@BarmadaLab

Barmada lab @UMich. We study cellular mechanisms underlying ALS/FTD & RNA biology with focus on neurodegeneration. (group-run account)

 Ann Arbor, MI
barmadalab.com/
Joined May 2020
  • Tweets60
  • Following45
  • Followers383
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New preprint from our and @BillDauerNeuro labs, also with @pappassa! @suminkim28 characterized neuronal NPC biogenesis and implicates mislocalized/delayed NPC assembly in DYT1 dystonia. See tweetorial below ⬇️
Sumin Kim@suminkim2828 Apr 2023
Excited to share my thesis work! Using super-resolution microscopy and a new HaloTag-Nup107 mouse line, we find that 1) NPC biogenesis is upregulated during neuronal maturation and that 2) torsinA is essential for normal localization and assembly kinetics of neuronal NPCs. (1/N)
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Our work on matrin3 is now out on PNAS: pnas.org/doi/10.1073/pnas.22… Congratulations to all authors!

Neuronal activity regulates Matrin 3 abundance and function in a calcium-dependent manner through...

RNA-binding protein (RBP) dysfunction is a fundamental hallmark of amyotrophic lateral sclerosis (ALS) and related neuromuscular disorders. Abnorma...

pnas.org
Barmada Lab@BarmadaLab15 Apr 2022
Another preprint out from our lab! MATR3 abundance and RNA binding are regulated by neuronal activity, and pathological mutations disrupt activity mediated degradation of MATR3 via calpain1. This links activity dependent regulation of MATR3 and disease! biorxiv.org/content/10.1101/…

Neuronal activity regulates Matrin 3 levels and function in a calcium-dependent manner through...

RNA-binding protein (RBP) dysfunction is a fundamental hallmark of amyotrophic lateral sclerosis (ALS) and related neuromuscular disorders. Abnormal neuronal excitability is also a conserved feature...

biorxiv.org
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Just OUT: A fantastic commentary on our paper by @EmilePinarbasi & @BarmadaLab! @jclinicalinvest doi.org/10.1172/JCI168215 Thank you so much!
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Barmada Lab retweeted
mito911@mito911_11 Jan 2023
🎉NEW SPEAKER! 🗣️Dr. Sami Barmada @BarmadaLab 🗓️15th June '23, 11 am EST 📝us06web.zoom.us/webinar/regi…
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We have an opening for a postdoc! Come work with us on ALS/FTD ⬇️
This Post is from an account that no longer exists. Learn more
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Our story on m6A and TDP43 is now out in Molecular Cell! sciencedirect.com/science/ar…
Barmada Lab@BarmadaLab4 Apr 2022
Excited to share that our latest preprint is out! Here we show that m6A modulates TDP43 RNA binding and that RNAs are hypermethylated in ALS. We also found if you knockdown an m6A reader, YTHDF2, you can mitigate disease related toxicity!
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Also, Sami will be giving a talk on MTMR5 and neuronal autophagy at 4:53pm in the "Mechanisms of Autophagic and Endolysosomal Trafficking in Neuronal Function and Neurodegeneration" subgroup tomorrow! #CellBio2022
Barmada Lab@BarmadaLab4 Dec 2022
Check out our lab's posters at #CellBio2022 tomorrow (Monday Dec 5)! - Genesis Rodriguez on VPS13A function in mitochondria/ER (P2106/B430) - Josephine Wu on calcium and calmodulin-dependent Matrin3 homeostasis (P2076/B399) - Sumin Kim on neuronal NPC biogenesis (P2019/B339)
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Check out our lab's posters at #CellBio2022 tomorrow (Monday Dec 5)! - Genesis Rodriguez on VPS13A function in mitochondria/ER (P2106/B430) - Josephine Wu on calcium and calmodulin-dependent Matrin3 homeostasis (P2076/B399) - Sumin Kim on neuronal NPC biogenesis (P2019/B339)
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6 @UMich scientists & engineers have been named the 2022 winners of the #MBioFAR Award, which recognizes exceptional mid-career faculty in the biosciences. Congrats @BarmadaLab @fu_jianping @LyssiotisLab @AlisonNarayanUM, James Moon, Elizabeth Speliotes. news.umich.edu/six-u-m-resea…
Six U-M researchers receive Biosciences Initiative award for excellence among mid-career faculty

ALT Six U-M researchers receive Biosciences Initiative award for excellence among mid-career faculty

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Congratulations to @AlisonNarayanUM, who has been named a 2022 MBioFAR awardee! This #UMBiosciences award recognizes exceptional mid-career faculty in the biosciences and supports their continued pursuit of innovative, high-risk research. record.umich.edu/articles/si…
Photos of the six MBioFAR awardees. Top row, from left: Sami Barmada, Jianping Fu, Costas Lyssiotis. Bottom row, from left: James Moon, Alison Narayan, Elizabeth Speliotes.

ALT Photos of the six MBioFAR awardees. Top row, from left: Sami Barmada, Jianping Fu, Costas Lyssiotis. Bottom row, from left: James Moon, Alison Narayan, Elizabeth Speliotes.

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Congrats @SEWrightPhD!
Todd Lab @UM@realToddLab29 Jul 2022
Our newest paper is out! @SEWrightPhD and friends discovered that RAN translation of CGG repeats triggers translational frameshifts that create toxic aggregation-prone chimeric proteins! A quick 🧵1/5: #FragileX #ALS #dementia academic.oup.com/nar/advance…

CGG repeats trigger translational frameshifts that generate aggregation-prone chimeric proteins

Abstract. CGG repeat expansions in the FMR1 5’UTR cause the neurodegenerative disease Fragile X-associated tremor/ataxia syndrome (FXTAS). These repeats fo

academic.oup.com
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Congratulations to Mike on a fantastic thesis defense today! Mike’s work on m6A and TDP43 opened up many new avenues for the lab to pursue, and he has been pivotal in introducing the lab to science memes. Great job and many congratulations, Dr. McMillan!
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xitter.cf/barmadalab/status/1511…
Barmada Lab@BarmadaLab4 Apr 2022
Excited to share that our latest preprint is out! Here we show that m6A modulates TDP43 RNA binding and that RNAs are hypermethylated in ALS. We also found if you knockdown an m6A reader, YTHDF2, you can mitigate disease related toxicity!
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Nico Gomez from the @BarmadaLab is primarily interested in exploring how the regulation of nucleic acid, the primary bearer of durable biological information across all living things, can be used to understand and treat disorders of the brain. Read more: rna.umich.edu/faculty/featur…
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Barmada Lab retweeted
Maday Lab@MadayLab20 Jun 2022
Honored to highlight exciting work from @BarmadaLab elucidating mechanisms that regulate autophagy in neurons! sciencedirect.com/science/ar…
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Our most recent paper is out! We used iNeurons to identify MTMR5 as a regulator of neuronal autophagy. Our findings suggest a potential strategy to modulate autophagy in neurodegenerative disease. authors.elsevier.com/a/1f4vZ…
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This work was led by Jason, who recently started his own lab at Johns Hopkins. Check out his review on autophagy and ALS (pubmed.ncbi.nlm.nih.gov/3405…) and other works on his profile: tinyurl.com/yc84cds5!
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Barmada Lab retweeted
May Khanna
@may_khanna17 May 2022
Excited that this paper is out! Grp78/BiP/ HspA5 binds directly to TDP‑43 and mitigates toxicity associated with disease pathology A clever BioID to drive TDP-43 (not over-expressed) in cytoplasm and nucleus: which Hsp70 modulates TDP-43? rdcu.be/cNJCa 1/4
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Neuronal activity regulates Matrin 3 levels and function in a calcium-dependent manner through calpain cleavage and calmodulin binding biorxiv.org/cgi/content/shor… #bioRxiv
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Another preprint out from our lab! MATR3 abundance and RNA binding are regulated by neuronal activity, and pathological mutations disrupt activity mediated degradation of MATR3 via calpain1. This links activity dependent regulation of MATR3 and disease! biorxiv.org/content/10.1101/…

Neuronal activity regulates Matrin 3 levels and function in a calcium-dependent manner through...

RNA-binding protein (RBP) dysfunction is a fundamental hallmark of amyotrophic lateral sclerosis (ALS) and related neuromuscular disorders. Abnormal neuronal excitability is also a conserved feature...

biorxiv.org
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