@JPLab_

Chromosome Segregation @ Wellcome Centre for Cell Biology @WTcell, Univ of Edinburgh, UK @GeneCenter_LMU, Munich, Germany

 Edinburgh & Munich
jeyaprakash.bio.ed.ac.uk
Joined April 2019
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5Media
Fantastic collaboration @CarrollDonal indeed - our structures reveal how HSP90α/β keeps PIWI proteins in an open conformation, with surface exposed RNA binding domains, ready for RNA loading.
Donal O'Carroll@CarrollDonalJul 6
An amazing collaboration with @JPLab_. See our apo-PIWI-HSP90α/β structures: biorxiv.org/content/10.64898…

The structure of the apo-PIWI HSP90 complex

PIWI proteins are members of the Argonaute family and together with piRNAs protect metazoan germlines from transposons. PIWI proteins adopt a bi-lobed architecture with a central RNA-binding channel....

biorxiv.org
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Thank you all for an incredible 4 days at #IYM2025! 🙌 70+groups, 50+talks, 100+posters & 25+awards truly inspiring. Huge thanks to our amazing volunteers for making everything run flawlessly and keeping the science vibrant. Signing off from Bengaluru See you in 2027 (Kolkata)!
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Excited to share our latest preprint biorxiv.org/content/10.1101/… @Alba_Edinburgh @AnjithaGireesh @SBSatEd @GeneCenter_LMU

Chromatin Protection by the Chromosomal Passenger Complex

The chromosomal passenger complex (CPC; Borealin-Survivin-INCENP-Aurora B kinase) ensures accurate chromosome segregation by orchestrating sister chromatid cohesion, error-correction of kinetochore...

biorxiv.org
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Many thanks to Ryu-Suke Nozawa, Toru Hirota, Lea Dury, Willem Vanderlinden, Christos Spanos, @PaulaSoteloP @likhodeeva_m @mdrwilson @hopfnerlab for their valuable contribution!
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H4.V is Oryza-specific. It is a gatekeeper to promote deposition of active H4K5Ac during salt stress, a common stress for semi-aquatic rice. Big thanks to @JPLab_ @jp_arulanandam for beautiful CryoEM structures, Fred Berger @gmivienna for discussions, Vinoth Lab @NCBS for biochem
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Pleased to share that our CENP-32 story is now published! ⁦@JPLab_⁩ , Jun Liao, Erica Davis and Bill Earnshaw labs and several clinicians. Led by Avinash Dharmadhikari (CHLA, UCLA), @Alba_Edinburgh and Sheraz Khan. @SBSatEd ⁦@GeneCenter_LMU⁩ nature.com/articles/s41467-0…

RNA methyltransferase SPOUT1/CENP-32 links mitotic spindle organization with the neurodevelopmental...

Nature Communications - The RNA methyltransferase activity of SPOUT1/CENP-32 is crucial for accurate mitotic spindle organization. Here, the authors describe a neurodevelopmental disorder caused by...

nature.com
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Excited about #Fungal pathogens and the interplay with the host? Fully funded PhD in our lab @EdinUni_IRR @zje_institute @edin_EID. Excellent team, including @JPLab_ @ewjwallace and teaching in China! Deadline 31st January. Please RT! biomedical-sciences.ed.ac.uk…
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Exciting news! 🎉 After a long journey, my postdoctoral research is finally published! 🌟 While we often hear about telomere depletion with age, have you ever wondered what happens to our centromeres? 🤔 In this study, we show how centromeres weaken and ways to reactivate it !!
Molecular Cell@MolecularCell13 Jan 2025
Online Now: Centromere inactivation during aging can be rescued in human cells dlvr.it/THKs3M
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In our latest #PLOSGenetics paper, @SatyaDev2064 and coauthors report that the dependence of shugoshin on Bub1-kinase activity is dispensable for the maintenance of spin ... dx.plos.org/10.1371/journal.… @jncasr @bose_institute @IndiaDST @EdinburghUni @KaustuvSanyal

The dependence of shugoshin on Bub1-kinase activity is dispensable for the maintenance of spindle...

Author summary Precise segregation of the genome to daughter cells is the key to cell growth, survival, and proliferation. A proper attachment of spindle microtubules to the kinetochore of each...

journals.plos.org
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Join us in Stresa, Italy for the amazing @embo Chromosome Segregation and Aneuploidy organized by ⁦@SteSantaguida⁩ ⁦@ELogarinho⁩ ⁦@BenDavidLab⁩ ⁦@Foijer_lab⁩ ⁦@McclellandLab⁩ and myself. Registrations are open now! meetings.embo.org/event/25-a…
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Check out our latest structural paper about human OGG1 processing DNA lesions within nucleosome core particles, in collaboration with Chuanzheng Zhou's lab. #DNArepair #cryoEM nature.com/articles/s41467-0…

Structural basis for human OGG1 processing 8-oxodGuo within nucleosome core particles

Nature Communications - How DNA glycosylases repair base lesions within nucleosomes remains unclear. Here, the authors determine the cryo-EM structure of 8-oxoguanine-DNA glycosylase 1 bound to an...

nature.com
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Get in touch if you are interested in joining us in Galway!
Centre for Chromosome Biology@CCB_Galway19 Sep 2024
The CCB is looking for candidates to apply for independent fellowships to join us here in beautiful Galway. If you are interested please reach out! nature.com/naturecareers/job…

Group Leader - Galway (County), Connacht (IE)

The Centre for Chromosome Biology is seeking excellent candidates to be sponsored for establishing an an independent externally-funded research group

nature.com
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When kids are shrunk (remember Honey I Shrunk the Kids) or cells are tiny, use the power of Expansion Microscopy. This is what @Reza_Hashim21 et al. from @KaustuvSanyal lab @jncasr did in collab. with @Dey_Gautam lab @embl. Hashim explains how U-ExM expands fungal pathogens!
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#Chromosomes in early prometaphase are longer, have a more granular surface, and lack a primary constriction. From Cisneros-Soberanis, Simpson, Earnshaw et al. @WTcell: hubs.la/Q02Mx5G40 #StructuralBiology #Mitosis #CellDivision
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Excited to share our work showing how PLK1 licenses CENP-A deposition at centromeres to ensure centromere inheritance @WTcell @GeneCenter_LMU @SBSatEd @LMU_Muenchen @Pragya_Sriv @bethan_medina @Alba_Edinburgh @PaulaSoteloP @ERC_Research @wellcome & MRC science.org/doi/10.1126/scie…

PLK1-mediated phosphorylation cascade activates Mis18 complex to ensure centromere inheritance

Accurate chromosome segregation requires the attachment of microtubules to centromeres, epigenetically defined by the enrichment of CENP-A nucleosomes. During DNA replication, CENP-A nucleosomes...

science.org
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Also check out a parallel study with similar findings from the Musacchio lab @AndreaMusacchi1 @MusacchioLab @DuccioConti science.org/doi/10.1126/scie…

Role of protein kinase PLK1 in the epigenetic maintenance of centromeres

The centromere, a chromosome locus defined by the histone H3–like protein centromeric protein A (CENP-A), promotes assembly of the kinetochore to bind microtubules during cell division. Centromere...

science.org
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Thrilled to share our new paper in @ScienceMagazine, in which we identify p62/SQSTM1 as a critical regulator of micronuclei 🧬🔬🧫 #ScienceResearch science.org/doi/10.1126/scie…

A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements

Chromosomal instability (CIN) generates micronuclei—aberrant extranuclear structures that catalyze the acquisition of complex chromosomal rearrangements present in cancer. Micronuclei are character...

science.org
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Now online. ⁩ Distinct roles of spindle checkpoint proteins in meiosis - ScienceDirect With some updates from the preprint. Congratulations ⁦⁦@Anu_Mukherjee96 and as always thanks for Christos Spanos for his proteomics expertise. sciencedirect.com/science/ar…
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Excited to reveal our new chemical-genetic system to inhibit PP2A-B56 phosphatase. We use this to characterise its substrates and roles during mitosis. This is a simple yet powerful approach to inhibit any enzyme/protein relying on SLiM-based interactions biorxiv.org/content/10.1101/…

A chemical-genetic system to rapidly inhibit the PP2A-B56 phosphatase

Serine-threonine phosphatases have been challenging to study because of the lack of specific inhibitors. Their catalytic domains are druggable, but these are shared or very similar between individual...

biorxiv.org
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Two postdoctoral positions available in my group to investigate centromere structure, function and evolution - please get in touch if you are interested! jobs.cam.ac.uk/job/47525/ jobs.cam.ac.uk/job/47569/
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