@CostaLabCrick

Biochemists & cryo-EM scientists studying chromosome replication @TheCrick

 The Francis Crick Institute
alecostalab.net
Joined October 2022
  • Tweets59
  • Following134
  • Followers504
8Media
I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication. 8 years of funding at the Crick Institute. Looking for a postdoc in molecular mechanism, cryo-EM and in situ structure? Contact me now! 3 postdoc positions advertised soon.
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How does ATP hydrolysis by MCM enable replicative helicase loading onto DNA? Find the answer in our latest article rdcu.be/d6D8D Congratulations to Agata Butryn, who spearheaded the entire project, Contributions from @GreiweJulia in the early days. 🎉❄️🔬🧬
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crick.ac.uk/news-and-reports…

Wellcome Discovery Award given to Alessandro Costa for research on DNA replication

Crick group leader Alessandro Costa has been awarded a Wellcome Discovery Award for £3m over eight years to study DNA replication using cutting-edge imaging technologies.

crick.ac.uk
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Our article "MCM double hexamer loading visualized with human proteins" published in Nature today! ❄️🔬🧬🎉🥳 Great collaboration with John Diffley's lab. Congratulations to Florian Weissmann, Julia Greiwe and all other authors! rdcu.be/d1F7m
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Our study on how the human MCM2-7 helicase is loaded onto replication origins 🧬 is now online @Nature! 🎉 Our findings reveal that unlike in yeast, human MCM loading does not require ORC6 and can occur through multiple pathways. Read more here: rdcu.be/d1F6S
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Great kickoff for the EMBO EMBL Replication symposium with amazing structural and functional insights into initiation, elongation and histone recycling 🧬♻️ @TyeBik @CostaLabCrick @BleichertLab @Speck_Lab Chistol @Lopes_Lab Méchali @YardimciLab 🙌 #EESReplication @EMBLEvents
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Looking forward to this!
Rafa F Leiro@rfleiro
6 Sep 2024
A fantastic lineup of speakers for the "Machines acting on DNA and RNA" meeting at @CNIOStopCancer All things D/RNA! 🧬Replication + transcription + translation + chromatin + repair + processing🧬 May 28th to 30th, 2025 - Save the date! @OscarLlorcaCNIO @rfleiro @NogalesLab
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⏰ Deadline approaching for #EESReplication ⏰ Submit your abstract by 13 August and find out about the latest breakthroughs in DNA replication 🧪🧬 📅 5 – 8 November 📍 EMBL Heidelberg and Virtual ➡️ s.embl.org/ees24-12
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Congratulations to group leaders Snezhka Oliferenko and Alessandro Costa (@CostaLabCrick) on being elected as members of @EMBO 🥳 crick.ac.uk/news-and-reports…

Two Crick group leaders elected as EMBO members

Crick group leaders Alessandro Costa and Snezhka Oliferenko have been elected members of the European Molecular Biology Organisation (EMBO).

crick.ac.uk
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Costa Lab retweeted
Tom Deegan@TDDeego
8 Jul 2024
Abstract and early bird deadline for the 2024 UK DNA Replication Meeting is this week. Don't miss out - its going to be a fantastic meeting!
Biochemical Society@BiochemSoc
2 Feb 2024
Unlock the latest insights into DNA replication at our 2024 meeting. Dive into the forefront of research and deepen your understanding of this fundamental process. Register today to join leading experts and explore rapid advancements. ow.ly/jaOL50Qvt9K
A Biochemical Society Scientific Meeting UK DNA Replication Meeting 2024 10-12 September 2024, Cambridge, UK Register online: bit.ly/DNARep24 Abstract and Earlybird deadline: 10 July 2024

ALT A Biochemical Society Scientific Meeting UK DNA Replication Meeting 2024 10-12 September 2024, Cambridge, UK Register online: bit.ly/DNARep24 Abstract and Earlybird deadline: 10 July 2024

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How does Mcm10 activate an origin of replication? Find the answer in our paper published today in @NatureSMB. Congratulations to Sarah Henrikus & our fantastic lab! 🥳🎉 rdcu.be/dIdI4 Great collaboration with Marta, Allie and John from @DiffleyLab @TheCrick
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TWO postdoc positions available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in biochemistry/structural biology/cell biology to work on these exciting projects! Post 1: DNA damage response my.corehr.com/pls/uoxrecruit…
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Human origin licensing reconstituted with purified proteins. Great collaboration with Florian Weissmann & John @DiffleyLab. A cryo-EM tour de force from our @GreiweJulia.
bioRxiv@biorxivpreprint
11 Apr 2024
MCM Double Hexamer Loading Visualised with Human Proteins biorxiv.org/cgi/content/shor… #bioRxiv
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I am happy to announce that we've recently posted our new manuscript, titled: ‘Cell Cycle Regulation has Shaped Budding Yeast Replication Origin Structure and Function’ on BioRxiv (biorxiv.org/content/10.1101/…). We hope you enjoy! Tweetorial below:
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🌟 Big News! 🌟 the Lewis lab is open for business @MolHorizons. A new chapter of discovery and learning awaits. Thrilled to start this journey and tackle some challenging questions!
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Our study on the cover of Molecular Cell 🥳. Thanks @AgaGambus and @GS_Lab_Bham for a great collaboration. Structure by Milos Cvetkovic❄️, @PaoloPassaretti🧬, Agata Butryn👩‍🔬. Artwork by @petermindek and the nanographics.at team.
Molecular Cell@MolecularCell
16 Nov 2023
Our latest issue is out now! cell.com/molecular-cell/curr…
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DONSON paper out! Congratulations Milos Cvetkovic and @PaoloPassaretti! Great collaboration with @AgaGambus's group. Thanks @GS_Lab_Bham for contributing. The structural mechanism of dimeric DONSON in replicative helicase activation: @MolecularCell cell.com/molecular-cell/full…
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Costa Lab retweeted
FASEB
@FASEBorg
16 May 2023
The deadline for abstract submissions has been extended to this Sunday (5/21). Share cutting-edge research on RNA and DNA helicases for a short talk or an in-person poster/e-poster. #HNASRC @PaeschkeL @Trakselis @tranforwabash Register and submit: bit.ly/3McTlQg
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Interested in Structure, Mechanism and Chromosome Biology? Then you should join our lab at the Crick as a PhD student! crick.ac.uk/careers-study/va… Applications close on 22 March 2023. You might get a hat like Julia's, who successfully defended her thesis last week! 🥳❄️🔬🧬
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Congratulations to our PhD student Julia Greiwe for receiving the Crick Science Achievement Award. As part of the celebrations, Julia gave a great talk at the Crick Autumn Science Meeting last week. She described the mechanisms MCM helicase loading and phosphorylation by DDK.
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