*Innate* immunologist - Dendritic cells, neutrophils, macrophages and their metabolism Junior Group Leader @IRBBarcelona
Joined September 2019
- Tweets614
- Following373
- Followers962
- Likes2.7K
Stefanie Wculek retweeted
We are looking for a highly motivated postdoctoral researcher to join our team at the Medical University of Vienna.
The translational project will investigate how metabolic programs regulate granuloma formation and disease progression in sarcoidosis.
🤖 Made with AI
Stefanie Wculek retweeted
🤔Do you think that OXPHOS in DCs = tolerance?
🚨In our new @Cell_Metabolism study @CNIC_CARDIO , we show that active #mitochondrial ETC primes cDC1s for immunogenicity, boosting anti-tumor immunity.
Life (and #immunometabolism) is not simple ⚡️(1/9)
OPEN: cell.com/cell-metabolism/ful…
Stefanie Wculek retweeted
Mitochondrial metabolism regulates the immunogenic responsiveness of dendritic cells @Cell_Metabolism
cell.com/cell-metabolism/ful… @SWculek @IRBBarcelona
Stefanie Wculek retweeted
Researchers at @CNIC_CARDIO and @IRBBarcelona uncover a key mechanism that keeps immune cells on alert, opening new paths for for vaccines and cancer immunotherapy, via @EurekAlert eurekalert.org/news-releases…
Stefanie Wculek retweeted
Mitochondria keep key immune cells battle-ready by sustaining electron flow, study from @CNIC_CARDIO led by @SanchoLab reveals medicalxpress.com/news/2026-… via @medical_xpress
Stefanie Wculek retweeted
💡⚡ Un equipo del @CNIC_CARDIO demuestra que las #mitocondrias activas mantienen a las células dendríticas listas para responder. Este hallazgo establece un vínculo directo entre el metabolismo celular, la regulación génica y la activación de las células T y abre nuevas vías para mejorar #vacunas e #inmunoterapia contra el #cáncer.
El trabajo, liderado por @sancholab desde el CNIC y por @SWculek desde el @IRBBarcelona, con @NachoHM3 (CNIC) como primer autor, cuestiona la idea tradicional de que las mitocondrias desempeñan un papel menor durante la activación de las células dendríticas.
🔗DOI: cell.com/cell-metabolism/ful… 🔓#OpenAccess en @Cell_Metabolism
📰 Lee aquí la noticia completa: cnic.es/es/noticias/mitocond…
#CNIC #InvestigaciónCardiovascular #Ciencia #Inmunobiología
Stefanie Wculek retweeted
💡⚡ A team from @CNIC_CARDIO has shown that active #mitochondria keep dendritic cells primed to respond. This finding establishes a direct link between cellular metabolism, gene regulation and T-cell activation, and opens up new avenues for improving #vaccines and #immunotherapy against #cancer.
The study, led by @sancholab from the CNIC and @SWculek from @IRBBarcelona, with @NachoHM3 (CNIC) as first author, challenges the traditional view that mitochondria play a minor role during the activation of dendritic cells.
🔗 DOI: cell.com/cell-metabolism/ful…🔓 #OpenAccess in @Cell_Metabolism
📰 Read the full story here: cnic.es/en/noticias/mitochon…
#CNIC #CardiovascularResearch #Science #Inmunobiology
Stefanie Wculek retweeted
Don't miss the 2nd Conference of the European ImmunoMetabolism Network - EIMN2026 .
📅10-12th June 2026
📌Luxembourg
immunometnet.eu/
@ImmunoMetEurope
linkedin.com/events/2ndconfe…
Stefanie Wculek retweeted
#InterferonPower! Thrilled for our latest work @CellCellPress! With @dfrboehmer, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free link 👉 authors.elsevier.com/a/1leKG…
Stefanie Wculek retweeted
This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥
Stefanie Wculek retweeted
I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13)
nature.com/articles/s41586-0…
Stefanie Wculek retweeted
🙏 for wonderful summary @manuelansede
🙏 @FundlaCaixa @CaixaResearch for funding (1M€)
🙏 @AgEInves @CienciaGob for Severo Ochoa to initiate the project and additional funding
🙏 @ERC_Research ERC-CoG ERC-POC
@CNIC_CARDIO
nature.com/articles/s41586-0…
Revolution in medicine: A molecule produced by gut bacteria causes atherosclerosis, responsible for millions of deaths. The discovery, by @SanchoLab, opens the door to new treatments beyond reducing cholesterol english.elpais.com/health/20…
Stefanie Wculek retweeted
🙏 @manuelansede por el fantástico artículo!
🙏 @annalaura_mstrn & Iñaki Robles-Vera @Teriyaky_852 por liderar el proyecto
🙏coautores que han hecho posible el trabajo
🙏@FundLaCaixa @CaixaResearch principal financiador
🙏 @AgEInves @CienciaGob @ERC_Research apoyo adicional
Revolución en la medicina: una molécula producida por bacterias del intestino causa la aterosclerosis, culpable de millones de muertes. El descubrimiento, del @SanchoLab, se acaba de publicar en la revista @Nature 👇 elpais.com/salud-y-bienestar…
Stefanie Wculek retweeted
💥 A gut microbe metabolite that drives #atherosclerosis?
Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol.
🧪 We show the pathway—and how to block it.
nature.com/articles/s41586-0… #OpenAccess at
@Nature
@CNIC_CARDIO
#microbiome #CVD
Stefanie Wculek retweeted
🧬 Major milestone for CNIC research! Three projects involving @CNIC_CARDIO @SaludISCIII have been awarded @ERC_Research Advanced Grants 2024, bringing in a total of €5.25 million
♥️MINTRAF, led by José Antonio Enríquez @GenoxphosLab del @CNIC_CARDIO y el @CIBERFES, will explore how cells communicate via mitochondrial transfer.
♥️ ANTI-ATHERO, led by @aramiro_ramiro, will study age-related immune mechanisms in atherosclerosis.
♥️ Nab Heart, led by Prof. Silvia G. Priori, will develop nanobody-based therapies for cardiac arrhythmias — with part of the research carried out at CNIC.
👏 Congratulations to all the brilliant scientists behind these groundbreaking projects!
#ERCAdvancedGrant #CNIC #ResearchExcellence #Cardiology #HealthInnovation #HorizonEurope #ScienceLeadership
Stefanie Wculek retweeted
Congrats to my close friends at @CNIC_CARDIO in a brilliant and deserved success!!! Exciting projects ahead! 👏🏻👏🏻👏🏻👏🏻👏🏻
🧬 Major milestone for CNIC research! Three projects involving @CNIC_CARDIO @SaludISCIII have been awarded @ERC_Research Advanced Grants 2024, bringing in a total of €5.25 million
♥️MINTRAF, led by José Antonio Enríquez @GenoxphosLab del @CNIC_CARDIO y el @CIBERFES, will explore how cells communicate via mitochondrial transfer.
♥️ ANTI-ATHERO, led by @aramiro_ramiro, will study age-related immune mechanisms in atherosclerosis.
♥️ Nab Heart, led by Prof. Silvia G. Priori, will develop nanobody-based therapies for cardiac arrhythmias — with part of the research carried out at CNIC.
👏 Congratulations to all the brilliant scientists behind these groundbreaking projects!
#ERCAdvancedGrant #CNIC #ResearchExcellence #Cardiology #HealthInnovation #HorizonEurope #ScienceLeadership
Stefanie Wculek retweeted
EVIDENCE OF SOMATIC EVOLUTION IN tRNA genes!!!!
This finding could revolutionize what we know about cancer and somatic evolution in aging. Coming from the wizard of tRNA himself, Lluis Ribas, and genomeologist extraordinaire Fran Supek!
biorxiv.org/content/10.1101/…
Stefanie Wculek retweeted
🔬 1/4
Cancer research advances faster when connected globally.
The Scientific Foundation (@contracancerINV ) joins @TheMarkFdn to support a major international project on colorectal cancer metastasis. 👇
#Cancer #Oncology #research
Stefanie Wculek retweeted
We are looking for 1 mid-career scientist (and postdocs) willing to join us as SR-Tiget in Milan. Basic and translational immunology, gene and cell therapy, genome/protein tech, computational biology... all welcome 💚🤍❤️
check the Call, pls RT!
fondazionetelethon.it/en/wha…
Stefanie Wculek retweeted
Absolutely thrilled to share with you the final version of EPIclone, out now (open access) in @Nature.
This has been an amazing collaboration with the lab of Lars Velten (@larsplus) at @CRGenomica
nature.com/articles/s41586-0…