@StadtmuellerLab

Assistant Professor of Biochemistry @Illinois_Alma | @ILLINOISmed | @MCB_Illinois | Mother | Structural Biologist | Love antibodies |

 Urbana, IL
stadtmuellerlab.org/
Joined January 2021
  • Tweets71
  • Following264
  • Followers209
9Media
A mucosal #antibody called #SIgA can bind to bacterial surface proteins, triggering an immune response to improve infection outcomes. But these interactions are poorly understood.
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Beth Stadtmueller retweeted
Genomic Biology@IGBIllinois5 Dec 2023
Although the role of antibodies is universal, the structure varies in different animals. In a new study, researchers analyzed the antibody Immunoglobulin M in rainbow trout to shed some light on why these proteins have evolved over time. Learn more at bit.ly/3uOVbBW.
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Happy to share our labs new publication detailing the structure of IgM from fish. Great work by graduate student Mengfan (Iris) Lyu and @DrAndreyM! #IgM #CryoEM nature.com/articles/s41467-0…
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Happy to share the latest preprint from the @StadtmuellerLab - an incredible effort by recent PhD student @Sonya31397350! Engineered Secretory Immunoglobulin A provides insights on antibody-based effector mechanisms targeting Clostridiodes difficile biorxiv.org/content/10.1101/…

Engineered Secretory Immunoglobulin A provides insights on antibody-based effector mechanisms...

Secretory (S) Immunoglobin (Ig) A is the predominant mucosal antibody, which mediates host interactions with commensal and pathogenic microbes, including Clostridioides difficile . SIgA adopts a...

biorxiv.org
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Thrilled to announce that Stadtmueller Lab graduate student @Sonya31397350 is now Dr. Sonya Kumar Bharathkar!!! Congrats Dr. Sonya!!! #antibodies #IgA
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Happy to share recent work from the @StadtmuellerLab published today in Nature Communications! Great effort by recent graduate Qianqiao (Heather Liu)! #IgA #antibodies #CryoEM nature.com/articles/s41467-0…

SIgA structures bound to Streptococcus pyogenes M4 and human CD89 provide insights into host-path...

Nature Communications - Here, the authors used cryo-EM to explore secretory Immunoglobulin A interactions with bacterial and host receptors, uncovering unexpected binding stoichiometry and...

nature.com
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Thrilled to introduce Dr. Qianqiao (Heather) Liu, the first PhD graduate from the Stadtmueller Lab! Congrats Heather!!! We wish you well on your next adventure in the @the_sharaf_lab @Stanford !
So many ways to represent an SIgA structure!

ALT So many ways to represent an SIgA structure!

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Beth Stadtmueller retweeted
Edward T Eng@edward_eng28 Sep 2023
@StadtmuellerLab & Qianqiao (Heather) Liu shared how cryoEM training & access at NIH sponsored national centers helped investigate polymeric antibodies. The talk will be posted soon at youtube.com/c/CryoEMServiceC… Access #cryoEM resources at no cost: cryoemcenters.org/
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Happy to share our new review with @Slack1Emma and @AM_Hockenberry ! annualreviews.org/eprint/MWT…
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Beth Stadtmueller retweeted
Lacra Bintu@BintuLacra16 May 2023
Our new manuscript, in collaboration with the Bassik Lab, is out on bioRxiv. After much screening, new CRISPRi (better KRAB) and especially better CRISPRa=dCas9-NFZ (with an ancient KRAB!): biorxiv.org/content/10.1101/…

Development of compact transcriptional effectors using high-throughput measurements in diverse...

Human nuclear proteins contain >1000 transcriptional effector domains that can activate or repress transcription of target genes. We lack a systematic understanding of which effector domains regulate...

biorxiv.org
Josh Tycko@JoshTycko15 May 2023
New preprint! 🗞️ We used pooled protein screens to develop compact human transcriptional effectors that work across diverse biological contexts to activate or silence gene expression biorxiv.org/content/10.1101/…

Development of compact transcriptional effectors using high-throughput measurements in diverse...

Human nuclear proteins contain >1000 transcriptional effector domains that can activate or repress transcription of target genes. We lack a systematic understanding of which effector domains regulate...

biorxiv.org
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Happy to share a new preprint from the Stadtmueller Lab; great effort by graduate student Qianqiao Liu! The Structures of Secretory IgA in complex with Streptococcus pyogenes M4 and human CD89 provide insights on mucosal host-pathogen interactions biorxiv.org/content/10.1101/…

The Structures of Secretory IgA in complex with Streptococcus pyogenes M4 and human CD89 provide...

Immunoglobulin (Ig) A functions as monomeric IgA in the serum and Secretory (S) IgA in mucosal secretions. Host IgA Fc receptors (FcαRs), including human FcαR1/CD89, mediate IgA effector functions;...

biorxiv.org
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🦠 Revenge of the Microbes 🦠 Congratulations to Dr. Brenda Wilson (Dept. of #Microbiology) on her new book!! 🎉🎉 📗 Check out Wilson's interview with MCB about her ongoing investigation into our war against #pathogens: mcb.illinois.edu/news/2023-0… #scicomm #academicwriting
Picture of Professor Brenda Wilson holding up her book, "Revenge of the Microbes." Text beside photo: "Antibiotics vs. Microbes: Wilson's new book investigates our war against pathogens. In 'Revenge of the Microbes: How Bacterial Resistance is Undermining the Antibiotic Miracle,' University of Illinois microbiology professor Brenda Wilson and co-author Brian Ho analyze our current predicament through a holistic lens that goes beyond pure microbiology to encapsulate how the antibiotic-microbe arms race involves us all."

ALT Picture of Professor Brenda Wilson holding up her book, "Revenge of the Microbes." Text beside photo: "Antibiotics vs. Microbes: Wilson's new book investigates our war against pathogens. In 'Revenge of the Microbes: How Bacterial Resistance is Undermining the Antibiotic Miracle,' University of Illinois microbiology professor Brenda Wilson and co-author Brian Ho analyze our current predicament through a holistic lens that goes beyond pure microbiology to encapsulate how the antibiotic-microbe arms race involves us all."

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Beth Stadtmueller retweeted
Mohammed Kaplan@MMMKaplan_4 Apr 2023
I am very excited for this new start at the department of Microbiology at UChicago @UChicago_Micro ! Thanks to everyone for their help and support throughout the whole process. I’m building up a team so if you are interested please don’t hesitate to contact me.
UChicago Department of Microbiology@UChicago_Micro3 Apr 2023
Please welcome our newest faculty member, Dr. Mohammad Kaplan to Department of Microbiology! He will join us as an Assistant Professor this August. His research program will be focused on studying high resolution macromolecular structures in bacteria. Congrats, Dr. Kaplan!
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Happy to share a new preprint from the Stadtmueller Lab! #Antibodies #cryoEM #IgM The structure of the teleost Immunoglobulin M core provides insights on polymeric antibody evolution, assembly, and function biorxiv.org/content/10.1101/…

The structure of the teleost Immunoglobulin M core provides insights on polymeric antibody evolut...

Polymeric (p) immunoglobulins (Igs) serve broad functions during vertebrate immune responses. Typically, pIgs contain between two and six Ig monomers, each with two antigen binding fragments and one...

biorxiv.org
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The Stadtmueller Lab had a great time sharing and learning new science at the the West Coast Structural Biology Workshop last week! Many thanks to @Yeates_Lab, @OchoaJessicaM, Jose Rodriguez, and Pascal Egea for organizing! #StructuralBiology #WCSBW2023
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Beth Stadtmueller retweeted
The Bjorkman Lab@bjorkmanlab15 Mar 2023
We were fortunate to have Prof Beth Stadtmueller of @StadtmuellerLab and Prof Collin Kieffer visit our lab to share their amazing research since leaving the Bjorklab. We hope you will visit again, and just maybe SoCal will be a little sunnier next time ☀️
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Beth Stadtmueller retweeted
Angad Mehta@angadmehta26 Jan 2023
So excited to work with all of you! @wchnicholas @GuthmillerJenna @StadtmuellerLab and Wilfred! Thanks @HHMINEWS for the support!
U of I School of Molecular and Cellular Biology@MCB_Illinois26 Jan 2023
🔸 #ILLINOIS scientists and a collaborator at @CUAnschutz won $9.5M to study emerging pathogen from @HHMINEWS. 🔹 The team will investigate how to better prevent #birdflu from spreading among animals and humans. STORY: mcb.illinois.edu/news/2023-0… VIDEO: youtube.com/watch?v=FadXmNsy…
Illinois researchers Wilfred van der Donk, Angad Mehta, Nicholas Wu, and Beth Stadtmueller stand posed in a row, smiling for the camera. They are in a lab.

ALT Illinois researchers Wilfred van der Donk, Angad Mehta, Nicholas Wu, and Beth Stadtmueller stand posed in a row, smiling for the camera. They are in a lab.

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REALLY excited about this opportunity from #HHMI to investigate and engineer avian and human antibody responses to influenza with a wonder team: @GuthmillerJenna, @wchnicholas, @angadmehta, and Wilfred van der Donk! @HHMINEWS STORY: mcb.illinois.edu/news/2023-0…
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Beth Stadtmueller retweeted
HHMI
@hhmi_science26 Jan 2023
Today HHMI is announcing a commitment of $100 million to the Emerging Pathogens Initiative. The new effort’s research will target preparedness for future emerging pathogens. Learn more: hhmi.news/3XDQowl
Graphic describing the new HHMI Emerging Pathogens Initiative. Image is divided in half. On the left, on an off white background, text reads, "Collaborating on basic research targeted at preparedness for emerging pathogens that could threaten human health in the future." On the right is a blue and purple photo of MRSA bacteria

ALT Graphic describing the new HHMI Emerging Pathogens Initiative. Image is divided in half. On the left, on an off white background, text reads, "Collaborating on basic research targeted at preparedness for emerging pathogens that could threaten human health in the future." On the right is a blue and purple photo of MRSA bacteria

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Thrilled to share that I’ve been awarded a Michelson Prize Next Generation Grant! Thank you @MichelsonPhils @MichelsonMedRF @ImmunomePro for supporting my new lab’s research on engineering mucosal vaccines @UMNBME
Michelson Medical Research Foundation
@MichelsonMedRF24 Jan 2023
Congratulations to the winners of the 2022 #MichelsonPrizes! @AuslanderNoam @TheWistar, @GuthmillerJenna @CUAnschutz, @guyon1995 @UniofOxford, @Britt_Hartwell @UMNBME are awarded $150,000 research grants to advance immunology! Learn more: michelsonmedicalresearch.org… @ImmunomePro
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