Willem Vanderlinden retweeted
Can we design proteins that cut other proteins? Our de novo cysteine protease paper is out in Nature! We designed new folds that cleave peptide backbones, with activity demonstrated in mammalian cells. Paper and code 👇
nature.com/articles/s41586-0…
Willem Vanderlinden retweeted
I’m sorry you’re dealing with this. But when a university taking in billions in revenue chooses not to buffer even short-term funding delays or prioritize its resources around science, while administrators expand their offices and take in seven-figure salaries, it says everything about the model. Scientists are treated less as scholars to be supported and more as revenue generators for indirect costs, with all the financial risk pushed onto them.
Willem Vanderlinden retweeted
NEW: Dynamic allostery in DNA confirmed! IDR of a transcription factor controls DNA allostery! Single-molecule FRET, cryo-EM, molecular simulations, and elastic network models. Thanks to all co-authors for the amazing team effort!
biorxiv.org/cgi/content/shor…
Willem Vanderlinden retweeted
Nature research paper: Integrase anchors viral RNA to the HIV-1 capsid interior
go.nature.com/3OlBgUU
Willem Vanderlinden retweeted
Today, we introduce a nomenclature that can express discrete PTMs, proteoforms, nucleoforms, or situations where defined PTMs exist in an uncertain context and can describe how proteoforms are configured in functionally distinct complexes across biology. authors.elsevier.com/c/1lt5I…
ALT Today, we introduce a nomenclature that can express discrete PTMs, proteoforms, nucleoforms, or situations where defined PTMs exist in an uncertain context. Though specifically designed for the chromatin field, adaptions of the framework could be used to describe—and thus dissect—how proteoforms are configured in functionally distinct complexes across biology. Thank you to the many co-authors for your input and support. https://authors.elsevier.com/c/1lt5I3vVUPVb4c
Willem Vanderlinden retweeted
It has taken a lot of work and a long journey, at the end we show that there is a colloidal way amino acids stabilize proteins. A great collaboration with Alfredo Alexander-Katz that proposes new theory on colloidal stability. Just published in @Nature rdcu.be/eFrqm
Willem Vanderlinden retweeted
1/4 📢🥳now online: BROWNIAN DNA COMPUTING - Unlike fuel-driven molecular computing with high-energy barriers, it exploits thermal fluctuations.
Inputs rectify state access, enabling fast, low-energy computation. 📜More in our preprint: biorxiv.org/content/10.1101/…
Willem Vanderlinden retweeted
How do chromatin remodelers use #IDRs to find their TF binding partners? Check out San’s tweetorial about SWI/SNF (cBAF) subunit ARID1A and β-catenin, now online at Mol Cell
Excited to share our new Molecular Cell paper! We show that β-catenin is an adaptor that links canonical BAF (cBAF) with binding partners via IDR-domain interactions. (1/7)
cell.com/molecular-cell/full…
Willem Vanderlinden retweeted
Excited to share our latest preprint biorxiv.org/content/10.1101/… @Alba_Edinburgh @AnjithaGireesh @SBSatEd @GeneCenter_LMU
Willem Vanderlinden retweeted
My lab has postdoc openings in the following areas: 1) Structural biology and single molecule biophysics; 2) Developing novel genome editing methods; and 3) Protein and RNA engineering. Please share the info with your trainees, and RT please. 🙏
postdocs.yale.edu/yale-postd…
Willem Vanderlinden retweeted
Come visit us in Edinburgh for this great conference.
Final announcement! #FragileNucleosome is honoured to be collaborating with the upcoming conference:𝐇𝐢𝐝𝐝𝐞𝐧 𝐂𝐞𝐥𝐥, 𝐃𝐚𝐫𝐤 𝐆𝐞𝐧𝐨𝐦𝐞. @chrstn_e , one of our organizers, will give a special lecture. Hope to see FN community there too! #hcdg25
tinyurl.com/37x72s67
Willem Vanderlinden retweeted
🚨🚨Please RT! 📢📢
Still time to submit short talk abstract for EdinPBS2025!
Five themes this year:
· Mechanobiology
· Protein pattern formation
· 4D Genome
· Stochastic biology
· Biohydrodynamics
bit.ly/EdinPBS2025
Willem Vanderlinden retweeted
Our story on the mechanism of co-transcriptional histone mark deposition is now officially out: science.org/doi/10.1126/scie…
Willem Vanderlinden retweeted
A great line-up of speakers at next week's 24th meeting of the Edinburgh Chromatin, Epigenetics and Transcriptional Regulation Network
Willem Vanderlinden retweeted
📢New paper alert!! With @boothbylab @alexholehouse @fried_lab we take a look at how an entire proteome survives desiccation. TLDR: Desiccation tolerance is encoded in specific residues on the protein surface, and occurs primarily in biosynthetic enzymes. shorturl.at/U5VS1
Willem Vanderlinden retweeted
Super excited to share our latest work looking at mechanisms that contribute to local hexatic and nematic ordering in tissue monolayers!
Intercellular friction and motility drive orientational order in cell monolayers | PNAS pnas.org/doi/10.1073/pnas.23…
Willem Vanderlinden retweeted
Our paper on how post-translational modifications modulate nucleosome-nucleosome interactions and conformational landscapes is out in @JMolBiol!
doi.org/10.1016/j.jmb.2024.1…
Congratulations Yi-Yun et al! Work at
@LMU_Muenchen
@CeNS_LMU
@UniUtrecht
@UUBeta @EdinburghUni
.
Willem Vanderlinden retweeted
Excited about the to-the-point and insightful perspective on our coarse-grained DNA-protein modelling and classification work by @petr_sulc in @BiophysJ doi.org/10.1016/j.bpj.2024.0…
Willem Vanderlinden retweeted
Check out our work on modelling protein-mediated DNA compaction/condensation at a coarse-grained level and on classifying the resulting complexes, just out in @BiophysJ
doi.org/10.1016/j.bpj.2024.0…
@LMU_Muenchen @CeNS_LMU @UniUtrecht @EdinburghUni
Willem Vanderlinden retweeted
Obituary: Roeland Nolte 1944-2024. I wrote this with Bert Meijer about our dear friend. Quoting Hávamál (Viking text): I know one thing which never dies: the reputation of each man. Roeland´s good reputation will certainly live forever. @NatureNano see:
rdcu.be/dDcT0
ALT Roeland Nolte (1944-2024). Photo courtesy of Johan Hoogboom.