We seek to understand the molecular mechanisms that regulate genome organization and gene expression in time and space. Based in @MITdeptofBE
Cambridge, MA
Joined August 2019
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ASHansen Lab retweeted
Come on join us! We are searching for the next technical associate to join our lab ~Summer 2026.
This could be a great position for someone who is graduating this spring and is looking for 2 more years of research experience before starting their PhD:
careers.peopleclick.com/care…
We had a wonderful time celebrating together at our lab’s holiday party, enjoying good company, good food, and a very fun lab trivia. Grateful for a great year and an even better team!
ASHansen Lab retweeted
The @Anders_S_Hansen Lab find tiny loops in the genomes of dividing cells. Enabled by a new high-resolution mapping technique, the findings overturn a long-held belief that the genome loses its 3D structure when cells divide. @NatureSMB ow.ly/th0l50Xf782
ASHansen Lab retweeted
Jamie Drayton and I were fortunate to contribute RCMC to this beautiful paper from Eder, Moene...van Steensel that systematically maps the relationship between enhancer location and gene expression (and nice to see RCMC predict expression in Fig 2H-I): science.org/doi/10.1126/scie…
ASHansen Lab retweeted
Congratulations to Masahiro Nagano on his new paper on STAG3-cohesin.
STAG3-cohesin has a much shorter residence time which leads to altered 3D genome organization and STAG3-cohesin is important for male germ cell differentiation.
nature.com/articles/s41594-0…
ASHansen Lab retweeted
Who's up at BATS?
@VarshiniRam23 (@hansen_lab @Anders_S_Hansen): “3D Genomic Mapping Across Human Erythropoiesis” ow.ly/8NXO50WVNaB
ASHansen Lab retweeted
Congratulations to Dr. Viraat Goel and Dr. Domenic Narducci, both new PhDs in Biological Engineering from the lab!
ASHansen Lab retweeted
(1/13) Thread on @mazzocca_matteo @DomenicNarducci @SGrosseHolz @_jessematthias new preprint
Q: how does chromatin move?
Using MINFLUX, SPT & SRLCI, we track chromatin dynamics across 7 orders of magnitude in time to provide some answers
biorxiv.org/content/10.1101/…
ASHansen Lab retweeted
(1/n) New preprint from @claricehongky Fan Fang @VarshiniRam23 in collab w Jie Liu
Q: How do we get ultra-high-res 3D genome maps?
A: New deep learning model, Cleopatra.
Cleo trains on Micro-C, fine-tunes on RCMC, and predicts genome-wide 3D maps
biorxiv.org/content/10.1101/…
Excited to share my first preprint from @hansen_lab! It's got genomics, AI, and biology - all wrapped up in a great paper. Also very grateful to my amazing collaborator, Fan, for all his hard work. Please check it out and let me know what you think!
tinyurl.com/bdfvtd6f
ASHansen Lab retweeted
Check out Masahiro Nagano's preview sciencedirect.com/science/ar… of a very cool paper from Tjalsma...Wouter de Laat: cell.com/cell-genomics/fullt…
Distance matters: How protein regulators facilitate enhancer-promoter interactions and transcription dlvr.it/TJWy4b
ASHansen Lab retweeted
Mostly on BlåSky but excited to share James Jusuf's preprint:
By integrating Micro-C with SuperRes Live-Imaging we perform absolute quantification of looping (e.g. this loop is present 3%).
We quantify mESC 36k loops: <loops> are generally rare (2.3%).
biorxiv.org/content/10.1101/…
ASHansen Lab retweeted
Our preprint by @DomenicNarducci and the companion preprint by @deWitLab are now out in @MolecularCell
ZNF143 is not a general looping factor and was identified as such due to a non-specific antibody. Instead it is TF with the longest residence time measured (to our knowledge)
(1/14) Excited to share our new work on ZNF143/ZFP143 by @DomenicNarducci
ZNF143 has been widely reported to be a general loop factor
Instead we and @deWitLab in a companion preprint show that ZNF143 is a TF with no loop function:
biorxiv.org/content/10.1101/…
biorxiv.org/content/10.1101/…
ASHansen Lab retweeted
Very grateful to @NIH_CommonFund for funding our Transformative Research Award #NIHHighRisk
#NIHHighRisk Transformative Award recipient Dr. Anders Hansen of @MITdeptofBE will be exploring how transcription factors find their target cites in synthetic and #CancerBiology
Congrats to @ViraatGoel James Jusuf et al. on new preprint in collab with @Irate_Physicist @blobelgroup @leonidmirny discovering transient microcompartments that connect enhancers and promoters in mitotic chromosomes: biorxiv.org/content/10.1101/…
(1/n) From @ViraatGoel @Irate_Physicist et al. collab w @blobelgroup @leonidmirny biorxiv.org/content/10.1101/…
RCMC at the M-to-G1 transition reveals strong microcompartments between CREs (E,P) in mitosis, that weaken upon G1 entry
Sims reveal chromosome compaction as key regulator
Come and see James' BATS talk today
First BATS of the academic year 2024/25 🥳!
James Jusuf (@hansen_lab): “Genome-Wide Absolute Quantification of Chromatin Looping”
ow.ly/Coyb50ThrOE
ASHansen Lab retweeted
Congrats to @GavinSchlissel @Pulin_Li with single-molecule imaging contribution from @DomenicNarducci @hansen_lab
Single-molecule imaging of hedgehog in morphogen gradients reveals a surprisingly complex diffusion mechanism: pnas.org/doi/10.1073/pnas.24…
ASHansen Lab retweeted
Congrats to @ngaboreden @blobelgroup with RCMC contribution from @ViraatGoel @hansen_lab .
Having recently worked on what we thought was a looping factor (ZNF143 biorxiv.org/content/10.1101/… ) it was amazing to work on a strong Enh-Promoter looping factor LDB1 biorxiv.org/content/10.1101/…
Happy to share my thesis work, now online at bioRxiv. We show that LDB1 organizes Enhancer-Promoter interaction networks and can function independently of cohesin!
biorxiv.org/content/10.1101/…