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Val Pye

@val_pye
Joined July 2019
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Delighted to share that our manuscript describing the structural dynamics of SAMHD1 catalysis using time-resolved cryoEM and extensive biophysics is now available online. Fantastic collaboration between several labs and STPs @TheCrick nature.com/articles/s41467-0…

Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis

Nature Communications - SAMHD1 is a regulator of dNTP homeostasis and an HIV restriction factor. The authors use time-resolved cryo-EM to visualise dynamic conformational changes that drive the...

nature.com
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You can request a free SHINY, PURPLE and LIMITED EDITION pin from @thermofisher below, in celebration of women scientists in #ElectronMicroscopy for #InternationalWomensDay2024 Bonus points if you post a photo with your pin #EmpowerWomenInEM bit.ly/49HcBzF
Image from Rebecca Thompson (@Bex_16)
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Still time to apply for this post doc position in our lab. Deadline 9th February.
Aravindan Ilangovan (@ilango_aravind) profile pictureAravindan Ilangovan@ilango_aravind19 Jan 2024
We are looking for a Postdoctoral Research Associate with expertise in cryo-EM/cryo-ET to join our lab at @QMULSciEng . This @wellcometrust funded post is aimed at studying the DNA replication initiation mechanism in bacteria. Please RT. qmul.ac.uk/jobs/vacancies/it…
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'Building' up to the Holiday Season - Day 15. Protein Structure Determination at Peak Proteins (part of Sygnature Discovery). This structure is ATP synthase which catalyses the formation of the energy storage molecule adenosine triphosphate (ATP).
Image from Peak Proteins (@PeakProteins)
Peak Proteins (@PeakProteins) profile picturePeak Proteins@PeakProteins14 Dec 2023
'Building' up to the Holiday Season - Day 14. NMR at Peak Proteins (part of Sygnature Discovery). We’re very excited to be offering NMR data collection and interpretation for our clients and have a number of projects underway. 🙌🏽🧲
Image from Peak Proteins (@PeakProteins)
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Excited to share our recent work on bacterial DNA replication initiation published in @NatureComms. Great collaborative effort with @heathmurraylab key contribution from @YardimciLab. Good team work overall @simopelliciari @Ch_Winterhalter Salome and Yumi doi.org/10.1038/s41467-023-4…
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'Building' up to the Holiday Season - Day 6. Protein Expression and Purification at Peak Proteins (part of @SygnatureDiscov ). At Peak Proteins we can express and purify proteins from E. coli, insect and mammalian cells. lnkd.in/d5Qa27t7
Image from Peak Proteins (@PeakProteins)
Peak Proteins (@PeakProteins) profile picturePeak Proteins@PeakProteins6 Dec 2023
Day. 5 'Building' up to the Holiday Season - Day 5. Mass Spectrometry at Peak Proteins (part of Sygnature Discovery). In addition to part of our QC, we offer Mass Spectrometry as a standalone service. Find out more lnkd.in/d4GittbV
Image from Peak Proteins (@PeakProteins)
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A Crick team including @ghostpathogen @MuraliMaradana @SaterialeLab and Gitta Stockinger have found that high levels of a molecule commonly found in cruciferous vegetables like broccoli could offer protection against the Cryptosporidium parasite 🥦🛡️🪱 crick.ac.uk/news-and-reports…
Common dietary supplement could protect against Cryptosporidium parasite infection

Common dietary supplement could protect against Cryptosporidium parasite infection

Researchers at the Francis Crick Institute have discovered that a common dietary supplement could protect against chronic Cryptosporidium infections which are particularly prevalent in children under...

crick.ac.uk
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'Building' up to the Holiday Season - Day 4. At Peak Proteins we use the Fida 1 platform from @FIDATechnology for a number of our client projects. 📖Read more about how we use Fidabio lnkd.in/eKy28Q_4
Image from Peak Proteins (@PeakProteins)
Peak Proteins (@PeakProteins) profile picturePeak Proteins@PeakProteins3 Dec 2023
'Building' up to the Holiday Season - Day 3. We have a dedicated team of membrane protein scientists. Along with our colleagues at @SygnatureDiscov we recently published a review in, focused on the key aspects of modern GPCR drug discovery. lnkd.in/dTJWaFrJ
Image from Peak Proteins (@PeakProteins)
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'Building' up to the Holiday Season - Day 2. Day 2 - Horseshoe Crabs and Endotoxins! At Peak Proteins (part of @SygnatureDiscov), we are experienced in minimising endotoxin levels where required by our clients for assays. Read to learn more ! lnkd.in/et3JTn9T
Image from Peak Proteins (@PeakProteins)
Peak Proteins (@PeakProteins) profile picturePeak Proteins@PeakProteins1 Dec 2023
'Building' up to the Holiday Season - Day 1. We're counting down to the holidays with a series of models highlighting what we do at Peak Proteins (part of @SygnatureDiscov ). First up is our bioreactor @InforsUK - read more peakproteins.com/labfors5-be…
Image from Peak Proteins (@PeakProteins)
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'Building' up to the Holiday Season - Day 1. We're counting down to the holidays with a series of models highlighting what we do at Peak Proteins (part of @SygnatureDiscov ). First up is our bioreactor @InforsUK - read more peakproteins.com/labfors5-be…
Image from Peak Proteins (@PeakProteins)
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Agar Plate Art! Recently Peak Proteins' scientists got creative and designed and produced bacterial art for entrance into the @ASMicrobiology 's “Microbiology in Space" Agar Art Contest. 🚀🦠🎨 peakproteins.com/peak-protei…
Drug Discovery Research Blog | Sygnature Discovery

Drug Discovery Research Blog | Sygnature Discovery

Read scientific perspectives from Sygnature researchers on the ideas, methods and challenges shaping modern drug discovery. Click here to learn more.

sygnaturediscovery.com
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If you are interested in using #CryoEM and #Chemistry to study PROTACs for cancer treatment do a iCASE #PhD with James Hodgkinson, John Schwabe and me @LeicStructBio and @PeakProteins. Click here and scroll to the bottom ⬇️🔬more.bham.ac.uk/mrc-aim/phd-…
@MRC_AIM_DTP (@Impact_Aim_Mrc) profile picture@MRC_AIM_DTP@Impact_Aim_Mrc27 Nov 2023
🚨We are delighted to announce that recruitment for 2024 studentships is now open! Projects are across the 3 partner institutions @unibirmingham @uniofleicester and @UniofNottingham Application forms and information are available on the AIM website tinyurl.com/3x4zj3zk 🧵
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Thrilled to share this review with @LMSpenkelink & @van_Oijen on the advancements in single-molecule approaches & cryo-EM🔬. These technologies are reshaping our understanding of DNA replication dynamics! #StructuralBiology #Biophysics #AcademicChatter pubs.acs.org/doi/full/10.102…
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New from us! @TheCrick Houghton, F.M., et al. Architecture and regulation of a GDNF-GFRα1 synaptic adhesion assembly. doi.org/10.1038/s41467-023-4… nature.com/articles/s41467-0… #CryoEM #CryoET #MX #Crystallography #StructuralBiology #Neurology #Glycotime #Science #SeeMyScience
Architecture and regulation of a GDNF-GFRα1 synaptic adhesion assembly

Architecture and regulation of a GDNF-GFRα1 synaptic adhesion assembly

Nature Communications - The soluble neurotrophic factor GDNF promotes trans-synaptic adhesion through its co-receptor GFRα1. Here, the authors describe the structural basis for GDNF-GFRα1...

nature.com
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Our study on the cover of Molecular Cell 🥳. Thanks @AgaGambus and @GS_Lab_Bham for a great collaboration. Structure by Milos Cvetkovic❄️, @PaoloPassaretti🧬, Agata Butryn👩‍🔬. Artwork by @petermindek and the nanographics.at team.
Molecular Cell (@MolecularCell) profile pictureMolecular Cell@MolecularCell16 Nov 2023
Our latest issue is out now! cell.com/molecular-cell/curr…
Image from Molecular Cell (@MolecularCell)
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Excited to share another paper from my time @TheCrick! Thanks to everyone involved, @e_almacellas @Stefano_De_Tito @val_pye @Alex_van_Vliet @sharontooze01. Looking forward presenting this work @LivUniISMIB next week. #autophagy #atg9 #atg2 #lipid #scramblase
George Chiduza (@ChiduzaGeorge) profile pictureGeorge Chiduza@ChiduzaGeorge10 Nov 2023
Autophagy is a conserved degradation pathway in eukaryotes. However mammals have two copies of the lipid scramblase ATG9. We report here a detailed molecular and functional characterization of the more rapidly evolving and understudied paralog, ATG9B. doi.org/10.1080/15548627.202…
ATG9B is a tissue-specific homotrimeric lipid scramblase that can compensate for ATG9A

ATG9B is a tissue-specific homotrimeric lipid scramblase that can compensate for ATG9A

Macroautophagy/autophagy is a fundamental aspect of eukaryotic biology, and the autophagy-related protein ATG9A is part of the core machinery facilitating this process. In addition to ATG9A vertebr...

tandfonline.com
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Our latest paper uses structural biology, biochemistry & biophysics to reveal the two-step catalytic mechanism of the human nucleotide pool sanitiser DNPH1. This will aid the development of novel inhibitors, which may be of use in breast cancer treatment. nature.com/articles/s41467-0…
Image from The West Lab (@SCWestLab)
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Thrilled to present our manuscript out today in @CellCellPress. A tour-de-force on anaphylatoxin complement receptors - 9 (!!!) unique GPCR structures: C3aR/C5aR1, biased/partial/full agonist, Go/Gq, mouse/human. doi.org/10.1016/j.cell.2023.…
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DONSON paper out! Congratulations Milos Cvetkovic and @PaoloPassaretti! Great collaboration with @AgaGambus's group. Thanks @GS_Lab_Bham for contributing. The structural mechanism of dimeric DONSON in replicative helicase activation: @MolecularCell cell.com/molecular-cell/full…
Image from Costa Lab (@CostaLabCrick)
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Very happy to share our new study with Alessandro Costa lab. Structural aspects of DONSON function during replication initiation. Great job @PaoloPassaretti, Milos Cvetkovic and the rest of the teams! sciencedirect.com/science/ar…
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