McDonald Lab @ The Crick (@LabMcDonald) header
McDonald Lab @ The Crick (@LabMcDonald) profile picture

McDonald Lab @ The Crick

@LabMcDonald

We use structural and mechanistic biology to study neurotrophic receptors, Rho-effector kinases, and a few other things too @TheCrick. -- run by lab members --

Joined May 2019
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New from us! @TheCrick Houghton, F.M., et al. Architecture and regulation of a GDNF-GFRα1 synaptic adhesion assembly. doi.org/10.1038/s41467-023-4… nature.com/articles/s41467-0… #CryoEM #CryoET #MX #Crystallography #StructuralBiology #Neurology #Glycotime #Science #SeeMyScience
Architecture and regulation of a GDNF-GFRα1 synaptic adhesion assembly

Architecture and regulation of a GDNF-GFRα1 synaptic adhesion assembly

Nature Communications - The soluble neurotrophic factor GDNF promotes trans-synaptic adhesion through its co-receptor GFRα1. Here, the authors describe the structural basis for GDNF-GFRα1...

nature.com
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NEW from us @TheCrick! Capture, mutual inhibition and release mechanism for aPKC-Par6 and its multi-site polarity substrate Lgl | bioRxiv #Science #Research #StructuralBiology #CryoEM #Crystallography #Polarity #Cancer biorxiv.org/content/10.1101/…
Image from McDonald Lab @ The Crick (@LabMcDonald)
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These proteins all form part of a cell polarity network, which allows cells to determine "which way is up" - so (for example) the cells lining your gut know which side the food is.
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Cell polarity is frequently disrupted in cancers, and aPKC iota is a potential therapeutic target, so the more we know about how it works, the better we can target those cancers.
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McDonald Lab @ The Crick retweeted
The Francis Crick Institute (@TheCrick) profile picture
The Francis Crick Institute@TheCrick26 Sep 2024
Sandwich student applications are open until 9 October! We’re looking for motivated undergraduates studying biology, physics, chemistry, engineering, maths or computer science to join a Crick research group or facility for their placement year 🧪📊🔬 crick.ac.uk/careers-study/st…
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McDonald Lab @ The Crick retweeted
Greg Findlay (@TheGenomeLab) profile picture
Greg Findlay@TheGenomeLab27 Sep 2024
Crick PhD recruitment for fall 2025 is officially open! Please apply to our lab through the Crick application portal if interested. 👇 crick.ac.uk/careers-study/va…
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McDonald Lab @ The Crick retweeted
Mathias Cobbaut (@m_cobbaut) profile picture
Mathias Cobbaut@m_cobbaut19 Dec 2023
Hot off the press in @Biochem_Journal where we discuss new insights into aPKC membrane targeting. These PKCs do not bind DAG to get recruited, instead they fold up their regulatory elements exposing a single membrane binding platform! read on here👇doi.org/10.1042/BCJ20230390

Into the fold: advances in understanding aPKC membrane dynamics

Atypical protein kinase Cs (aPKCs) are part of the PKC family of protein kinases and are atypical because they don't respond to the canonical PKC activators diacylglycerol (DAG) and Ca2+. They are...

portlandpress.com
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(If you wish to engage with us about our work, you might consider looking up the authors on Linkedin or other social media platforms - may we suggest the one run by proboscideans belonging to the genus Mammut 🦣🦣🦣 - xtaldave_dot_net)
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The soluble neurotrophic factor GDNF is able to drive trans-synaptic adhesion through its co-receptor GFRa1. Here we describe the structural basis for GDNF-GFRa1 adhesion and reconstitute assemblies bridging membranes. D5 Symmetry! A 10:10 complex!
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We then demonstrate that binding of either the RET receptor or proteoglycans can disrupt this adhesive function.
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McDonald Lab @ The Crick retweeted
McDonald Lab @ The Crick (@LabMcDonald) profile picture
McDonald Lab @ The Crick@LabMcDonald11 Oct 2022
Fancy doing a PhD with us @TheCrick? We have a studentship available studying Receptor Tyrosine Kinase function and modulation, to start in Autumn 2023. #StructuralBiology #CryoEM #MX Application deadline noon (GMT) 10th November. For details see: crick.ac.uk/careers-study/va…
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Structural Biology rant - structures are ‘determined’ not ‘solved’. It is problems e.g. phase or molecular replacement that are solved along the route to determining a structure. There the old man is feeling better now
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McDonald Lab @ The Crick retweeted
Julian Downward (@JulianDownward) profile picture
Julian Downward@JulianDownward13 Oct 2022
Interested in how cancers control the immune system? We have a PhD studentship open at the Francis Crick Institute in London to study KRAS oncogene mutant lung cancer and immunotherapy. Apply to join our team by 10 November. #Downwardlab @TheCrick crick.ac.uk/careers-study/va…
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We've spent the last few days interviewing some MRes Structural and Molecular Biology students from Imperial College. Impressive bunch! No matter which student is allocated to our (exciting XChem) project, we're sure they'll do well!
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Fancy doing a PhD with us @TheCrick? We have a studentship available studying Receptor Tyrosine Kinase function and modulation, to start in Autumn 2023. #StructuralBiology #CryoEM #MX Application deadline noon (GMT) 10th November. For details see: crick.ac.uk/careers-study/va…
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Good to see McDonald Lab alumnus @mljones1993 hitting the headlines with Joe Yeeles at the LMB.
Medical Research Council (@The_MRC) profile pictureMedical Research Council@The_MRC1 Jun 2022
Scientists at @MRC_LMB have for the first time recreated a functional human replisome - the protein machinery that normally replicates human DNA within a cell - that successfully replicated DNA in the lab at the same speed as inside our cells. ➡️ orlo.uk/8aq0M
Image from Medical Research Council (@The_MRC)
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McDonald Lab @ The Crick retweeted
Sam Horrell 🗿 (@DrHorrell) profile picture
Sam Horrell 🗿@DrHorrell27 Apr 2022
Well... It looks like we have our first ever draw in #SynchrotronMugMadness. Now I have a choice to make. Run the poll again or go for a 3 way final between @desy, @esrfsynchrotron, and @ausynchrotron. Suggestions welcome. Stay tuned to find out!
Sam Horrell 🗿 (@DrHorrell) profile pictureSam Horrell 🗿@DrHorrell26 Apr 2022
The second semi final match of #SynchrotronMugMadness is now upon us. Today sees Europe facing off against Australasia with @esrfsynchrotron vs @ausynchrotron! Who will go on to face @desy or the @EuropeanXFEL in the final? Please vote, like and share your favourites!
50%ESRF
50%Aussie-tron
584 votes • Final results
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Preprint from collaborators on the role of RET in axonal transport and the potential of RET inhibition as a therapeutic target for ALS. The good news is that there are a number of extensively studied RET inhibitors already approved for cancer treatment!
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13 years after we determined the structure of 9-1-1 Matt Day, @antonywoliver and me are delighted to offer the structure of human 9-1-1 bound to its RAD17-RFC clamp loader and engaged with a dsDNA-ssDNA junction shrtm.nu/sDCk
Image from Laurence Pearl 🔥💚🚣‍♀️🛶♊️ (@laurencepearl)
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