@BiophysJ

Biophysical Journal, the premier journal of quantitative biology and leading journal for molecular, cellular, and systems biophysics research.

 Rockville, MD
biophysj.org
Joined August 2015
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71Media
#OPENACCESS: Different actions of RyR2 open and closed channel block explained by a multiscale Ca2+ release model. Derek R. Laver, James Welsh, Morris Vysma, and Bjorn C. Knollmann. buff.ly/ChjbT3u

Different actions of RyR2 open and closed channel block explained by a multiscale Ca2+ release model

RyR2 channels regulate Ca2+ release from the sarcoplasmic reticulum (SR), the Ca storage organelle in cardiac muscle. Altered RyR2 activity is a key factor promoting atrial and ventricular Ca-arrhy...

cell.com
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#OPENACCESS: Protein function-conditioned language models for variant effect prediction and controllable design. Shaowen Zhu, Yue Cao, Yihong Yang, and Yang Shen. buff.ly/Efn95HG

Protein function-conditioned language models for variant effect prediction and controllable design

Protein function-conditioned generative modeling can unify two core goals in protein engineering: predicting the effects of sequence variants and designing new sequences that satisfy functional...

cell.com
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Special issue call for papers: Biophysics of Membrane Reactions in the Brain. buff.ly/dhLFOVO
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Though driven by capillary forces, theory shows that the underlying physics of a droplet shape recovery and droplet fusion are different, helping interpret rheological properties of biomolecular condensates. buff.ly/s8irK9l
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#OPENACCESS: Proteome-wide structural and interaction analysis using cross-linking mass spectrometry and its applications. Shenbaga Moorthy Balakrishnan, Hifzur Rahman Ansari, and Taoufik Nedjadi. buff.ly/ovoTRNs

Proteome-wide structural and interaction analysis using cross-linking mass spectrometry and its...

Deciphering the mechanisms of protein-protein interactions (PPIs) and protein structural changes within the native cellular environment is crucial for advancing drug discovery. In vivo chemical...

cell.com
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Special issue call for papers: Single-Molecule Approaches to Reveal Structural and Mechanistic Properties of the Genome.buff.ly/Ify9mW4
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Special issue call for papers: Fifty Years of Protein Dynamics: Celebrating Andy McCammon and the Evolution of Computational Biophysics. buff.ly/JcBPrrO
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#OPENACCESS: Beiter et al. use coarse-grained MD simulations to understand how different endophilin subdomains interact with model membranes, revealing how the NBAR domain is recruited to and generates membrane regions with negative Gaussian curvature. buff.ly/KoiILF0

Subdomains of endophilin can drive membrane remodeling and facilitate controlled membrane scission

The NBAR-domain-containing protein endophilin, a major player in many endocytic pathways, has offered considerable insight into Bin/amphiphysin/Rvs (BAR)-domain-driven membrane remodeling. However,...

cell.com
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#OPENACCESS: Reimagining computational macromolecular modeling: AI-driven approaches. E. Sila Ozdemir, Hyunbum Jang, Ruth Nussinov, Ozlem Keskin, and Attila Gursoy. buff.ly/OeRHLLq
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Special issue call for papers: Genome Organization: Integrating Mathematics, Physics, and Computation for Advances in Biology and Medicine. buff.ly/yn4iIpe
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Special issue call for papers: The Past, Present, and Future of Muscle Biophysics. buff.ly/LDBUW2Z
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#OPENACCESS: A computational model simulates the complex process of skin wound healing by linking genetic circuits to tissue mechanics—a step forward for improving wound therapies. buff.ly/0KDRwnE

Spatio-temporal multiscale cell modeling of skin wound healing

Human skin wound healing is a complex process of tissue pattern formation driven by massive cell migration and regeneration, coordinated through intercellular communication. A multiscale tissue...

cell.com
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Give cells different “road markings” and they change how they travel! Zhao et al. explore how 2D adhesion patterns reshape cell morphology and guide migration—showing how the cellular landscape influences movement. buff.ly/5tTIHqL
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Special issue call for papers: Stephen H. White: In Memoriam. buff.ly/LF0EYZp
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Special issue call for papers: Fazly Ataullakhanov: In Memoriam. buff.ly/U2LwrXc
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#OPENACCESS: Condensates and cell states: A new paradigm for understanding tumor biology. Ruth Nussinov and Hyunbum Jang. buff.ly/yGr4IZT

Condensates and cell states: A new paradigm for understanding tumor biology

Traditionally, cells have been classified by their type. Identifying cell types was deemed vital for understanding their biological processes. More recently, cell-type classification has been...

cell.com
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Revealing a role for the bacterial flagellar hook in torque transmission. Das et al. show that the asymmetric torque–speed relationship of the bacterial flagellar motor arises from the rotation-dependent elasticity of the hook and not the motor itself. buff.ly/qC5hl4d
🤖 Made with AI

Hook stiffness as a mechanical switch for torque regulation in the bacterial flagellar motor

The bacterial flagellar motor drives cell motility by rotating the flagellar filament and converting ion flux into mechanical work. At low counterclockwise (CCW) rotational speeds, the motor operates...

cell.com
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Special issue call for papers: Physical Properties of Cells: From Measurement to Medicine, A Tribute to Jochen Guck. buff.ly/9S2GAQl
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Read about the cover art for the newly released issue of Biophysical Journal on the BPS Blog: buff.ly/mDTAsBN

Similar Structure, Different Dynamics: The Melbournevirus Nucleosome-Like Particle

Histones provide one of biology’s most familiar solutions to the problem of organizing DNA. In eukaryotes, DNA wraps around histone proteins to form nucleosomes, creating the basic...

biophysics.org
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Biophysical Journal thanks all the reviewers and editors who make our journal possible during #PeerReviewWeek! See all events taking place at peerreviewweek.net/. #PRW2026 @PeerRevWeek

Peer Review Week (PRW) is a global celebration of the vital role peer review plays in ensuring the...

Peer Review Week (PRW) is a global celebration of the vital role peer review plays in ensuring the quality and integrity of research.

peerreviewweek.net
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