Associate Professor @UofIllinois studying influenza, SARS-CoV-2, antibodies, evolution, and protein structures.
Urbana, IL
Joined December 2014
- Tweets620
- Following323
- Followers882
- Likes1.7K
Nicholas Wu retweeted
This preprint just came out. @wchnicholas and team reconstructed and tested the NJ Spike and found that it has the tightest ACE2 binding of any SC2 Spike ever measured.
2/
medrxiv.org/content/10.1101/…
Nicholas Wu retweeted
This is wild.
Remember the NJ crytic lineage?
I posted 18 months ago that the Spike was too divergent to predict ACE2 binding, and asked if someone else could figure it out.
Some colleagues took me up on it.
Guess what they found?
1/
xitter.cf/SolidEvidence/status/1…
Nicholas Wu retweeted
Excited to share our recent study (collaborated with @wchnicholas @SolidEvidence) of a wild cryptic lineage, NJ, detected in wastewater.
Notably, it carries 39 unique substitutions on the RBD, and exhibits the highest ACE2 binding affinity and extensive antibody evasion.
Nicholas Wu retweeted
Evolution of Ab cross-reactivity to influenza H5N1 NA:
Isolation & characterization of protective antibody against influenza neuraminidase that acquires cross-reactivity to avian H5N1 as a byproduct of affinity maturation against human H3N2 @wchnicholas
cell.com/cell-host-microbe/a…
Nicholas Wu retweeted
Evolution of Ab cross-reactivity to influenza H5N1 NA:
New work isolates & characterizes protective antibody against influenza neuraminidase that acquires cross-reactivity to avian H5N1 as a byproduct of affinity maturation against human H3N2 @wchnicholas
cell.com/cell-host-microbe/a…
Nicholas Wu retweeted
Excited to share that the oPool⁺ display is on the cover of this week's @ScienceTM! We hope that the future use of this platform can accelerate antibody characterization, benefit therapeutic & vaccine development, and facilitate iterative refinements of antibody AI models.
Don't miss the new issue of #ScienceTranslationalMedicine!
A clinical study in Nepal shows that waning immunity to Japanese encephalitis virus can worse the severity of dengue, a new platform leapfrogs laborious obstacles in antibody discovery, and more. scim.ag/3JBJc1Y
Nicholas Wu retweeted
Reaching out to senior scientists can feel daunting, but it’s often less intimidating—and more rewarding—than you’d expect.
In this @ecrLife article, I share my experience as an early-career researcher and encourage others to take that step too.
ecrlife.org/reaching-out-to-…
Nicholas Wu retweeted
New in @JExpMed! 🆕
Researchers alongside Drs. Ali Ellebedy, Nicholas Wu, and @florian_krammer investigated the breadth of anti-NA B cell responses to seasonal #influenza vaccination in humans.
📖 Learn more: bit.ly/3XJ0L4g
Nicholas Wu retweeted
We are hiring a highly motivated postdoctoral fellow to study the molecular biology and pathogenesis of enteric viruses that cause diarrhea in human infants. More details on the Ding Lab website - sdinglab.wustl.edu. DM or email me!
Nicholas Wu retweeted
In this latest version of the preprint, we are excited to (re)introduce oPool+ display, a high-throughput cell-free platform that enables rapid synthesis and specificity characterization of natively paired antibodies at an unprecedented scale (1/): biorxiv.org/content/10.1101/…
Nicholas Wu retweeted
I am excited to share our latest work, where we developed oPool+ display, a rapid and cost-approach to synthesize and screen natively paired antibodies in a highly parallel fashion (1/14): biorxiv.org/content/10.1101/…
Nicholas Wu retweeted
The Ding Lab at the Washington University in St. Louis (sdinglab.wustl.edu/) is hiring! We are looking for motivated postdocs and technicians to study rotavirus biology and vaccines using viral reverse genetics, mouse models, and human intestinal organoids. Spread the word!
Nicholas Wu retweeted
Our paper on SARS-CoV-2 fusion peptide and coronavirus DMS is now available online @NatureComms
Great collaboration with @wchnicholas and @RuipengUIUC !
nature.com/articles/s41467-0…
Nicholas Wu retweeted
I am so glad to receive travel award for #BPS2024. Come to the poster session on Feb 14th(B477 , 10:30 AM - 12:30 PM) to learn about antibody, deep learning and language model! – at Philadelphia, PA
Nicholas Wu retweeted
excited to share that our paper on equivariant model for protein structure to function map, led by Mike Pun, is now published in @PNASNews
pnas.org/doi/10.1073/pnas.23…
Check out our new preprint (led by Mike Pun @UW) on 3D rotationally equivariant model of protein structure micro-environments, with a holographic CNN (H-CNN): doi.org/10.1101/2022.10.31.5…
Nicholas Wu retweeted
I love running, and I love helping people more. In 2024, I want to combine two of my favorite things by running the @ChiMarathon as a @MercyHome hero! Please join me in helping children in need, one step at a time:) #Resolutions2024
marathon.mercyhome.org/chica…
Nicholas Wu retweeted
Stringent and complex sequence constraints of an IGHV1-69 broadly neutralizing antibody to influenza HA stem dlvr.it/Sz4Cs3
Nicholas Wu retweeted
Very nice new paper characterizing anti-N2 mAbs by @wchnicholas and the now twitter-less Ali Ellebedy. Thanks for including my team.
cell.com/immunity/pdfExtende…
Nicholas Wu retweeted
Three protective Abs that cross-react with neuraminidases from seasonal H3N2 strains spanning multiple decades with implications for developing broadly protective influenza vaccines @wchnicholas @ImmunityCP
cell.com/immunity/fulltext/S…
Nicholas Wu retweeted
Phenotypic homogeneity of cells with genomic “landing pad” transgene integration can simplify assays for protein function. We made double landing pad HEK cells that reproducibly allow two independent single-copy integrations, with some new possibilities. pubs.acs.org/doi/10.1021/acs…
