Postdoctoral Research Fellow. Functional Genomics, DAGS@ Merck | PhD. in Experimental Medicine@ McGill| CRISPR-based Spatial Genomics
Massachusetts, USA
Joined March 2012
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Edgar Pinedo-Carpio retweeted
Free scientific illustrations for biologists! 😍
@NIH has released a library of 500+ free scientific illustrations to create figures, presentations, and illustrations!
all freely available in the public domain.
Retweet and spread the message!
bioart.niaid.nih.gov/
Edgar Pinedo-Carpio retweeted
FANCI that! New #LMSResearch from @RuedaLab has solved the decades long mystery of how DNA damage by sunlight, alcohol and pollution is identified so it can be repaired.
This discovery opens up opportunities for improved cancer treatments.
lms.mrc.ac.uk/fanci-that-dec…
Edgar Pinedo-Carpio retweeted
Excited to launch our cloud-based image analysis platform today at nimbusimage.org! Analyze and interact with your data, all in the browser. Follow sign-up instructions to request an account.
Edgar Pinedo-Carpio retweeted
How did humans loose our tails?
~25 million years ago, a monkey in Africa had a random mutation due to transposable elements (TEs) - pieces of DNA that can copy themselves in the human genome.
An Alu element was inserted into the intron of the TBXT gene, producing alternative transcripts lacking the 6th exon. This is due to pairing with another Alu element in the other side of the 6th exon.
This mutation is only observed in hominoids without tails: gibbons, gorilla, chimps. Their common ancestors can be traced to that one monkey-like animal 25 million years ago.
Introducing this mutation to mouse results in complete loss of the tail.
Congrats @ItaiYanai
Read this week's cover story of Nature.
nature.com/articles/s41586-0…
Edgar Pinedo-Carpio retweeted
Only one team could progress to the next round... 🇯🇵🇸🇳
#BeachSoccerWC
Edgar Pinedo-Carpio retweeted
We are thrilled to share our study on the role of cellular #senescence in #diabetic macular edema and clinical data for the first #senolytic developed for the eye . Congrats @SerCresGar and @UnityBiotech!
@UMontreal @NatureMedicine @CellSenResearch
nature.com/articles/s41591-0…
Edgar Pinedo-Carpio retweeted
Excited to share our recent study in @CellCellPress led by @GiuseppeLeuzzi_ on the dual role of the DNA translocase SMARCAL1 in regulating innate immune signaling and the expression of the PD-L1 immune checkpoint factor! authors.elsevier.com/a/1iWe5…
Edgar Pinedo-Carpio retweeted
On a scale of 1-10, 10 being perfect, I have to award this eagle with a 12. 😃 If you ever wanted to see a perfect example of an eagle’s ability to fly, grab a fish and eat it in mid air, I think this is it. What would you give this eagle on a scale of 1-10?
Edgar Pinedo-Carpio retweeted
Excited to share: "CRISPRmap: Sequencing-free optical pooled screens mapping multi-omic phenotypes in cells and tissue". We applied our novel approach in wonderful collaborations with @CicciaAlberto, @DrEdmondChan, @elhamazizi, and @landau_lab. biorxiv.org/content/10.1101/…
Edgar Pinedo-Carpio retweeted
I was watching Lord of the Rings last night and realized there are many parallels with academia!
A thread 🧵👇
Edgar Pinedo-Carpio retweeted
Wow. Wow. Wow.
Incredible powerful message (incredible speech writing)—to those who stumbled on the wrong path and may ruin their future for not knowing the past.
The weight of history
Edgar Pinedo-Carpio retweeted
Immensely proud to share our four papers on #SingleCell dissection of #Alzheimers Disease coming out in @CellCellPress today, reporting 2.3M #scRNA profiles and 850k #scATAC profiles across 427 post-mortem human brain samples from AD and non-AD donors in a wonderful #interdisciplinary collaboration with @DrLiHueiTsai between @MIT @MIT_Picower @MIT_CSAIL @BroadInstitute @RushUniversity
Paper 1: scRNA + vulnerability + resilience cell.com/cell/fulltext/S0092…
Paper 2: scATAC + GWAS + Epigenome Erosion cell.com/cell/fulltext/S0092…
Paper 3: Microglia States + reprogramming cell.com/cell/fulltext/S0092…
Paper 4: DNA damage + gene fusions cell.com/cell/fulltext/S0092…
MIT News: news.mit.edu/2023/decoding-c…
Issue: cell.com/cell/current
News & Views: cell.com/cell/fulltext/S0092…
Edgar Pinedo-Carpio retweeted
Genes associated with autism and other neurodevelopmental disorders are identified using CRISPR screening in human forebrain assembloids. #NBThighlight
nature.com/articles/s41586-0…
Edgar Pinedo-Carpio retweeted
Svetlana Mojsov helped discover the hormone GLP-1, which led to the development of blockbuster obesity drugs. Now, she’s fighting for recognition. #LongReads scim.ag/45z @NewsfromScience
Edgar Pinedo-Carpio retweeted
We are very excited to share with you the results of great teamwork with @AmelieFT lab! In this study, two graduate students @lymphocytePC and @DessaptJcharacterized the critical role of FIRRM/C1orf112 in the disassembly of RAD51 during DNA repair. science.org/doi/full/10.1126…
Edgar Pinedo-Carpio retweeted
Today we report in @ScienceMagazine a one-time base editing treatment for Spinal Muscular Atrophy (SMA), the leading genetic cause of infant mortality worldwide, affecting ~1 in 10,000 births. science.org/doi/10.1126/scie…
PDF: drive.google.com/file/d/1H1k…
1/17
Edgar Pinedo-Carpio retweeted
Need an up-to-date #TreeofLife for teaching/conferences/wall paper? Talented PhD student @BasileBeaud drew a schematic consensus ToL from the most recently published phylogenies. Hope this is useful! Downloadable version in the thread👇
Edgar Pinedo-Carpio retweeted
Congratulations to Edgar for his successful PhD defense! Now we can all officially call him Dr. Pinedo-Carpio @lymphocytePC 👏👏👏 #phd #graduation #goodjob
Edgar Pinedo-Carpio retweeted
Ever wonder what’s happening at centromeres in resting cells? Our latest study, led by @xssaayman and in collab with @nussenza, demonstrates striking enrichment of DNA breaks at centromeres in quiescent human cells. Excited to share this work @MolecularCell now!
Online Now: Centromeres as universal hotspots of DNA breakage, driving RAD51-mediated recombination during quiescence dlvr.it/ShRC9b
Edgar Pinedo-Carpio retweeted
Delighted to share the exceptional work of post-doctoral fellow Mathieu Neault in close collaboration with @MelicharLab @johannes_zuber Tim Shaw, Tanja Gruber @LauraHulea and many others! Thanks to colefoundation.ca @CIHR_IRSC @CCSResearch biorxiv.org/content/10.1101/…