@RemautHan
 Brussels, Belgium
vib.be/en/research/scientists/Pages/Han-Remaut-Lab.aspx
Joined May 2014
  • Tweets453
  • Following249
  • Followers455
27Media
Out Now! Peptidoglycan–outer membrane attachment generates periplasmic pressure to prevent lysis in Gram-negative bacteria bit.ly/4kZA3gF #Peptidoglycan #BacteriaResearch #Microbiology
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Replying to @RemautHan @jrpenades
Thanks, Han! More exciting news coming next week!
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Han Remaut retweeted
RadfordLab@RadfordLab
7 Jan 2025
Great opportunity to join the Radford / Ranson labs and the world-renowned Astbury Centre as a Research Fellow in Structural Biology! Please see jobs.leeds.ac.uk/vacancy.asp…

Jobs at the University of Leeds

jobs.leeds.ac.uk
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Han Remaut retweeted
VIB@VIBLifeSciences
7 Nov 2024
🤯 Specific strains of 𝘌. 𝘤𝘰𝘭𝘪 might contribute to colon cancer. @LarsVereecke @RemautHan @MaudeJans @magdalenakolata and colleagues figure out how. ➡️ Read here vibbio.tech/4hDcYQo @InflamResCen @structbiolbxl @ugent @VUBrussel @FWOVlaanderen @Stkstichting @crighent
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5/6 This was a fantastic collaboration with the @RemautHan lab. Thanks to all who contributed to this work, including @IlievLab, @Joharrr, @SabineTejpar, @GeertBerx 🙏🙏🙏
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🔍 Huge thanks to @kyannaouyang and @JensPuschhof for their insightful News and Views perspective on our study! 🙏🤩 nature.com/articles/d41586-0…

Sticky situation: how adhesive bacteria drive colon cancer

Nature - Adhesion proteins identified that enable bacteria to bind to host cells.

nature.com
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6/6 Special thanks to @Stkstichting , @FWOVlaanderen , @VIBLifeSciences , @crighent, @ugent ,@VUBrussel and @InflamResCen for funding and supporting our work. 🧪🙏🙏
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The feeling is completely reciprocal, absolute pleasure and boost to collaborate with @LarsVereecke lab
Lars Vereecke@LarsVereecke
7 Nov 2024
Replying to @LarsVereecke
5/6 This was a fantastic collaboration with the @RemautHan lab. Thanks to all who contributed to this work, including @IlievLab, @Joharrr, @SabineTejpar, @GeertBerx 🙏🙏🙏
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4/6 🚨 Our findings raise concerns about using E. coli Nissle 1917 as a probiotic. Minimal mutations in Nissle FimH can transform this pks⁺ strain into a highly genotoxic one, potentially increasing cancer risk. A re-evaluation of its safety as a probiotic may be warranted. 🧬⚠️
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3/6 Pharmacological inhibition of FimH effectively blocks bacterial binding, reducing genotoxicity and colon cancer progression. This targeted approach spares beneficial gut microbes, offering a promising therapeutic strategy without the drawbacks of antibiotics. 🚫💊
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2/6 Our study reveals that the adhesins FimH and FmlH are critical for pks⁺ E. coli to bind epithelial cells, enabling colibactin production in close proximity to host DNA. This binding significantly amplifies DNA damage, driving colon cancer development. 🦠🔬
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🎉 Super excited to announce that our study "Colibactin-driven colon cancer requires adhesin-mediated epithelial binding" is now published in Nature! Huge congratulations to first authors @MaudeJans and @magdalenakolata for their fantastic work! 1/6🧵🎉 nature.com/articles/s41586-0…
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I had a great time discussing functional amyloids and presenting my work on #EngineeredLivingMaterials at Vrije Universiteit Brussel @VUBrussel Thanks, @RemautHan, for hosting me!
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Post doc in cryo EM of Amyloid- with @naranson and @AstburyCentre- an exciting opportunity for you to join our collegiate and inspiring team trying to crack amyloid disease by better understanding its formation from test tubes to tissues. Apply here jobs.leeds.ac.uk/Vacancy.asp…
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His accuracy is 100/100
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Published today in @Nature, we describe an approach for single-molecule protein reading on @nanopore arrays. By utilizing ClpX unfoldase to ratchet proteins through a CsgG nanopore, we achieved single-amino-acid sensitivity. nature.com/articles/s41586-0…

Multi-pass, single-molecule nanopore reading of long protein strands

Nature - A technique for threading long protein strands through a nanopore by electrophoresis and back using a protein unfoldase motor, ClpX, enables single protein molecules to be analyzed...

nature.com
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Happy to see the L-ENA story make its way to the Nature Communications website. Great collaboration with NMBU Oslo. @VIBLifeSciences @VUBrussel nature.com/articles/s41467-0…

Helical ultrastructure of the L-ENA spore aggregation factor of a Bacillus paranthracis foodborne...

Nature Communications - The pathogenic Bacillus paranthracis NVH 0075-95 produces pili-like (L-ENA) structures on its spore surface to mediate spore-spore contacts. Using cryoEM, a molecular model...

nature.com
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This #preprint by Jolyon Claridge, @RemautHan, @MikeSleutel, and colleagues @VUBrussel has recently been reviewed by @BiophysicsColab You can read the report by clicking on 'TRiP Peer Reviews' in bioRxiv: biorxiv.org/content/10.1101/…

The folding-limited nucleation of curli hints at an evolved safety mechanism for functional amyloid...

It is nearly two decades ago that the ‘thin aggregative fimbriae’ which had been shown to enhance the biofilm formation of Salmonella enteriditis and Escherichia coli were identified as amyloid...

biorxiv.org
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Looking for a postdoc excited about the structural biology of bacterial biofilms and cyclic dinucleotide signaling. We are a small but diverse and passionate team, have access to high-end facilities and provide hands-on training in a variety of techniques. Repost & DM 🙏🙏🙏
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Han Remaut retweeted
Neil Ranson@naranson
17 Feb 2024
Interested in membrane protein structure, folding, interactions and function? We're looking for a creative, talented post-doc to join our bacterial outer membrane team @RadfordLab @naranson in the @AstburyCentre, on a new @The_MRC programme grant. jobs.leeds.ac.uk/Vacancy.asp…

Jobs at the University of Leeds

jobs.leeds.ac.uk
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