@PralleLab

The Pralle Lab at UB - fundamental biophysics of the brain and body, motivated by medical applications

 Buffalo, NY
acsu.buffalo.edu/~apralle/
Joined June 2018
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  • Following484
  • Followers206
4Media
🚨 Second preprint of the week! We uncover the multiscale dynamics of active viscoelastic buckling in epithelia. We harness these mechanical instabilities for synthetic morphogenesis. Led by @onenimesa🙌. Theory by Marino Arroyo and team. biorxiv.org/content/10.1101/…
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NIH grant awards plummeted $2.3 billion under President Trump statnews.com/2025/04/24/trum…

NIH grants plummeted $2.3 billion in Trump’s first months, as federal-academia partnership crumbles

The NIH has scaled back its awards of new grants by at least $2.3 billion since the beginning of the year, a STAT analysis shows.

statnews.com
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A new optical biosensor can probe the activities of native GPCRs in live cells, and, unlike typical sensors doesn’t interfere with downstream signaling and can be deployed in many cell types with only a single construct. scim.ag/4cno5L1 @scisignal
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Sound-sheet microscopy is born! Congratulations to Baptiste Heiles, lab members and collaborators at the Shapiro Lab (Caltech) and Gazzola Lab (NIN/KNAW) for this scientific achievement 🚀.
Science Magazine
@ScienceMagazine3 Apr 2025
A new method reported in Science allows the generation of 3D ultrasound images of gene expression and 2D ultrasound images of capillary vessels. The approach enables fast, deep, and volumetric imaging of living opaque organs labeled with echogenic reporters. Learn more in this week's issue: scim.ag/3R0HCXW
A cross-propagating ultrasound wave exposes a thin tissue section that contains blood vessels feeding a tumor. The wave interacts with sound-scattering probes (displayed in orange gold) that are genetically expressed in cancer cells or are injected in the bloodstream to reveal capillary vessels. White contour lines indicate previously scanned tissue sections and the total volume explored by this sound-sheet microscopy technique.

ALT A cross-propagating ultrasound wave exposes a thin tissue section that contains blood vessels feeding a tumor. The wave interacts with sound-scattering probes (displayed in orange gold) that are genetically expressed in cancer cells or are injected in the bloodstream to reveal capillary vessels. White contour lines indicate previously scanned tissue sections and the total volume explored by this sound-sheet microscopy technique.

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In our new preprint, we study the physical aging of biochemically active condensates formed by an engineered Tau protein into disease-linked amyloid fibrils — and investigate whether small molecules can counteract this transition. @BanerjeeLab_UB biorxiv.org/content/10.1101/… 🧵1/3
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Excited to share our work out in @CurrentBiology ! We find that SKAP's binding to microtubules *reduces* friction at the kinetochore-microtubule interface and increases attachment stability under force. Congrats to postdoc Miquel @RosasSalvans and all authors! With @Caleb_J_Rux and Moumita Das. sciencedirect.com/science/ar…
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I found out this morning that my @NIH @NICHD_NIH F31 fellowship to study the biomechanics of uterine fibroids was CANCELLED. – at Manhattan, NY
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We are thrilled to share this work linking specific human brain cell types to psychiatric and neurological disorders, out now in @NatureNeuro rdcu.be/d6Tcy See below for an overview and thanks to the amazing Tayden Li, @willgiardino, @deissero, and so many others!
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Beyond excited to share my big @StJude news! We’re going to build an amazing hub for imaging technology development and deployment - driven by St Jude’s mission to transform the way the world understands and treats pediatric catastrophic diseases. Imaging innovators come join us!
St. Jude Research
@StJudeResearch22 Jan 2025
St. Jude welcomes @HillmanLab as the founding chair of the new Department of Imaging Sciences. Her team will develop innovative tools to accelerate discovery and improve patient care. ow.ly/GZQG50UL653
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Excited to share our new preprint! Exceptional work by postdoc @MikeLange identifies the first #LipidDroplet lipid quality control pathway! Droplet-localized FSP1 safeguards stored neutral lipids, blocking their peroxidation & #ferroptosis induction.🤩biorxiv.org/content/10.1101/…

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis

Lipid droplets (LDs) are organelles that store and supply lipids based on cellular needs. While mechanisms preventing oxidative damage to membrane phospholipids are established, the vulnerability of...

biorxiv.org
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SNAP-tag2: faster and brighter protein labeling biorxiv.org/content/10.1101/…
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Just posted the most biologically important photopharmacology story we've had in the last few years. Ditched the photoswitch design principles we used for the last 10 years, & started all over again. And now it will work in vivo. doi.org/10.1101/2024.07.12.6… 🧵1/n🧵
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PralleLab retweeted
Itay Budin@ibudin27 Jun 2024
Today in @ScienceMagazine we report how lipids specialize for life under the crushing pressures of the deep sea and what this means more broadly for the composition of cell membranes (1/n) science.org/doi/10.1126/scie…

Homeocurvature adaptation of phospholipids to pressure in deep-sea invertebrates

Hydrostatic pressure increases with depth in the ocean, but little is known about the molecular bases of biological pressure tolerance. We describe a mode of pressure adaptation in comb jellies...

science.org
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We used light to herd cell growth with @toettch lab! Optogenetics is pretty cool. Super fun collab. and exquisite data from @KevinSuhhh* and @RichardHT_*. Video: blue light pattern--> sheet of living tissue rearranges into creepy eye. See @toettch for🧵. biorxiv.org/content/10.1101/…
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How do bacteria grow and move in large groups where cells appear adhered to each other but can move freely? Using capillary forces from thin layers of water! Check out our new preprint with Matt Black, Chenyi Fei, @RicardAlert and Ned Wingreen: biorxiv.org/content/10.1101/…
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Some of us were asked by @CellCellPress about the future of mechanobiology. In all likelihood, 20 years from now we'll see we were all wrong. Any thoughts? What did we miss?🤔🔮👇authors.elsevier.com/a/1j8Ml…
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Hello, my absolutely lovely membrane peeps! Would you maybe, pretty-please, let me proudly steer you to a MINI-REVIEW I recently wrote? It’s on asymmetric membranes in general, and differential stress in particular—subjects that I am massively interested in right now! 1/26
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Can you use simple diagnostic ultrasound to flip a "diffusion switch" in a hydrogel and deliver drugs? Yes, with Acoustic Percolation Switches! Congrats to Paulene Abundo, Anna Tifrea, @MarjorieBuss and colleagues on this advance. biorxiv.org/content/10.1101/… #gasvesicles
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Just out!🥳 Measuring membrane fluidity with FLIM🔬 pubs.acs.org/doi/10.1021/acs… Lifetimes of NR12S, NR12A and Flipper show varying sensitivities to different lipid environments and exhibit longer lifetimes at longer emission wavelengths irrespective of membrane complexity.

Quantifying Fluorescence Lifetime Responsiveness of Environment-Sensitive Probes for Membrane...

Abstract. The structural diversity of different lipid species within the membrane defines its biophysical properties such as membrane fluidity, phase trans

pubs.acs.org
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Biomolecular #condensates interact with membranes in intricate ways. Here is a review in @AnnualReviews coauthored by @agumangia, where we discuss lipid-anchored and non-anchored condensates. @MpiciPotsdam @PotsdamScience bit.ly/4bRb2Rn
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