@PatrickSandoz

Assistant Professor at SciLifeLab / Uppsala University. Interested in immune cell signaling, microphysiological systems and biophysics.

 Stockholm, Suède
Joined October 2018
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  • Following400
  • Followers138
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Sandoz Patrick retweeted
Quirin Hammer@QuirinHammer8 Jul 2024
Happy to share the final work from my post-doc with @MalmbergLab published in @CellStemCell today cell.com/cell-stem-cell/full… extensive 15-post-🧵 below
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Happy to see our story on tolerance to inflammation antigens @NatImmunol nature.com/articles/s41590-0… It grew from a naive question I had at my first immunology class: if some self molecules are only induced by pathogen how does immune system distinguish them from foreign antigens?1/n

Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces...

Nature Immunology - The thymus harbors a complex constitutively active inflammatory network with innate-like T cells representing one of its central nodes. Here, the authors show that these cells...

nature.com
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Sandoz Patrick retweeted
Erdinc Sezgin@Sciezgin16 Jan 2024
⚡️New preprint out! #Immunology #biophysics 1/ We show hidden functional immune cell states based on collective membrane properties, which are not directly visible via cell surface markers. biorxiv.org/content/10.1101/…

High-throughput analysis of membrane fluidity unveils a hidden dimension in immune cell states

Cell membranes undergo biophysical remodelling as an adaptation to the surroundings and to perform specific biological functions. However, the extent and relevance of such changes in human immune...

biorxiv.org
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Sandoz Patrick retweeted
VDG Lab @ EPFL@VDGLab21 Nov 2023
Our paper is now out! Cell damage regulates expression of lipid-modifying enzymes via alternative transcription. @SARSCoV2 exploits this to boost Spike #acylation #palmitoylation and generate more infectious #virions! @FS_Mesquita @AbramiLaurence nature.com/articles/s41467-0…
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Wonderful to see our work finally published @NatureComms! Big congratulations to all the collaborators @onfeltlab, @MalmbergLab, @ealici and especially to Kyra for her first Ph.D. article! @scilifelab @KTHuniversity nature.com/articles/s41467-0…

Modulation of lytic molecules restrain serial killing in γδ T lymphocytes

Nature Communications - γδ T cells are unique T lymphocytes with cytotoxic functions, targeting infections and tumours. Here authors show that the target killing function of γδ...

nature.com
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Interestingly, their lytic potential is higher on the 3rd/4th day rather than after a 14-day expansion which corresponds with the granzyme B expression peak.
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An important limitation for serial killing is the low amount of perforin available and the lack of synergy between granzyme B and perforin. The γδ T cells that generated higher co-occurrence of granzyme B with perforin in the lytic vesicles correlated with longer killing series.
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We are desperately looking for IL17RA-/- mice in Europe for a really cool gdT cell project. Would anyone know who might have them?
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Sandoz Patrick retweeted
SciLifeLab@scilifelab8 Mar 2023
“Women today still have to fight in an arena with unspoken rules and an agenda that are set by men” says Ylva Engström, Chair of the SciLifeLab board & Professor at @stockholmuniversity. #EmbraceEquity #IWD2023 #InternationalWomensDay
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Very excited to see our work from my time as a PhD @VDGLab finally published! Big congratulations to the entire team for such a resilience! @gvdgoot @Vassily_13 @FS_Mesquita @homotopykat @labriataphd @AbramiLaurence #organelle #Endoplasmic_Reticulum #ER #acylation
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Sandoz Patrick retweeted
Erdinc Sezgin@Sciezgin15 Oct 2022
can't stop watching this! A fascinating example of dynamism inside a cell #microtubules
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Sandoz Patrick retweeted
Sarahi L. Garcia@sarilog26 Jul 2022
My friend @DelemotteLab is preparing for a class on data-driven life sciences. The main aim is to teach how to read quantitative biology. Do you have a suggestion where large datasets are analyzed using some modeling/machine learning. A plus if the data/code is openly accessible
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We are looking for a postdoc bioinformatician for very exciting single cell multiomics projects. Please spread the word. ki.varbi.com/position/applic…
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Sandoz Patrick retweeted
Erdinc Sezgin@Sciezgin21 Feb 2022
With @LeventalLab , we are organizing a special issue for @BiophysJ "Membranes in Focus" open for microscopic, spectroscopic, and computational investigation of biomembranes. If you are at #bps2022 catch @LeventalLab to discuss. Submit your work by June 30th.
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Sandoz Patrick retweeted
Erdinc Sezgin@Sciezgin26 Jan 2022
A short review on cell-derived giant plasma membrane vesicles (GPMVs).. their recent applications on phase separation, lipidomics, drug delivery, lipid-protein interactions and membrane dynamics.. their limitations and potential future developments.. sciencedirect.com/science/ar…
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Sandoz Patrick retweeted
Li Tang@Tang_Lab_EPFL7 Dec 2021
Our lab's new paper (rdcu.be/cCL0H) is now out at @NatBME. We discovered that cancer cells lower their cortical stiffness, which impedes T cell-mediated cytotoxicity by decreasing T cell force at the immune synapse (doi.org/10.1038/s41551-021-0…) (1/)
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We gladly invite you to attend our second mental health event in the series "Our community, Ourselves" Title: Nurturing wellbeing in academia When: November 18th, 14:15 We will have Dear Academia, Deborah Rupert, and @slumraofsweden deborahrupert.com/dear-acade…
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Sandoz Patrick retweeted
VDG Lab @ EPFL@VDGLab7 Oct 2021
Our work is out! We are happy to share how #Palmitoylation controls #SARSCoV2 (#Covid19) #membrane #Cholesterol organization, and promotes #infection cell.com/developmental-cell/…

S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity

Mesquita et al. report that SARS-CoV-2 spike protein undergoes massive lipid modification during viral biogenesis. This controls the membrane, in particular cholesterol, composition of the envelope...

cell.com
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