@SanchoLab
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Passionate about #immunology. Sensing damaged self, infections & microbiota by DCs and macrophages to ignite innate & adaptive immunity. #Immunometabolism
Professor @CNIC, Madrid, Spain
Joined September 2019
- Tweets1.7K
- Following916
- Followers3.3K
- Likes2.3K
Pinned Tweet
Does #mitochondrial #respiration in DCs just “fuel” activation?
In our new @SciImmunology study, we show that mitochondrial Complex I is a selective checkpoint for #antigen #cross-presentation in #DCs, especially #cDC1s
science.org/doi/10.1126/scii…
@CNIC_CARDIO
David Sancho retweeted
Delighted to share our paper out today in @NatImmunol on the overlooked role of monocytes in the uterus. It has been quite a journey! @UoM_DIIIRM @LydiaBeckerIII
nature.com/articles/s41590-0…
🙏a la Fundación Caja Rural de Granada @Cajaruralgr por su apoyo a los científicos. Premio compartido con Annalaura Mastrangelo @annalaura_mstrn (metabolómica y diagnosis humana) e Iñaki Robles-Vera @Teriyaky_852 (causalidad y relevancia in vivo). 🙏39 autores (Spain & abroad)🌍
🏆 El investigador del @CNIC_CARDIO David Sancho (@sancholab) recibe el XXII Premio Ciencias de la Salud Fundación Caja Rural Granada @Cajaruralgr por un estudio publicado en @Nature que identifica el propionato de imidazol como un nuevo factor causante y una posible diana terapéutica frente a la #aterosclerosis.
✍️ Más info: cnic.es/es/noticias/david-sa…
¡Enhorabuena por este reconocimiento! 👏
#CNIC #Investigación #Ciencia #InvestigacionCardiovascular
David Sancho retweeted
Almost 15 years after our initial observation that IRE1 is specifically active in cDC1s, we finally start understanding why…
Check out the new study from @victor.bosteels, published in @natcomms.nature.com
Paper in press @ rdcu.be/fur4Q
David Sancho retweeted
Thrilled to share our latest work, now published in @ScienceTM! We show that targeting mitochondrial energetics can simultaneously improve metabolic and vascular health.
Learn more: science.org/doi/10.1126/scit…
@SinaiHeartBlood @IcahnMountSinai
Siempre la recordaremos con su gran empuje, energía y alegría. Un fuerte abrazo a familia y amigos y a todo el @CNB_CSIC 🫂🫂🫂
✝️ Hoy ha fallecido la Dra. Ana Carrera tras una larga lucha contra su cáncer de pulmón. Una gran científica y persona. La echaremos de menos. Un abrazo a su familia y colegas de @CNB_CSIC. Que la tierra le sea leve. Nuestras condolencias desde el @ciccancer. @CSIC @ASEICAnews
Wonderful list on the latest metabolism -related papers ellaborated by Cristina @apoptosislab!!! 👏🏻👏🏻👏🏻👏🏻
Cancer metabolism, inmunometabolism,
Mitochondria, metabolic stress, cancer cachexia, hypoxia and more
Metabolist May 2026
metabolist.wordpress.com/202…
David Sancho retweeted
Cancer metabolism, inmunometabolism,
Mitochondria, metabolic stress, cancer cachexia, hypoxia and more
Metabolist May 2026
metabolist.wordpress.com/202…
David Sancho retweeted
Papers like this are why science remains endlessly exciting. This one made me feel the same wonder I felt at 15 when I first discovered science. || Homing pigeon navigation relies on superparamagnetic macrophages under overcast conditions | Science science.org/doi/10.1126/scie…
How does oxygen sensing shape alveolar #macrophage (AM) identity?
In our new @CellReports HIF-1α and HIF-2α play distinct, non-redundant roles in AM maturation & function
A #metabolic split that defines macrophage biology in the lung.
OPEN: sciencedirect.com/science/ar…
@CNIC_CARDIO
🏡Take home:
Oxygen sensing splits macrophage identity:
👉 HIF-1α → glycolysis & immature state
👉 HIF-2α → lipid metabolism & surfactant clearance
Together, they define maturation, self-renewal, and function.
OPEN ACCESS: sciencedirect.com/science/ar…
Led by @elenapriegosaiz @ireneab2 & Helena M. Izquierdo @CNIC_CARDIO
Thx to collb and funders:
@AgEInves @CienciaGob @ERC_Research @ComunidadMadrid @contracancerINV @ContraCancerEs @WorldwideCancer @criscancer @FundlaCaixa @CaixaResearch
OPEN ACCESS: sciencedirect.com/science/ar…
David Sancho retweeted
✨🗞️ Las #mitocondrias controlan la activación de las células inmunitarias y la eficacia de la #inmunoterapia, según un estudio del @CNIC_CARDIO liderado por @SanchoLab lasexta.com/constantes-vital… via @constanteyvital | @laSextaTV
David Sancho retweeted
HIF-1α and HIF-2α differentially regulate alveolar macrophage maturation and function @CellReports
cell.com/cell-reports/fullte… @SanchoLab
David Sancho retweeted
Great talk at #EASCongress2026 on plaque regression in #atherosclerosis using spatial transcriptomics: regression shows a distinct lipid‑driven signature, with #Nestin⁺#macrophages and #Treg interaction via IGF1–IGF1R. Blocking this axis prevents regression!
