@WellcomeTrust and @BBSRC funded projects studying the structure and function of the #Cdiff S-layer with @GillDouce1, @PerBullough, @PSSalgado and @RobFagan
Joined January 2018
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Bug Slayers is a collaborative effort involving 4 research groups, 4 postdoctoral scientists and 2 PhD students @SheffieldUni, @UofGlasgow & @UniofNewcastle In this thread I’ll introduce our team
Fantastic to see another beautiful S-layer structure! Congratulations to the @RemautHan group
nature.com/articles/s41467-0…
Bug Slayers retweeted
And so we finish #clostpath2023, and look ahead to #clostpath2025 in #Paris! Local organisers @JohannPeltier @MorvanClaire2 and Thomas Candela. Good luck!
Bug Slayers retweeted
Did I mention that besides great science #clostpath2023 also features stunning autumn weather? @ramelnyk held word!
Bug Slayers retweeted
Really enjoyed sharing our work in Clostridium sporogenes at #Clostpath2023 this morning! Thanks to @dw_scientific for supporting my attendance at the conference and of course to the lab @PerBullough @RobFagan
@BeckyMenday @BuddleJess
New paper from the @BugS_layers team! We show that the S-layer is necessary for virulence in mice and that the in vivo environment exerts a strong selective pressure that favours restoration of the S-layer in an S-layer-null mutant
journals.plos.org/plospathog…
We also determined another cool #BugSlayer structure, a tour de force from @barwinskasendra. Confirms our model for how SlpA packs into a lattice, with minor adjustments of charged interfaces.
Required reading for all interested in S-layers from @TBharat_lab
biorxiv.org/content/10.1101/…
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Surface (S-) layer proteins are a bridge that connects multispecies microorganisms in anammox biofilms microbiologycommunity.nature… #behindthepaper
Always exciting to see a new S-layer structure! Beautiful work here from @DaumLaboratory
What do archaeal cell surfaces look like?
Check out our latest preprint on the structure of the S-layer of the archaeon Sulfolobus acidocaldarius! biorxiv.org/content/10.1101/…!
Next Monday @pssalgado will share our work on #Cdiff S-layer at the Cell Envelopes Symposium - register to join and please spread the word!
eventbrite.co.uk/e/bacterial…
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Solving the C. difficile’s armour - while developing my own
@PaolaLanzoni tells her story #BehindThePaper
@BugS_layers @barwinskasendra @JSamWilson @OishikBanerji @PerBullough @RobFagan @pssalgado @GillDouce1 @FairweatherNeil @Joekaryotic @filipacostavaz
go.nature.com/3sZWj27
Congratulations Shauna! The newest @BugS_layers PhD
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Our work revealing the structure and organisation of #BugSlayer in #Cdiff is finally out in @NatComms! Huge team effort from joint 1st authors @PaolaLanzoni, @barwinskasendra, @JSamWilson, @OishikBanerji! #SlayerStructure nature.com/articles/s41467-0… 1/n
8. Removing the most exposed SLPL domain (D2), doesn’t change the overall SlpA structure and a functional S-layer is assembled. However, #Cdiff then becomes susceptible to lysozyme, even though the pores are still very narrow (16A). #SlayerStructure #BugSlayers 10/n
Many new questions to answer: how do things go in/out of the #Cdiff cells? How can we disrupt this armour? How does the #SlayerStructure link to function and infection? Lots to keep us busy, but for now, a huge thank you to the whole @BugS_layers team! 11/11
Bug Slayers retweeted
The spectacular structure of the protective armour of superbug #Cdiff revealed for the 1st time by @pssalgado (@MolMecNCL) @BugS_layers in @NatureComms shows the close-knit outer layer, like chain mail, protects the bug & provides a new target for drugs. ncl.ac.uk/press/articles/lat…
