@ScaddenLab

Official account of the Scadden Lab at Harvard University and MGH. We study the hematopoietic system in health and disease. Posts by Dr. Scadden are signed DS.

Joined October 2018
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Broad has launched the Biology of Adversity Project, led by @JD_Buenrostro a 2023 @macfound fellow, to uncover how adverse life experiences can inflict molecular “scars” in the genome and body and increase risk of heart disease and other disorders. broad.io/BAP
Jason Buenrostro stands behind a podium speaking to an audience.

ALT Jason Buenrostro stands behind a podium speaking to an audience.

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Mesenchymal cells rebuild the thymus #NBTNV go.nature.com/4r1A8Vp
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Defining Thymic niche cells published today in Nature Biotechnology. Congratulations Karin and wonderful collaborators!! nature.com/articles/s41587-0…
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🎉New article from the @ScaddenLab in @Cell_Metabolism: Disrupting ELMSAN1–nPDC reactivates nuclear acetyl-CoA, rewires cancer epigenetics, and halts tumor growth. A promising strategy for cancer therapy. Read more: doi.org/10.1016/j.cmet.2025.… #MGB #HSCRB
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David Scadden has been named to Clarivate’s 2021 global list of Highly Cited Researchers. His papers rank in the top 1% of citations for his field in the Web of Science database, demonstrating the impressive reach of his influential work.
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A huge team effort under the umbrella of the Boston bone metastases consortium. Targeting CCL20:CCR6 axes relieves immunosuppression in bone met prostate cancer. @ScaddenLab @KharchenkoLab @SykesLabMGH @MGH_RI @Cancer_Cell authors.elsevier.com/c/1dw7q…
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Replying to @ScaddenLab @CellStemCell @harvardstemcell @HSCRB @Mansour
And, of course, congratulations to our first author @KfouryYoumna for the hard and amazing work and for leading this project!
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Our latest paper demonstrating how tiRNA in EVs signal in the BM niche to increase myeloid cell production is out in @cellstemcell. Congrats to the team @harvardstemcell @HSCRB and huge thanks to our collaborators @Mansour, Ivanov lab and Ruslan Sadreyev sciencedirect.com/science/ar…
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Paul Frenette was a cherished colleague and friend whose creativity changed forever how we think about hematopoiesis and the bone marrow niche. His greatness in science was matched by his warmth, kindness and humor. We deeply mourn his loss and celebrate his life. @PaulFrenette
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Our new discovery linking metabolism to mitochondrial biogenesis through ME2 enzyme, in healthy and leukemia cells is now out on @Cell_Metabolism. Congratulations to @YPWang4 and the team! @harvardstemcell @HSCRB sciencedirect.com/science/ar…
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Congratulations to Nick van Gastel who is en route to his own new lab in the deDuval Institute, Brussels, Belgium.
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Delighted to be part of a superb study by Aaron Burberry and Kevin Eggan defining how common ALS variant C9orf72 affects immune response to gut microbes. Microbiome speaks to the brain through blood cells and alters neurodegeneration! Nature 2020 Jun;582(7810):89-94.
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Very exciting work from @EgganLab! Happy to have contributed a small bit to this study. Congrats first author Aaron Burberry and all co-authors! @HSCRB @harvardstemcell @ScaddenLab @mfwells5
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Very happy to have contributed to this study, although most praise should go to @GeertLab and first author @nickvangastel (now a postdoc in @ScaddenLab) for this wonderful and exciting work!
Science in Boston
@ScienceinBoston2 Mar 2020
Scientists in the @ScaddenLab at @harvardstemcell have discovered that the presence of fatty acids in blood at a fracture site drives conversion of #SkeletalProgenitorCells to bone-forming cells, while the absence generates cartilage cells. bit.ly/2T8oqdz
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Scientists in the @ScaddenLab at @harvardstemcell have discovered that the presence of fatty acids in blood at a fracture site drives conversion of #SkeletalProgenitorCells to bone-forming cells, while the absence generates cartilage cells. bit.ly/2T8oqdz
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NEW Perspective by S Méndez-Ferrer et al outlines how the #BoneMarrowNiche contributes to the initiation & the progression of haematological malignancies & suggests guidelines to help overcome existing research challenges. bit.ly/-SMF- @NatResCancer @SCICambridge
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Also thankfull to @HaigisLab and @JessicaSpinel16 for the wonderfull collaboration, and all other co-authors for their contributions @azeem_sharda @baryawno @tokitky @KaoticNeutrofil. #metabolism #Leukemia #chemotherapy #niche @HSCRB @harvardstemcell @MassGeneralCRM
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Very excited to share the latest #preprint from the lab now on Sneak Peek @CellPressNews @SSRN! Congrats first author @nickvangastel on this exciting work identifying transient #metabolic vulnerabilities in #chemoresistant #AML cells! ssrn.com/abstract=3537802#.X…
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Thanks for highlighting our study performed by @nickvangastel with help of @SteveStegen, two amazing young scientists @GeertLab and @ScaddenLab
RegMedNet
@RegMedNet28 Feb 2020
Could we control #stemcell differentiation and #cartilage production by altering the supply of blood and fatty acids? New research from @Harvard and @leuvenU suggests maybe so. Read the latest news on RegMedNet now. bit.ly/2w61qRMN
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Very exciting indeed! This paper has been long in the making and a big thank you to all co-authors @SteveStegen @ACarlier_PhD @VeerleDaniels @Baryawnolab @maarteniFixit @azeem_sharda @triziagos @LambrechtsDlab @SwinnenJohan @LiesbetGeris @bernthie @CarmelietLab @ScaddenLab 1/6
GeertCarmelietLab@GeertLab26 Feb 2020
Very pleased and happy to share our latest publication @Nature showing that lipid starvation during #bone #regeneration promotes chondrogenic fate of skeletal progenitors. Impressive work of @nickvangastel and our team @KU_Leuven @FWOVlaanderen doi.org/10.1038/s41586-020-2…
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