@wellcometrust Early Career Fellow working on bacterial DNA damage repair @CBCB_Newcastle @UniofNewcastle. @winterhalterlab.bsky.social
Joined April 2014
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Still time left to apply and join my team on a fully funded PhD project investigating dynamics of the bacterial DNA damage response in live cells using microscopy & genomics
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Excited to share with you the story that enabled me to start my own lab: what happens when the bacterial DNA replication machinery encounters single-strand discontinuities on template DNA? What is required for DNA break repair and replication restart? biorxiv.org/content/10.1101/…
Charles Winterhalter retweeted
Come and do a PhD with me and @DrPaulJamesUK to find some new exciting enzymes! #glycotime
findaphd.com/phds/project/ne…
Charles Winterhalter retweeted
If you're interested in chromosome biology (DNA folding, gene regulation, replication, polymer modelling and more) we're organising the below this autumn. It'd be great to see you there. Please share if you can. :-)
Navigating through academia as an ECR can be challenging. @CKYLau and @CorreiaMeloC will tell us more about their experience of becoming group leaders and how to achieve this on 12th Feb @BiochemSoc. Free registration at
attendee.gotowebinar.com/reg…
Charles Winterhalter retweeted
Using cryoEM we understood the structural basis of chiral DNA wrap by bacterial gyrase (and also produced the most complete/highest resolution E coli gyrase model to date).
@JohnInnesCentre @DurhamU34989 @MCB_UJ
Charles Winterhalter retweeted
2 weeks to go! Apply for the 2 posts by Nov 25th - pls RT!
We have 2 postdoc openings for an imaging biophysist and a data scientist at @kavlioxford. Intrigued by super-res microscopes🔬, single molecules, RNA, condensates, AI and bacteria 🦠? Read on! #ScienceJobs #Postdoc #bacteria #singlemolecule Pls RT.
Fully-funded @DiMeN_DTP PhD opportunity available in my lab to investigate novel DNA damage repair processes using next generation sequencing and microscopy techniques (co-supervised by @acdarby & @MicKasia). Please RT and contact me if interested.
findaphd.com/phds/project/mr…
Charles Winterhalter retweeted
We are very excited to announce our latest work on how MRSA conquers antibiotics. We show that high-level resistance to methicillin requires S. aureus to utilise an alternative mode of cell division to ensure its survival! @Sheffield_AFM @Olulana4
doi.org/10.1126/scienc…
Charles Winterhalter retweeted
As well as improving our daily lives, university research contributes £54 BILLION to the UK economy and supports 121k jobs across the UK📈
If we want to be a country fit for the future, the government must make research funding more sustainable👇
loom.ly/T-7pw68
Charles Winterhalter retweeted
DTP PhD studentship available in our lab. Start: Oct 2025. Apply: now-24th Nov 2024
Taming the Viral Wolf: Cracking the Code of Gene Transfer Agents in Bacteria.
Please RT. Thank you!!!
shorturl.at/sR2px
If you haven't already, check out the Hachiman phage defence system characterised by the @doudna_lab @CellCellPress. Inspiring work and scary 'phantom' cells (perfect for Halloween!) 👏
cell.com/cell/fulltext/S0092…
Charles Winterhalter retweeted
Please RT. 1x postdoc and 1xPhD position available in our group to study the role of NLR-like proteins in cellular development and antibiotic production in Streptomyces.
Postdoc: shorturl.at/f8NTN
PhD position: shorturl.at/qCFmN
Email me for more information.
Super nice Single Molecule Bacteriology meeting in the Cotswolds. Thanks to the organisers, looking forward to new collaborations and see you at the next event!
That's a wrap on the 91st Harden: Single Molecule Bacteriology event!
Huge thanks to everyone who joined us for insightful talks, lively discussions and lots of fun! #biochemevent
ALT 91 Harden group photo
Looking forward to day 2 at the UK DNA Replication Meeting for more amazing talks! Come and find me this evening at Poster 4 to hear all about replisome arrest and replication restart from nicks @BiochemSoc #BioChemEvent
Registration for the Single Molecule Bacteriology III conference is open, I am honoured to be invited speaker and looking forward to meet you all there!
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Charles Winterhalter retweeted
A high-resolution view of how replication-coupled DNA breaks are generated, processed and repaired. Congrats to @pavani_raphael, @TripathiVeenu, and many terrific collaborators including @FrogWalterLab, @CejkaLab, @weiwsmiling. See science.org/doi/epdf/10.1126…
Charles Winterhalter retweeted
A rewarding collaboration revealing an entirely novel inhibitor pocket in DNA gyrase. Inhibition mechanism determined via beautiful biochemistry experiments by @leela_bg - well done Leela! Thanks to @yushuv @AstburyCentre for the final EM data collection 👍
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Charles Winterhalter retweeted
Our work on elucidating transcriptional control of Gene Transfer Agents GTA in Caulobacter crescentus is finally published… nature.com/articles/s41467-0…
Charles Winterhalter retweeted
It's time for a new era of ambitious global action on antimicrobial resistance (AMR).
The cost of inaction is too high.
Political leaders must set bold targets and establish better ways to monitor evidence and progress.
Read our recommendations ⤵️
wellcome.org/reports/driving…
