@Yeates_Lab

Lab twitter account for the Todd Yeates group @UCLA

yeateslab.mbi.ucla.edu/
Joined September 2022
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Our new paper that uses machine learning to generate a suite of novel protein cages has just been published: cell.com/structure/fulltext/…

A suite of designed protein cages using machine learning and protein fragment-based protocols

Using machine learning and knowledge-based algorithms, Meador et al. design 24-subunit protein complexes in the shapes of tetrahedral nanoparticles or cages. Structural and biochemical methods...

cell.com
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Our creation of 'ligand-operable cages' -- designed protein cages that disassemble when they bind a specific cellular protein -- has been published: pubs.acs.org/doi/10.1021/acs…

Design of Ligand-Operable Protein-Cages That Open Upon Specific Protein Binding

Abstract. Protein nanocages have diverse applications in medicine and biotechnology, including molecular delivery. However, although numerous studies have

pubs.acs.org
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Our latest work on solving the cryo-EM problem for small therapeutic proteins is finally out. pnas.org/doi/10.1073/pnas.23… Congrats to Roger and the lab!

Cryo-EM structure determination of small therapeutic protein targets at 3 Å-resolution using a...

Cryoelectron microscopy (Cryo-EM) has enabled structural determination of proteins larger than about 50 kDa, including many intractable by any othe...

pnas.org
Roger Castells@rcastellsg9 Sep 2023
I'm thrilled to share our latest work on designing imaging scaffolds to determine the structure of small proteins using cryo-EM! pnas.org/doi/full/10.1073/pn…
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‘Rigidified Scaffolds for 3-Angstrom Resolution Cryo-EM of Small Therapeutic Protein Targets’ Congrats @rcastellsg @kylemeador and team! With our imaging scaffolds, we report a 2.9A structure for a ~19 kDa KRAS protein oncogenic mutant. biorxiv.org/content/10.1101/…
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Designing Protease-Triggered Protein Cages #proteincages #proteases #proteindesign pubs.acs.org/doi/abs/10.1021…
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