Nacho retweeted
🤔Do you think that OXPHOS in DCs = tolerance?
🚨In our new @Cell_Metabolism study @CNIC_CARDIO , we show that active #mitochondrial ETC primes cDC1s for immunogenicity, boosting anti-tumor immunity.
Life (and #immunometabolism) is not simple ⚡️(1/9)
OPEN: cell.com/cell-metabolism/ful…
Nacho retweeted
Mitochondrial metabolism regulates the immunogenic responsiveness of dendritic cells @Cell_Metabolism
cell.com/cell-metabolism/ful… @SWculek @IRBBarcelona
Nacho retweeted
New! Online now: Mitochondrial metabolism regulates the immunogenic responsiveness of dendritic cells dlvr.it/TS3VcC
Nacho retweeted
🚨Put a dendritic cell (DC) in your tumor #immunotherapy!
cDC1-based vaccines induce strong effector & memory anti-tumor T cell response. Improved immune memory prevents tumor relapse! @CNIC_CARDIO @AgEInves @contracancerINV @FundlaCaixa @WorldwideCancer
nature.com/articles/s41467-0…
Nacho retweeted
After a hectic summer, a new and extremely exciting adventure has started. I will be leading the cancer genomics group at the newly created Botton-Champalimaud Pancreatic Cancer Centre in Lisbon, Portugal! 🍀💫☀️ @ChampalimaudF @Neuro_CF
Nacho retweeted
🙏RT
📅Abstract deadline DC2024 Barcelona 30th May
🚨 SUBMIT NOW 👇
dc2024barcelona.com/index.ph…
🔬34 short talks + posters!!!
🔝🌍speakers
dc2024barcelona.com/index.ph…
support by: @SEinmunologia @SCImmunologia @EuMacDcSoc
Sponsors:
🥇@miltenyibiotec
🥈@inmunotek
🥉@BioLegend
@EMBO
Nacho retweeted
Delighted to share our latest work, out in @NatImmunol, tackling the seemingly inordinate complexity of #cDC2s. @ReiseSousaLab @TheCrick, we found that distinct ontogenetic lineages dictate cDC2 heterogeneity, rather than cell states imposed by the tissue microenvironment 🧵(1/x)
Nacho retweeted
Our latest review on DCs in anticancer immunity @NatRevClinOncol updates on DC lineages and states in the tumor in the single-cell era, diversity in different human cancers, clinical trials, DCs in current & future cancer immunotherapy.
Free link: rdcu.be/dx3MA
This new Review describes the roles of dendritic cells (DCs) as orchestrators of anticancer immunity, focusing on novel insights on DC heterogeneity gleaned from single-cell studies & how this knowledge might be leveraged to improve immunotherapy: nature.com/articles/s41571-0…
Nacho retweeted
To celebrate the new year, our work on complex genome rearrangement in osteosarcomas! Many thanks to all co-authors, in particular Solange de Noon, Adrienne Flanagan from @uclcancer and @isidrolauscher. Preprint at biorxiv.org/content/10.1101/… and thread below, by @isidrolauscher 👇
To close 2023, we present our work on #osteosarcoma genome and clonal evolution biorxiv.org/content/10.1101/… How does #osteosarcoma arise? What rearrangement mechanisms cause some of the most complex #chromothripsis events seen in human cancer? Does chromothripsis occur subclonally?👇
Nacho retweeted
Se acaban de publicar (1ª vez en humanos) los resultados fase I de una vacuna frente al #VIH q induce Ac neutralizantes de amplio espectro, frente a múltiples serotipos del virus, mediante la estrategia de vacunación dirigida a "linea germinal"
science.org/doi/10.1126/scie…
Nacho retweeted
Our Precision Immune Engineering Lab website is finally live 🍾🎆 We are recruiting MS and PhD students!! Pls check our website if you are interested in therapeutic T cell engineering and send an inquiry to me with a CV👇👇 biomed.drexel.edu/labs/huang…
Nacho retweeted
Buenas noches #tetuaneros❕❗️❕ Hoy vamos a hablar de como un mareo comunitario y vecinal ha ido derivando a nuevos proyectos y nuevos materiales. Incluso creando mapas!! porque se pueden crear y todo...
y...
¿A quién no le gustan los mapas?
Nacho retweeted
Cada punto es importante porque afecta a un/a compa del sector de la #investigación.
Este #7F te esperamos‼️✊
Game changer!
Vaccines that reduce infection & disease are needed to combat the pandemic. Here, @tianyangmao @BenIsraelow et al. describe our new mucosal booster strategy, Prime and Spike, to induce such immunity via nasal delivery of unadjuvanted spike vaccine 🧵 (1/)
biorxiv.org/content/10.1101/…
Nacho retweeted
Al hilo de la decisión de administrar 3a dosis de forma generalizada >18a, explico mi posición en contra aunque avanzo q echo mucho de menos un debate serio en sede oficial con las soc científicas implicadas antes de tomar estas decisiones 👇🏼👇🏼👇🏼
Nacho retweeted
Charles Janeway necesitó años de estudio e investigación, para proponer en 1989 que, para que una respuesta inmunitaria tenga lugar, hacen falta 2 tipos de señales: el antígeno, reconocido por los linfocitos y un adyuvante, reconocido por las células de la inmunidad innata.🧵
