@OlzmannLab

Professor of Molecular Therapeutics and Metabolic Biology at UC Berkeley; Departments of Molecular & Cell Biology and Nutritional Sciences & Toxicology

 Berkeley, California. USA.
olzmannlab.com/
Joined August 2018
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  • Followers11.1K
437Media
1/ Thrilled to share our new paper in @Nature: “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” From our lab together with @apsarruda, led by co–first authors @alymathiowetz and @EmilyMeymand. 🥳 nature.com/articles/s41586-0…

CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly

Nature - CRISPR–Cas9 screening identifies CLCC1 as a factor that increases neutral lipid flux to prevent hepatic steatosis and promotes nuclear pore complex assembly by promoting membrane...

nature.com
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Albert Pol Lab@AlbertPol10
Sep 24
Curious how lipid droplets support innate immunity in our cells? Check out our lipidomics by Bosch et al @CellReports! Critical role of LD phospholipids and lipases in supplying defensive w6 arachidonic acid for inflammation and bacterial phagocytosis. cell.com/cell-reports/fullte…
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Thrilled to share our new paper in Science! science.org/doi/10.1126/scie…

Mammals produce cyclo-octasulfur to suppress lipid peroxidation and ferroptosis

Elemental sulfur is an evolutionarily ancient metabolite, yet its generation, storage, and function in animals have remained unclear. We show that mammals harbor elemental sulfur in the form of its...

science.org
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🔬Event report🔬 UC Berkeleyからお越しのJames Olzmann先生をお迎えして座談会を行いました🥳 先生のこれまでのキャリアパスについて伺い、新しい分野に挑戦する際のマインドセットなど、多くの学びを得ることができました。 @OlzmannLab Great respect for your journey. Thank you very much!!
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Excited to see this online and to have contributed in a small way! Huge congratulations to @Sulfur_Vladi, Takaaki Akaike & team. Elemental sulfur (S8) accumulates in lipid droplets, & protects against lipid peroxidation and ferroptosis! 🔥 science.org/doi/10.1126/scie…

Mammals produce cyclo-octasulfur to suppress lipid peroxidation and ferroptosis

Elemental sulfur is an evolutionarily ancient metabolite, yet its generation, storage, and function in animals have remained unclear. We show that mammals harbor elemental sulfur in the form of its...

science.org
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サバティカルで東北大学に滞在中のJames Olzmann教授@OlzmannLab のセミナーが10月8日に開催されます。興味のある方は是非ご参加ください。#Ferroptosis #lipidbiology #lipiddroplet
東北大学大学院医学系研究科@tohoku_univ_med
Sep 18
【イベント】 東北医学会特別講演会 開催のお知らせ（10/8開催） med.tohoku.ac.jp/6353/ #東北大学医学部 #イベント #東北医学会
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【イベント】 東北医学会特別講演会 開催のお知らせ（10/8開催） med.tohoku.ac.jp/6353/ #東北大学医学部 #イベント #東北医学会
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James Olzmann retweeted
Giovanni D'Angelo
@Gio_Dangel0
Sep 23
#lipidtime: It's a lipid universe. Today in Nature we publish the Lipid Brain Atlas, the first map of membrane lipid composition across the entire mouse brain, a layer of organisation that cell-type and transcript maps had left out. #lipidomics #neuroscience #BrainAtlas
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UC Berkeley
@UCBerkeley
Sep 22
Once again, U.S. News & World Report (@usnews) has named UC Berkeley the #1 public university (tied). Berkeley has topped the rankings for much of the 21st century. 🥇 bit.ly/4xFfAUF
A multicolored gradient over an image of a clock tower. Text over the image reads "UC Berkeley", "#1 public university", "According to U.S. News & World Report 2027 Best Colleges"]

ALT A multicolored gradient over an image of a clock tower. Text over the image reads "UC Berkeley", "#1 public university", "According to U.S. News & World Report 2027 Best Colleges"]

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Save the date! 🔥 The 2027 FASEB Science Research Conference on Ferroptosis: From Mechanism to Medicine is coming to Denver, July 12–15! We are excited to bring the ferroptosis community together again. Experts and newcomers welcome! Please help spread the word! More info soon!
🤖 Made with AI
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Roberto Zoncu@RobertoZoncu
Sep 18
Fantastic visit and seminar by Heather @ChristofkLab to our #MolecularTherapeutics series @berkeleyMCB. Heather’s work is truly unique in connecting fundamental metabolic insights to translation & therapy!
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ZhengLab@LabZheng
Sep 16
Two decades after revealing the mechanism of action of auxin, we have now uncovered the molecular mystery of another plant hormone: salicylic acid (SA), the precursor of aspirin that most of us have taken at some point in our lives. We were surprised again rdcu.be/EbdVwEStSHha
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James Olzmann retweeted
Yasunori Saheki@ysaheki
Sep 16
Our new paper revealing the link between cholesterol and the clearance and recycling of damaged mitochondria is now published in @NatureComms! Congrats to @YHaoning & Koji @NTUsg who led the study, and thanks to Aik Yong & @Isaspore @NUSMedicine for CLEM! nature.com/articles/s41467-0…
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Kivanc Birsoy@KivancBirsoy
Sep 15
Why is glutathione, rather than cysteine, the major cellular thiol? Our new work by @ToshiNakamura51 suggests unlike other amino acids, excess cysteine is intrinsically toxic to mammalian cells via mitochondrial iron accumulation. @RockefellerUniv nature.com/articles/s42255-0…

Cysteine excess triggers a mitochondrial iron-dependent cell death

Nature Metabolism - Using a genome-wide CRISPR screen, the authors demonstrate that excess cysteine drives mitochondrial iron accumulation and iron–sulfur cluster failure, triggering a...

nature.com
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Cell@CellCellPress
Sep 3
In the latest issue! Metabolite buffering of labile iron governs ferroptosis dlvr.it/TVK0lZ

Metabolite buffering of labile iron governs ferroptosis

Iron abundance alone does not determine ferroptosis sensitivity. In this issue of Cell, Sharma and colleagues identify polyamines as endogenous metabolic buffers that reduce the chemical accessibil...

cell.com
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Excited to see our Preview led by Amalia Megarioti online in Cell, highlighting new work showing that polyamines act as endogenous buffers of labile iron to suppress ferroptosis. Congrats to Pushkal Sharma, Whitney Henry, Ankur Jain and team!👏 cell.com/cell/fulltext/S0092…

Metabolite buffering of labile iron governs ferroptosis

Iron abundance alone does not determine ferroptosis sensitivity. In this issue of Cell, Sharma and colleagues identify polyamines as endogenous metabolic buffers that reduce the chemical accessibil...

cell.com
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UC BerkeleyのJames Olzmann教授 @OlzmannLab がサバティカルを利用して４ヶ月間 東北大学医学部に滞在されます。 Olzmann教授はフェロトーシスや脂質バイオロジーの専門家で、この滞在を利用して日本国内の研究者とも共同研究やdisucssionをさらに進められる予定です
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Amy Strom@DNAmyStrom
Aug 28
My group in Discovery Oncology at @genentech uses machine learning to design new ways to target previously "undruggable" cancer-causing proteins. Go #InTheLab with me to learn more about connecting Oncology and AI-- linkedin.com/posts/genentech…
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Dan Nomura
@DanNomura
Aug 18
Excited to share our latest preprint led by Taylor Nuttall, in collaboration with @GileadSciences ! We identify a stereoselective covalent small molecule targeting the “undruggable” ovarian cancer transcription factor PAX8. KL6-159A covalently engages PAX8 C57, destabilizes PAX8, and suppresses its oncogenic transcriptional program, with FOXM1 emerging as the most strongly suppressed regulatory network. Another example of how reactive amino acid hotspots can provide unexpected footholds for directly drugging historically intractable transcription factors. biorxiv.org/content/10.64898… #Chemoproteomics #ChemicalBiology #DrugDiscovery #PAX8 #OvarianCancer biorxiv.org/content/10.64898…

Stereoselective Covalent Inhibitor of the Ovarian Cancer-Driving Transcription Factor PAX8

Transcription factors remain among the most challenging therapeutic targets in part because they lack well-defined ligandable binding pockets. We recently showed that aberrantly reactive cysteines in...

biorxiv.org
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📢 We’re hiring! The Stanford Chemistry Department is now actively conducting faculty searches (open area) - term to start on 9/1/2027: - Assistant Professor in Chemistry - Senior Faculty Position in Chemistry (Associate Professor or Professor) Learn more: chemistry.stanford.edu/news/…
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UC Berkeley MCB@berkeleyMCB
Aug 14
MCB is hiring Assistant Professors across 3 divisions!: 🧪 BBS: aprecruit.berkeley.edu/JPF05… 🧬GGED: aprecruit.berkeley.edu/JPF05… 🦠IMM: aprecruit.berkeley.edu/JPF05… 🗓️ Application Deadline: October 19, 2026 🔗 Click the links or scan the QR codes to learn more and apply
MCB is hiring 3 Assistant Professor positions across 3 divisions: Biochemistry, Biophysics and Structural Biology (BBS); Genetics, Genomics, Evolution, and Development (GGED); and Immunology and Molecular Medicine (IMM) BBS application link: https://aprecruit.berkeley.edu/JPF05483 GGED application link: https://aprecruit.berkeley.edu/JPF05481 IMM application link: https://aprecruit.berkeley.edu/JPF05486

ALT MCB is hiring 3 Assistant Professor positions across 3 divisions: Biochemistry, Biophysics and Structural Biology (BBS); Genetics, Genomics, Evolution, and Development (GGED); and Immunology and Molecular Medicine (IMM) BBS application link: https://aprecruit.berkeley.edu/JPF05483 GGED application link: https://aprecruit.berkeley.edu/JPF05481 IMM application link: https://aprecruit.berkeley.edu/JPF05486

Assistant Professor of Immunology and Molecular Medicine. IMM application link: https://aprecruit.berkeley.edu/JPF05486

ALT Assistant Professor of Immunology and Molecular Medicine. IMM application link: https://aprecruit.berkeley.edu/JPF05486

Assistant Professor of Biochemistry, Biophysics and Structural Biology (BBS). BBS application link: https://aprecruit.berkeley.edu/JPF05483

ALT Assistant Professor of Biochemistry, Biophysics and Structural Biology (BBS). BBS application link: https://aprecruit.berkeley.edu/JPF05483

Assistant Professor of Genetics, Genomics, Evolution, and Development (GGED). GGED application link: https://aprecruit.berkeley.edu/JPF05481

ALT Assistant Professor of Genetics, Genomics, Evolution, and Development (GGED). GGED application link: https://aprecruit.berkeley.edu/JPF05481

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