcb/article/223/…
Excited to share our work out in @PLOSONE with @goga_lab showing that expressing an oncogene protects spindle poles from fracturing in mechanically confined environments. Congrats to first authors @RenaldoSutanto and @LilaNeahring and all authors! journals.plos.org/plosone/ar…
Congratulations to graduate student @megan_chong from our lab who received a UCSF Dean’s Award for Excellence in Mentoring! Megan is an inspiring mentor to many in our lab and out. And congrats to all other awardees! @UCSFGradDiv
Excited to share a preprint! We find that torques within and outside the human spindle oppose each other to limit spindle twist during chromosome segregation. Congrats to @LilaNeahring who led the work! biorxiv.org/content/10.1101/…
Thanks to Nathan Cho, @Caleb_J_Rux and collaborators @Yildiz_Lab, Upadhyayula and Subramanian Labs!
Lab dinner with past and present lab members at #CellBio2023 😊
Our lab is exicted to be at @ASCBiology
#cellbio2023 in Boston. Come check out what we've been up to! @c3STC
