Doing epithelial mechanics! Convenor @EpiMechFC Postdoc @NerurkarLab @ColumbiaBME Past: PhD @XavierTrepat lab @IBECBarcelona; ME @IiscMechanical
New York City
Joined April 2019
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How does a relatively simple tube become a complex brain? 🧠
One of the most dramatic transformations in development!
We built a framework to map exactly what changes. 🧵
New preprint from my postdoc at @ColumbiaBME :
doi.org/10.64898/2026.05.18.…
Nimesh Chahare retweeted
How does a relatively simple tube become a complex brain? 🧠
One of the most dramatic transformations in development!
We built a framework to map exactly what changes. 🧵
New preprint from my postdoc at @ColumbiaBME :
doi.org/10.64898/2026.05.18.…
What drives the thickening?
We mapped cell division across the whole neural tube
The DV mitotic gradient is conserved
This is far more complex than a passive shell
Floor/roof plate signaling likely encodes the pre-pattern, while mechanics drives the global shape change
Thanks for following along! 🙏
This work wouldn't exist without the wonderful Nerurkar Lab
& the humble chicken embryo system.
Special thanks to Nandan for the mentorship & support. Code is public: github.com/nchahare/spatchco…
Have a curved tubular tissue? Spatchcock it.
Nimesh Chahare retweeted
Our latest work on shape-programmable tissues is out in @ScienceMagazine.
science.org/doi/10.1126/scie…
Collab with Marino Arroyo’s lab, led by @pauguillamat at @IBECBarcelona
Nimesh Chahare retweeted
Meet the Epithelial Mechanics Fan Club @EpiMechFC
@onenimesa and @JuliaEckert10 introduce us to the Epithelial Mechanics Club.
Learn how you can get involved with this community: focalplane.biologists.com/20…
Nimesh Chahare retweeted
Check out the preprint of my main work in the lab of @XavierTrepat @IBECBarcelona. Many thanks to all the people involved!
New preprint! 🚨 We uncover a slow adaptation to stretch that links star-bundling of keratin filaments with nuclear escape from its keratin cage. Led by @tom_golde 🙌 @IBECBarcelona biorxiv.org/content/10.1101/…
Nimesh Chahare retweeted
Over the past 2 years, we have enjoyed reading the wonderful threads of our delegates around the world. Thank you!
What have we missed? What is your favourite topic? Your recent paper?
Click the link below to sign up and share your passion with us 👇
buff.ly/hdqN1Np
Nimesh Chahare retweeted
Have you ever thought about inflating tissues?
Or maybe quickly deflating those inflated tissues?
New #EpithelialMechanics pre-print: doi.org/10.1101/2025.06.30.6…
🧵with pressure control, multiscale buckling, patterned wrinkling
Nimesh Chahare retweeted
A thread of our new preprint 🧵👇 🤩
Have you ever thought about inflating tissues?
Or maybe quickly deflating those inflated tissues?
New #EpithelialMechanics pre-print: doi.org/10.1101/2025.06.30.6…
🧵with pressure control, multiscale buckling, patterned wrinkling
Thank you Xavi!
Click on this to see epithelial pressure control, multiscale buckling, controlled wrinkling
xitter.cf/onenimesa/status/19407…
🚨 Second preprint of the week!
We uncover the multiscale dynamics of active viscoelastic buckling in epithelia.
We harness these mechanical instabilities for synthetic morphogenesis.
Led by @onenimesa🙌. Theory by Marino Arroyo and team.
biorxiv.org/content/10.1101/…
Nimesh Chahare retweeted
to buckle or not to buckle that is the question🤔
So great to see this work out!! Big congrats to @onenimesa and the team!!👏
🚨 Second preprint of the week!
We uncover the multiscale dynamics of active viscoelastic buckling in epithelia.
We harness these mechanical instabilities for synthetic morphogenesis.
Led by @onenimesa🙌. Theory by Marino Arroyo and team.
biorxiv.org/content/10.1101/…
Nimesh Chahare retweeted
🚨 Second preprint of the week!
We uncover the multiscale dynamics of active viscoelastic buckling in epithelia.
We harness these mechanical instabilities for synthetic morphogenesis.
Led by @onenimesa🙌. Theory by Marino Arroyo and team.
biorxiv.org/content/10.1101/…
Have you ever thought about inflating tissues?
Or maybe quickly deflating those inflated tissues?
New #EpithelialMechanics pre-print: doi.org/10.1101/2025.06.30.6…
🧵with pressure control, multiscale buckling, patterned wrinkling
Finally, we could use control of shape to rationally direct buckling into predictable wrinkle patterns.
9/10
I want to acknowledge that it truly takes a village to conduct science and produce preprints.
A huge thank you to the my labs!
specifically the Moli team:
@tom_golde Thomas Wilson, @oozguc
Marino Arroyo & @XavierTrepat