@AydoganLabi
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We study principles of biological time control with a focus on the emerging concept of autonomous clocks. Columbia University & HHMI
New York, NY
Joined November 2019
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EXCITED to unroll this 🧵 on our new story on the metabolic licensing of animal development... How did we even get here..?
shorturl.at/vuCIh
Early embryo is thought of a pre-set machine that's set to go once it's fertilized - check out this gorgeous 📽️from Phil Keller!
Aydogan Lab retweeted
同じ遺伝子を2つ持っていても、脳は育ちきらない。
哺乳類の遺伝子には、父由来か母由来かで働き方が変わるものがある。ゲノムインプリンティング(刷り込み)と呼ばれ、ヒトとマウスでおよそ200個。ただし母のゲノムだけを持つ単為発生の胚は着床後まもなく死ぬため、その先で何が起きるかは長く手つかずのまま。
大阪大学と東邦大学の山口新平氏らが作ったのがCReP法。中脳と小脳を作れないWnt1欠損の胚を受け皿にし、そこへ単為発生由来の細胞を入れて脳を埋めさせる。脳の形は完全に戻った一方、体重は伸びず、多くは生後まもなく死亡。
その脳では、父由来でしか働かない遺伝子Dlk1が減り、細胞の運命を決めるNotchの信号が過剰に。神経細胞が減り、グリアへ偏っていた。老化研究がいま向き合っているのも配列ではなく印の側で、層としては地続き。
どの遺伝子を持つか、から、どちらから受け取ったか、へ。発生の読み方が一段深くなった。
※マウスの基礎研究で、ヒトへの外挿は未検証。培養系の検証は3〜4例規模。
出所:Scientific Reports(2026/6/8)Parthenogenote-derived brain unveils the critical role of paternal genome in neural development
nature.com/articles/s41598-0…
@SciReports
Go Garner Lab!!! Sincere congratulations to @rikkigarner!!!
Excited to announce that the Rikki Garner lab has opened its doors in beautiful Austin, TX! Our interdisciplinary lab @UTAustin @UT_MBS investigates tissue fluidity as a universal physical regulator of multicellular patterning in health and disease. rikkigarnerlab.org/ 1/n
Aydogan Lab retweeted
How are mitotic chromosomes built? 🏗️ Our Review @TrendsGenetics revisits the classical chromosome scaffold model and connects it to condensins, topoIIα, and physical forces. We propose interphase chromatin domains as “building blocks”🧩of chromosomes:
authors.elsevier.com/a/1nmwr…
Aydogan Lab retweeted
Can light build centrosome-like activity? 💡🔬 We introduce LISA (Light-Induced Spindle Assembly), @emboreports By clustering Aurora A with optogenetics, we control centrosome-like microtubule nucleation that rescues spindle defects after centrosome loss. shorturl.at/9h3VQ
Aydogan Lab retweeted
🚨 Excited to share our latest preprint on @bioRxiv!
We’ve developed a rapid & highly efficient method to generate human 8-cell-like cells (ri8CLCs) for modeling early human embryogenesis and ZGA.
📖 Read the full paper here: biorxiv.org/content/10.64898… 🧪👇
This is just SO good..!!!!
Nuclear pore complexes labelled for NUP96🟥 and Mab414🟦, imaged from confocal to high-power STED.
Each imaging mode reveals progressively finer structural details.
One sample, multiple imaging modes - with the #MIRAVAPolyscope.
#fluorescencefriday
Aydogan Lab retweeted
Incredibly happy to share the first publication from our lab, now published in Nature Cell Biology! 🎉
How do cells coordinate RNA processing with nuclear organization and the cell cycle?
nature.com/articles/s41556-0…
1/10
Can't wait to work together with our fantastic new colleague @begum_aydin_ on board @ColumbiaGenDev!
I'm thrilled to share that I'll join Columbia University in Jan 2027 as an Assistant Professor in @ColumbiaGenDev & @CSCIColumbia ! A long-held dream; I'm grateful for my mentors and colleagues.
We'll study microbiota-ENS interactions & we’re hiring!
theaydinlab.com/?ref=1
Aydogan Lab retweeted
A developing embryo repeatedly divides without growing, so each new cell inherits less room. Does the machinery of mitosis simply shrink with it?
New work in C. elegans embryos found a striking split. The mitotic spindle—the microtubule machine that organizes division—became shorter as cells became smaller. But the dynamics of chromosome separation remained largely unchanged.
Imaging, laser ablation, electron tomography, and modeling point to different physical modules: astral microtubules and cortical motors tune spindle elongation to cell size, while microtubules in the spindle midzone help preserve chromosome movement.
Development often preserves an outcome without preserving every dimension of the machinery. Robustness can come from letting different parts of a system follow different scaling rules.
Open-access paper: doi.org/10.1038/s41467-026-7…
Aydogan Lab retweeted
Happy to share the preprint of a brand new story from the group. It was started in 2019, stopped for pandemic and revived in 2025.
Subthreshold perturbation of DNA replication induces a secretory response and a bystander effect in naïve human fibroblasts biorxiv.org/content/10.64898…
Aydogan Lab retweeted
We are finally out at Cell Systems! Congrats Elizabeth Eck, @bmoretti_bio, Brandon Schlomann and our friends in the labs of @loicaroyer and @OatesLab!
sciencedirect.com/science/ar…
MS2 in zebrafish! Elizabeth Eck, @bmoretti_bio and Brandon Schlomann, in collaboration with @loicaroyer and @OatesLab labs, discovered that smooth protein oscillations in the segmentation clock are the result of discrete transcriptional pulses.
doi.org/10.1101/2024.01.03.5…
Aydogan Lab retweeted
Happy to share a new perspective on the mechanometabolic programming!
Much love to the literature which informs that perspective, and the co-authors!
sciencedirect.com/science/ar…
Aydogan Lab retweeted
Reconstructing ancient protein alphabets: what can we truly infer?
#genetics #proteins #evolution
sciencedirect.com/science/ar…
Aydogan Lab retweeted
Temporal changes in metabolism guide oligodendrocyte precursor cell dynamics in aging and multiple sclerosis cell.com/neuron/fulltext/S08…
Aydogan Lab retweeted
When tension increases the nucleus is compressed and escapes its keratin cage. New paper our in @NaturePhysics. Led by Tom Golde with theory by Marco Pensalfini and Marino Arroyo. nature.com/articles/s41567-0…
Aydogan Lab retweeted
I'm glad to share the publication of new work carried from my postdoc with @weaverbird45 to my new laboratory @sbpdiscovery!
Major implications for the relationship between immune oncology and metabolic syndrome.
I'm deeply grateful to my co-authors!
science.org/doi/10.1126/scia…
🧵Heartfelt congratulations to our lab’s first PhD student—and soon-to-be graduate—Andrew Alamban on receiving the 2026 ASCB | EMBO Porter Prize for Research Excellence!
👇In celebration of his work, here is a brief thread highlighting Andrew’s accomplishments in the lab!
Congratulations to the 2026 ASCB Honorific Award Winners!
This year's recipients are recognized for outstanding achievements in research, education, mentoring, leadership, and inclusion that continue to advance cell biology.
See the full list:
ascb.org/society-news/ascb-a…
Andrew’s first major contribution to our lab was his thoughtful role in developing our perspective on autonomous clocks, which outlined their shared and generalizable features.
elifesciences.org/articles/7…
Next, as a co-first author, Andrew helped discover that cytoplasmic divisions can operate autonomously from nuclei and CDK/Cyclins using Drosophila embryos.
sciencedirect.com/science/ar…
For now, check out Andrew’s latest contributions to our groups’s recent collaborative work with Paolo Rinaudo’s lab @UCSF, which begins to reveal—and experimentally test—key aspects of this quality-control logic during mammal preimplantation development.
biorxiv.org/content/10.64898…
If you are attending the ASCB | EMBO 2026 Meeting, be sure to catch Andrew’s presentation of all this exciting endeavor!
GO, @AndrewAlamban !!!!!