all things epigenetic @KU_Leuven @CHG_CME
Joined February 2011
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🚨Super proud of a new publication from our lab spearheaded by @MarieDeBorre, together with @UZLeuven, @ZOLziekenhuis and @azsintjan. We provide proof-of-concept that cell-free DNA (cfDNA) methylome analysis allows for early preeclampsia (PE) prediction. rdcu.be/dla4e
Bernard Thienpont retweeted
📢 #JobAlert The research group of @bernthie is looking for a lab technician. You can contribute to various interesting research projects. Apply before 11/03:
kuleuven.be/personeel/jobsit…
Bernard Thienpont retweeted
Volg morgen en overmorgen van 10 u. tot 16 u. alle 𝟲𝟬𝟬 𝗦𝗘𝗖𝗢𝗡𝗗𝗘𝗡𝗟𝗘𝗭𝗜𝗡𝗚𝗘𝗡 tijdens @KU_Leuven Inside live op ROBtv. #robnieuws #robtv
Bernard Thienpont retweeted
LISCO is looking for an experienced Business Developer in Single-Cell and Spatial Multi-Omics for Biomedicine to take our cutting-edge lab services and research capabilities to the next level.👉 Apply here: kuleuven.be/personeel/jobsit… or feel free to share with your network!
Bernard Thienpont retweeted
Researchers from the CME @UZLeuven @KU_Leuven developed a new technique that combines #genetic and #epigenetic analyses. This opens the door to faster diagnosis and more insight into the cause of #rarediseases. Covered in the national news 👇
vrt.be/vrtnws/nl/2025/01/15/…
Bernard Thienpont retweeted
Are you active in #sequencing and want to show your research to leading researchers? Submit an abstract for #RNGS25: vibbio.tech/3ZY5IYl
Present on stage with a poster pitch or during the poster sessions.
The abstract deadline is 15 January 2025.
#ngs #genomics #multiomics
Bernard Thienpont retweeted
Many thanks @NatMetabolism for publishing and highlighting our research, all members of our lab, the excellent collaboration with @bernthie and especially first author @SteveStegen
Top Citations 2024: #20🏆✨
@GeertLab (@KU_Leuven) and co-authors describe the role of the serine synthesis pathway in osteoclast differentiation through #epigenetic regulation of NFATc1 expression 🦴🧫
nature.com/articles/s42255-0…
Bernard Thienpont retweeted
We are recruiting PhD students in cancer and metastasis biology! This is a fantastic program that brings together several leading European research institutes. Details below 👇.
📢 Calling all future cancer researchers! Adaptmet is offering 16 MSCA PhD positions in cutting-edge metastasis research. Join us to shape the future of cancer science with exciting projects among Europe’s best teams from top host institutions! Apply now 👉adaptmet.eu/recruitment/
Bernard Thienpont retweeted
🏆Congrats to our PhD researchers Mio Aerden (@bernthie lab) and Yente Monnens (@JohnCreemers lab) for winning the 1st and 2nd prize at the Genetics Retreat NVHG graduate meeting. #proud
klinischegenetica.mumc.nl/ge…
Bernard Thienpont retweeted
Lannoo et al. examined whether rare autosomal trisomies revealed by noninvasive prenatal screening reflect fetal trisomy or confined placental mosaicism and whether they are associated with ⬆️ likelihood of adverse perinatal outcomes. Full correspondence: nej.md/3RVX34b
ALT Bar chart of the outcome of pregnancy according to (mosaic) fetal trisomy or confined placental mosaicism and according to chromosome.
Bernard Thienpont retweeted
We have a new 'Dr. House' in the house! PhD researcher Benjamin Huremagic participated in the #undiagnosedhackathon2024. Together with a bioinformatician from @UAntwerpen solving a case in only 2 hours: nieuwsblad.be/cnt/dmf2024060…
@KU_Leuven @Nieuwsblad_be @JorisVermeesch
amazing work and thoroughly deserved by @KateEStanley1 !
Bernard Thienpont retweeted
Prof. Joris Vermeesch shares updates on Implementing Genome Sequencing to Solve Rare Disease Cases in Belgium: Learnings from the Nationwide RCT BeSolveRD #ESHG2024
Bernard Thienpont retweeted
@bernthie highlighting his recent multi-omics review (free to read link in quoted tweet) now at #ESHG24
Happy to share our deep dive into Methods and applications for single-cell and spatial multi-omics @NatureRevGenet, with the magnificent Katy Vandereyken, Alejandro Sifrim & Thierry Voet from the @KU_Leuven Institute for Single Cell Omics @CHG_CME
rdcu.be/c6JjL
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Welcome to the last day of #eshg2024! Tune in on one of our symposia or educational sessions starting now.
Bernard Thienpont retweeted
.@RidderKobe @bernthie comprehensively benchmark DNA methylation-based deconvolution methods, evaluating their performance and robustness to technical bias. #BiotechNatureComms @NatureComms
nature.com/articles/s41467-0…
paper alert 🚨Figuring out the cellular composition of tissues is essential for understanding diseases. DNA methylation analysis is particularly suited for this task, as deconvolution algorithms can untangle mixture signals from bulk samples into their individual components.
For sequencing-based DNA methylomes, we also assessed how sequencing depth and uniformity affect performance. This resulted in a nuanced set of recommendations for optimal deconvolution, depending on the underlying research question and goal.
Thanks to @ridderkobe for expertise, persistence and diligence, to other members of the lab and reviewers for their insights, and @FWOVlaanderen and @Stkstichting for support! Happy deconvolving to you all! rdcu.be/dH55V