@ScaddenLab

Official account of the Scadden Lab at Harvard University and MGH. We study the hematopoietic system in health and disease. Posts by Dr. Scadden are signed DS.

Joined October 2018
  • Tweets71
  • Following130
  • Followers1.5K
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Broad has launched the Biology of Adversity Project, led by @JD_Buenrostro a 2023 @macfound fellow, to uncover how adverse life experiences can inflict molecular “scars” in the genome and body and increase risk of heart disease and other disorders. broad.io/BAP
Jason Buenrostro stands behind a podium speaking to an audience.

ALT Jason Buenrostro stands behind a podium speaking to an audience.

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Mesenchymal cells rebuild the thymus #NBTNV go.nature.com/4r1A8Vp
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A huge team effort under the umbrella of the Boston bone metastases consortium. Targeting CCL20:CCR6 axes relieves immunosuppression in bone met prostate cancer. @ScaddenLab @KharchenkoLab @SykesLabMGH @MGH_RI @Cancer_Cell authors.elsevier.com/c/1dw7q…
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Very exciting work from @EgganLab! Happy to have contributed a small bit to this study. Congrats first author Aaron Burberry and all co-authors! @HSCRB @harvardstemcell @ScaddenLab @mfwells5
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Scientists in the @ScaddenLab at @harvardstemcell have discovered that the presence of fatty acids in blood at a fracture site drives conversion of #SkeletalProgenitorCells to bone-forming cells, while the absence generates cartilage cells. bit.ly/2T8oqdz
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NEW Perspective by S Méndez-Ferrer et al outlines how the #BoneMarrowNiche contributes to the initiation & the progression of haematological malignancies & suggests guidelines to help overcome existing research challenges. bit.ly/-SMF- @NatResCancer @SCICambridge
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Thanks for highlighting our study performed by @nickvangastel with help of @SteveStegen, two amazing young scientists @GeertLab and @ScaddenLab
RegMedNet
@RegMedNet28 Feb 2020
Could we control #stemcell differentiation and #cartilage production by altering the supply of blood and fatty acids? New research from @Harvard and @leuvenU suggests maybe so. Read the latest news on RegMedNet now. bit.ly/2w61qRMN
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Very exciting indeed! This paper has been long in the making and a big thank you to all co-authors @SteveStegen @ACarlier_PhD @VeerleDaniels @Baryawnolab @maarteniFixit @azeem_sharda @triziagos @LambrechtsDlab @SwinnenJohan @LiesbetGeris @bernthie @CarmelietLab @ScaddenLab 1/6
GeertCarmelietLab@GeertLab26 Feb 2020
Very pleased and happy to share our latest publication @Nature showing that lipid starvation during #bone #regeneration promotes chondrogenic fate of skeletal progenitors. Impressive work of @nickvangastel and our team @KU_Leuven @FWOVlaanderen doi.org/10.1038/s41586-020-2…
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Many thanks to all our expert collaborators @ScaddenLab @CarmelietLab @bernthie @ACarlier_PhD @baryawno @triziagos @LambrechtsDlab @SwinnenJohan @LiesbetGeris and non-twitters
GeertCarmelietLab@GeertLab26 Feb 2020
Very pleased and happy to share our latest publication @Nature showing that lipid starvation during #bone #regeneration promotes chondrogenic fate of skeletal progenitors. Impressive work of @nickvangastel and our team @KU_Leuven @FWOVlaanderen doi.org/10.1038/s41586-020-2…
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Very pleased and happy to share our latest publication @Nature showing that lipid starvation during #bone #regeneration promotes chondrogenic fate of skeletal progenitors. Impressive work of @nickvangastel and our team @KU_Leuven @FWOVlaanderen doi.org/10.1038/s41586-020-2…
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I’m very happy to share that our recent study on the characterization of Nestin-GFP+ periosteal progenitor cells, my first paper as last author, was accepted for publication in BONE @ElsevierConnect sciencedirect.com/science/ar… 1/4
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I’ll be recruiting at different levels, so keep an eye for postings in the coming months if you’re interested in #stemcells, #metabolism, #hematopoiesis, #leukemia and/or #Cancer and would like to get to know Belgium and the beautiful city of Brussels.
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I am very happy to announce that I will be joining the @deDuveInstitute in Brussels as a Group Leader in June 2020. My lab will focus on undestanding metabolic crosstalk between cells in the bone marrow niche and its role in leukemia. So exciting!
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ScaddenLab retweeted
Ninad Oak@ninadoak4 Nov 2019
Great talk by David Scadden (@ScaddenLab ) on “​Cancer Through a Stem Cell Lens”. Very interesting to learn about the effect of intra-cellular pH in AML. #DannyThomasLecture @StJudeResearch
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For newbies in the field, watch Hematology 101 lectures from @ISEHSociety with awesome speakers: Elisa Laurenti, @DitaGratzinger, Katrin Ottersbach, Connie Eaves, @ScaddenLab, Gerald de Haan, Timothy Ley, Luigi Naldini, Andrew Elefanty, *for free* at iseh.org/page/hematology101
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ScaddenLab retweeted
Nature Biomedical Engineering@natBME14 Jan 2020
A biomaterial-based vaccine eliciting durable tumour-specific responses against acute myeloid leukaemia rdcu.be/b0i8S
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ScaddenLab retweeted
Harvard SEAS@hseas15 Jan 2020
Researchers have developed an injectable, biomaterial-based vaccine that could lead to more effective treatment of a deadly blood cancer: buff.ly/30nDnu1 @wyssinstitute @harvardstemcell @natBME @NIH @CancerResearch @NSF
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ScaddenLab retweeted
HSCI@harvardstemcell15 Jan 2020
Exciting collaboration from HSCI's @ScaddenLab and Mooney lab:
Harvard SEAS@hseas15 Jan 2020
Researchers have developed an injectable, biomaterial-based vaccine that could lead to more effective treatment of a deadly blood cancer: buff.ly/30nDnu1 @wyssinstitute @harvardstemcell @natBME @NIH @CancerResearch @NSF
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The @ScaddenLab reunion dinner at @ASH_hematology meeting. #ASH19 @purton_louise @jasonbiotech1 @nickvangastel @KfouryYoumna @karinkaninchen and many others!
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Congratulations to the trainee awardees 6th Int'l Conference on #TumorMicroenvironment and #CellularStress: Signaling, #Metabolism, Imaging and #Therapeutic Targets
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