@CellStemCell

A monthly journal at the forefront of stem cell science and policy. Posts & opinions from Editor-in-Chief, Dr. Sheila Chari

 Cambridge, MA
cell.com/cell-stem-cell/home
Joined June 2009
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Meet Eileen Gentleman @GentlemanLab in Bruges @CellPressEvents #CPSOrganoidsNAMs27 and discover how her research is using innovative biomaterials to harness the potential of stem cells for regenerate medicine. Abstract submission deadline: Jan 22, 2027 hubs.li/Q04y4vPS0
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Online Now! Systemic delivery of phagocytosis-shielded retroviral vectors enables in vivo HSC gene therapy for sickle cell disease dlvr.it/TVdKRQ #stemcells

Systemic delivery of phagocytosis-shielded retroviral vectors enables in vivo HSC gene therapy for...

Klatt et al. show that phagocytosis-shielded, BaEVRLess-pseudotyped retroviral vectors transduce human hematopoietic stem cells directly in vivo in mobilized humanized mice. Chemoselection enriches...

cell.com
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Online Now! Immunoids: Building immunocompetent organoids from human pluripotent stem cells dlvr.it/TVdHYM #stemcells

Immunoids: Building immunocompetent organoids from human pluripotent stem cells

O’Hern et al. review advances in modeling immunity and tissue function using self-organizing hPSC-derived immunocompetent organoids, termed “immunoids.” They outline priorities for advancing the...

cell.com
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Congratulations to Jun Takahashi, recipient of the 2026 Ogawa-Yamanaka Stem Cell Prize by Gladstone Institutes (@GladstoneInst) who was selected for pioneering the translation of iPS cell biology into regenerative therapies for Parkinson’s disease. hubs.li/Q04xXhdC0
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Congratulations to Jun Takahashi, recipient of the 2026 Ogawa-Yamanaka Stem Cell Prize by Gladstone Institutes (@GladstoneInst) who was selected for pioneering the translation of iPS cell biology into regenerative therapies for Parkinson’s disease. hubs.li/Q04xXhkF0
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Online Now! Genomic and transcriptomic quality control for an autologous iPSC-derived cell therapy for Parkinson’s disease dlvr.it/TVWyzq #stemcells

Genomic and transcriptomic quality control for an autologous iPSC-derived cell therapy for Parkin...

Bratt-Leal et al. report the preclinical data supporting initiation of a clinical trial investigating autologous dopaminergic neuron precursor cell therapy for moderate to advanced Parkinson’s...

cell.com
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Online Now! H3K27M drives OPC stemness and intrathecal therapeutic vulnerability in brainstem glioma organoids dlvr.it/TVW5qC #stemcells

H3K27M drives OPC stemness and intrathecal therapeutic vulnerability in brainstem glioma organoids

Zhang and colleagues established a patient-derived brainstem glioma organoid (BSGO) platform that preserved tumor microenvironment and enabled mechanistic and therapeutic discovery. They uncovered...

cell.com
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Online Now! Clinical base editing for β-hemoglobinopathies across different genetic backgrounds dlvr.it/TVNgrj #stemcells

Clinical base editing for β-hemoglobinopathies across different genetic backgrounds

Liu et al. demonstrate the clinical efficacy of the transformer base editor in one patient with SCD and three non-Chinese patients with TDT, achieving durable pan-cellular HbF induction, sustained...

cell.com
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Online Now! IGF2 acts downstream of Hippo signaling to regulate organ growth and restore liver regeneration in aging dlvr.it/TVNWqR #stemcells
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📢Present your research in Bruges! We're now accepting abstracts for #CPSOrganoidsNAMs27 from scientists advancing organoids, NAMs, disease modeling, drug discovery, and more. 🗓️ Abstract deadline: January 22, 2027 🔗 hubs.li/Q04wT_170 @CellPressEvents
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Online Now! Endothelialized callus organoids drive rapid regeneration of critical-size segmental long bone defects dlvr.it/TVMwLY #stemcells

Endothelialized callus organoids drive rapid regeneration of critical-size segmental long bone...

Endothelial cells instruct the early developmental program of human periosteum-derived callus organoids. Scalable organoid aggregates guide host-mediated regeneration through endochondral ossificat...

cell.com
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Online Now! Epi-Allele elicits compensatory expression of the non-targeted allele and prevents haploinsufficiency in dominant genetic diseases dlvr.it/TVMsYp #stemcells

Epi-Allele elicits compensatory expression of the non-targeted allele and prevents haploinsuffici...

Zhou and colleagues present Epi-Allele, an allele-specific epigenetic silencing strategy that rebalances allelic expression while preserving total gene output. In HCM models, Epi-Allele silences...

cell.com
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Heart valves enter their organoid era dlvr.it/TVMqGp

Heart valves enter their organoid era

Heart valve research has long lacked accessible human model systems. In this issue of Cell Stem Cell, He et al. and Voges et al. introduce complementary stem cell-derived valve models that recreate...

cell.com
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APOE4 astrocytes call the shots on neuronal α-synuclein pathology dlvr.it/TVMhhz
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Beyond compensation: Organized pathological hematopoiesis in the myelofibrotic spleen dlvr.it/TVKvGT
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Feeling the tension: Engineered stem cells convert tumor stiffness into a drug target dlvr.it/TVKqfS

Feeling the tension: Engineered stem cells convert tumor stiffness into a drug target

Radiopharmaceutical theranostics remains constrained by tumors lacking a validated molecular target. Yang et al. engineer mesenchymal stem cells that sense tumor stiffness and respond by manufactur...

cell.com
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Spatial profiling of the spleen in mouse and human myelofibrosis reveals complement-driven immune-stromal interactions as a therapeutic target dlvr.it/TVKmtD

Spatial profiling of the spleen in mouse and human myelofibrosis reveals complement-driven immune...

Schneider, Dussiau, and colleagues show that splenomegaly in myelofibrosis reflects active remodeling of the splenic stromal niche, not only extramedullary hematopoiesis. Reticular cell-driven...

cell.com
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Splenic extramedullary hematopoiesis in myelofibrosis is shaped by transcriptomic and epigenetic dysregulation dlvr.it/TVKd6r

Splenic extramedullary hematopoiesis in myelofibrosis is shaped by transcriptomic and epigenetic...

Hoffman, Aifantis, Satija, and colleagues show that neoplastic extramedullary hematopoiesis in the spleens of advanced myelofibrosis patients is enriched for erythroid and megakaryocytes progenitors...

cell.com
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Cholesterol dysregulation in APOE4 astrocytes promotes α-synuclein pathology in miBrains dlvr.it/TVK0Fj

Cholesterol dysregulation in APOE4 astrocytes promotes α-synuclein pathology in miBrains

Blanchard and colleagues developed a multicellular integrated brain (miBrain) recapitulating α-synuclein pathogenic accumulation seen in carriers of the APOE4 genetic variant. They identified APOE4...

cell.com
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Engineered mechanosensitive MSCs enable synthetic radiotheranostic targeting across tumor types dlvr.it/TVJyMB

Engineered mechanosensitive MSCs enable synthetic radiotheranostic targeting across tumor types

Many cancers lack suitable molecular targets for radiotheranostics. Liu and colleagues engineer mechanosensitive MSCs that convert tumor stiffness into synthetic expression of clinically actionable...

cell.com
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