Assoc. prof. @LUMC_Leiden/CMAT. Cdiff, DNA replication, AMR, microbiome, anaerobes. Clostpath SC. Education officer ESGCD. Also: @smitslab.bsky.social
Leiden, Nederland
Joined August 2015
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[🔔] Publication alert! The CloDiCo trial is now published in @NatureComms @NaturePortfolio (Editor's choice!). This is the work of an amazing team, and led by PhD student Annefleur Hensen. Check out this thread [👇] for a summary of the study.
nature.com/articles/s41467-0…
1/10
The effects of novel oral preclinical PolC inhibitor antibiotic candidates on the gut microbiome in a murine thigh infection model | Microbiology Spectrum journals.asm.org/doi/10.1128…
A call for sharing phenotypic antimicrobial susceptibility data alongside bacterial genome sequence data in public archives nature.com/articles/s44259-0…
Genomic and socioeconomic drivers of antimicrobial resistance forecast to 2050: Cell Genomics cell.com/cell-genomics/fullt…
Phases of Clostridioides difficile Infection (CDI) in the United States: The History and Epidemiology of CDI From 1935 to Present academic.oup.com/cid/article… "... prepare for a different kind of CDI: community-based and insidious rather than hospital-predominant and explosive."
DNA polymerase I and DnaE mediate RNA-templated DNA synthesis over embedded ribonucleotides academic.oup.com/nar/article…
The Master Regulator Spo0A Integrates DNA Sequence and Shape to Regulate the Sporulation Kinase Gene kinA in Bacillus subtilis - onlinelibrary.wiley.com/doi/…
An endolysin-expressing probiotic attenuates Clostridioides difficile infection in germ-free and dysbiotic microbiota-associated mice biorxiv.org/content/10.64898…
Wiep Klaas Smits retweeted
When Pseudomonas is attacked, it strikes back!
Outer membrane damage triggers a tit-for-tat T6SS retaliation via TagQ/TagR protein complex assembly, activating the PpkA kinase.
Congrats to Maxim & team for uncovering this fascinating mechanism!
nature.com/articles/s41467-0…
Wiep Klaas Smits retweeted
The Peggy Lillis Foundation (cdiff.org/) invites clinicians, researchers, scientists, pharmacists, and industry professionals to submit abstracts for the November 19-20 2026 Clostridioides difficileScientific Symposium. The submission deadline is October 23, 2026.
A competitive BB-ELISA for anti-toxin B neutralising antibodies in assessing risk of recurrent Clostridioides difficile infection: a retrospective cohort study from the MODIFY I and II trials sciencedirect.com/science/ar…
Colonization resistance against Clostridioides difficile is a graded, microbiota-intrinsic property of healthy human gut communities academic.oup.com/ismehm/arti…
Wiep Klaas Smits retweeted
Amazing new work from Carol Gross & team in
@PNASNews
! Several new protein functions discovered! #SubtiWiki
The phenotypic landscape of the model firmicute Bacillus subtilis | PNAS pnas.org/doi/10.1073/pnas.26…
In @eLife: Membrane affinity difference between MinD monomer and dimer is not crucial for MinD gradient formation in Bacillus subtilis doi.org/10.7554/eLife.101520…
Flagellar toxicity: Flagellar synthesis is lytic for Bacillus subtilis in the absence of PBP1 | PNAS pnas.org/doi/10.1073/pnas.26…
Activity-based profiling of bacterial RNA-modifying enzymes reveals species-specific 5-methyluridine modification in Bacillus subtilis 23S rRNA | PNAS pnas.org/doi/10.1073/pnas.26…
The underappreciated role of rifampin in shaping the epidemiology of RT027-like Clostridioides difficile lineages academic.oup.com/jac/article…
The impact of TcdB conformational dynamics
on vaccination against Clostridioides difficile: dx.plos.org/10.1371/journal.…
Type 2 immunity in Clostridioides difficile infection sciencedirect.com/science/ar…
The impact of fecal microbiota transplantation on host immunity and epithelial restoration following Clostridioides difficile infection sciencedirect.com/science/ar…
Wiep Klaas Smits retweeted
Proud and excited to share our first preprint 🚀 in which we
• create a high-fitness firewalled organism,
• that stably colonizes the mouse gut for >100 days,
• resists all tested phages in the gut,
• and blocks horizontal gene transfer.
+ Chimera genomes to tailor synthetic
ALT Firewalled synthetic commensal blocks horizontal gene transfer in the gut