@suminkim28

Postdoc @hansen_lab. PhD @UMichCMB. Fascinated by the nucleus, organelles, neurons, and imaging 🔬. Working on improving DEI for trainees. she/her.

 Cambridge, MA
Joined April 2013
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Excited to share my thesis work! Using super-resolution microscopy and a new HaloTag-Nup107 mouse line, we find that 1) NPC biogenesis is upregulated during neuronal maturation and that 2) torsinA is essential for normal localization and assembly kinetics of neuronal NPCs. (1/N)
bioRxiv Cell Biology@biorxiv_cellbio27 Apr 2023
TorsinA is essential for the timing and localization of neuronal nuclear pore complex biogenesis biorxiv.org/cgi/content/shor… #biorxiv_cellbio
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💫NEW: @BillDauerNeuro, @pappassa, @BarmadaLab, @suminkim28, @UTSWBrain & co show that Torsin A is required for the maturation and normal localization of nascent #neuronal #NuclearPoreComplex. 👉🏿rdcu.be/dSPKD nature.com/articles/s41556-0…
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So happy and relieved that this is now out in nature.com/articles/s41556-0…! Thanks to all authors esp Tri, @ShahmoraLab for help w revisions, and mentors @BarmadaLab, @pappassa, and @BillDauerNeuro for continued support. Also thanks to the reviewers who had thoughtful suggestions.
Sumin Kim@suminkim2828 Apr 2023
Excited to share my thesis work! Using super-resolution microscopy and a new HaloTag-Nup107 mouse line, we find that 1) NPC biogenesis is upregulated during neuronal maturation and that 2) torsinA is essential for normal localization and assembly kinetics of neuronal NPCs. (1/N)
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Very proud of Ava on her successful summer project and poster presentation! 😄
ASHansen Lab@hansen_lab2 Aug 2024
Congrats to Ava @AvaConyer on a fantastic MSRP poster presentation on the polycomb work she did together with Sumin @suminkim28 !
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Very neat approach and beautiful movies!
Andy Moore@aaandmoore11 Jun 2024
Excited to share our new preprint with @BuvanSR and @volodya_gelfand! 🎉 Using a sparse vimentin SunTag labeling strategy and 3D FIB-SEM reconstructions, we do a deep dive on vimentin IF dynamics and nanoscale organization in cells. #CellBiology biorxiv.org/content/10.1101/…
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Elizabeth Villa@TheVillaLab28 Mar 2024
It cannot be done, they said.. It's too flexible, they said.. 😁 biorxiv.org/content/10.1101/… #NPC #teamtomo #integrativemodeling by @dgvjayS @neeleshsoni03 @JoshHutchings94 @ig_ech et al. Great collaboration w/ Qiang Guo, Brian Chait, Javi Fernandez-Mtnz, @RoutLab_RU @salilab_ucsf

The Molecular Architecture of the Nuclear Basket

The nuclear pore complex (NPC) is the sole mediator of nucle-ocytoplasmic transport. Despite great advances in understanding its conserved core architecture, the peripheral regions can exhibit...

biorxiv.org
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Sumin Kim retweeted
deWitLab@deWitLab13 Mar 2024
You may know ZNF143 as a looping factor. We show together with the @hansen_lab that this is not the case! If you want to know why and what it does instead do read our thread below: biorxiv.org/content/10.1101/…

ZNF143 is a transcriptional regulator of nuclear-encoded mitochondrial genes that acts independen...

Gene expression is orchestrated by transcription factors, which function within the context of a three-dimensional genome. Zinc finger protein 143 (ZNF143/ZFP143) is a transcription factor that has...

biorxiv.org
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Exciting and important work by @DomenicNarducci —
Anders Sejr Hansen@Anders_S_Hansen12 Mar 2024
(1/14) Excited to share our new work on ZNF143/ZFP143 by @DomenicNarducci ZNF143 has been widely reported to be a general loop factor Instead we and @deWitLab in a companion preprint show that ZNF143 is a TF with no loop function: biorxiv.org/content/10.1101/… biorxiv.org/content/10.1101/…
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(1/n) Excited to share our new review by @JinHarveyYang @NatRevMCB We discuss: 1) spatiotemporal mechanisms of E-P interactions 2) mechanisms of enhancer selectivity 3) pros and cons of 3C and imaging based methods Brief summary thread below: nature.com/articles/s41580-0…
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My autobiography is now published on the @NobelPrize website. It covers both my personal and professional life, highlighting the decisions and events that have had the biggest impact. I appreciate the opportunity to tell my story. Hope you enjoy reading it nobelprize.org/prizes/medici…

Nobel Prize in Physiology or Medicine 2021

The Nobel Prize in Physiology or Medicine 2021 was awarded jointly to David Julius and Ardem Patapoutian "for their discoveries of receptors for temperature and touch"

nobelprize.org
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Hasper et al. @abbybuch lab @UCSF show that the mutation that causes Hutchinson–Gilford progeria syndrome slows lamin A/C protein turnover in #disease-afflicted tissues, causing the mutant protein to accumulate over time. bit.ly/3G2iVEI #ProteinHomeostasis
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Come and join us! We are looking to recruit a Research Assistant/Technical Associate I to join our team Summer 2024. This could be an ideal position for someone looking for 2 years of research experience before starting graduate school. Apply: careers.peopleclick.com/care…
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RT if you don't mind!! ~~ Does anyone know of a genome-wide genetic screen, or proteomics dissection, targeting for molecules required for nuclear envelope breakdown in proliferating cells of animals? Any thoughts appreciated!!
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I’m excited to share that my PhD paper is now published in @NatureComms! I’m grateful for the support of all collaborators, in particular my advisor @shiner80, Alessia Loffreda, and Emanuele Colombo. See this thread for more details, and read the paper at nature.com/articles/s41467-0…

Chromatin organization drives the search mechanism of nuclear factors

Nature Communications - Nuclear factors rapidly scan the genome for targets, but the role of nuclear organization in such search is uncharted. Here, by combining single molecule tracking of nuclear...

nature.com
Davide Mazza@shiner8013 Oct 2023
...And the manuscript is now out in @NatureComms: nature.com/articles/s41467-0…. Here a long-due but (hopefully) short thread:

Chromatin organization drives the search mechanism of nuclear factors

Nature Communications - Nuclear factors rapidly scan the genome for targets, but the role of nuclear organization in such search is uncharted. Here, by combining single molecule tracking of nuclear...

nature.com
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Super excited to start as a postdoc in @hansen_lab today! Looking forward to working with this fantastic group of scientists, and the view is pretty great too ☺️
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Excited to share that I defended my thesis today and became the first Dr. in my family! 😊 Many many thanks to my mentors @BillDauerNeuro and @BarmadaLab!
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Had a fantastic time at #celldyn2023, a big thanks to the organizers and @Co_Biologists! Feeling energized after meeting so many awesome scientists, and loved exploring the beautiful Lisboa and surroundings ☺️
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Replying to @ChristinaAdele6
@ChristinaAdele6 @lab_ogden kicked off the final session of #celldyn2023 dissecting the mechanism of SHH-dependent cytoneme formation. Next up, @suminkim28 showed the role for TorsinA in neuronal nuclear pore biogenesis with disease implications. Preprint: biorxiv.org/content/10.1101/…
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1/n Our Region Capture Micro-C (RCMC) preprint by @ViraatGoel @mileshuseyin is out today in @NatureGenet at rdcu.be/dbEuM See also MIT News story at news.mit.edu/2023/unpreceden… with a nice 2-min video explainer youtube.com/watch?v=oybAJIeV… More details below:
Anders Sejr Hansen@Anders_S_Hansen15 Jul 2022
(1/n) Excited to share preprint by @ViraatGoel @mileshuseyin We develop Region-Capture Micro-C (RCMC) By focusing on specific regions, we generate the deepest 3D genome maps thus far We see coalescence of enhancer and promoters into “microcompartments” biorxiv.org/content/10.1101/…
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thanks Bill!
Bill Dauer@BillDauerNeuro27 Apr 2023
Congrats to @suminkim28 who led this cool work revealing the dynamics of the neuronal nuclear pore and identified a novel aspect of torsinA biology. Hat tip also to @pappassa who played essential role biorxiv.org/content/10.1101/… @UTSWBrain @UTSWNeurosci

TorsinA is essential for the timing and localization of neuronal nuclear pore complex biogenesis

Nuclear pore complexes (NPCs) regulate information transfer between the nucleus and cytoplasm. NPC defects are linked to several neurological diseases, but the processes governing NPC biogenesis and...

biorxiv.org
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As for the functional consequences: delayed NPC assembly may interfere with neurodevelopmental processes that depend on transport, and abnormal NPC localization may disrupt gene expression since nups have roles in genome organization. (12/N)
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We hope this work provides a framework for future NPC studies in neurons & the tools will be adapted in future physiological and disease studies. Thanks to everyone who made this work possible, especially @VeatchLab and Sebastien Phan (NCMIR, UCSD) for collaborations! (13/13)
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