@VDGLab

News from the Laboratory of Cell and Membrane Biology (Gisou van der Goot Lab) at EPFL in Lausanne, Switzerland.

 Lausanne, Switzerland
epfl.ch/labs/vdg/
Joined July 2019
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Our paper is now out! Cell damage regulates expression of lipid-modifying enzymes via alternative transcription. @SARSCoV2 exploits this to boost Spike #acylation #palmitoylation and generate more infectious #virions! @FS_Mesquita @AbramiLaurence nature.com/articles/s41467-0…
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Late publicity! Check our last review regarding the wonderful world of S-#acylation aka #Palmitoylation. A comprehensive overview of the field and our take on the interplay between this #lipid #PTM and #immunity #metabolism #cancer and #brain. rdcu.be/dEk2w
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A fantastic collaborative effort! Congrats to all involved! @FS_Mesquita @AbramiLaurence @MaurineLinder10 @ShernazBamji @chembioBryan and Gisou van der Goot! @NatRevMCB
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Now Online Mechanisms and functions of protein S-acylation dlvr.it/T2l8H8
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💡Viewpoint💡 💫S-acylation: an orchestrator of the life cycle & function of membrane proteins💫 ✍️By @FS_Mesquita, F. Gisou van der Goot et al from @EPFL_en ➡️buff.ly/3TJsBMF #deacylation #ERassociateddegradation #palmitoylation #proteinturnover #Sacylation #OpenAccess
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Big thanks to all our collaborators and everyone from the @VDGLab @Trono_Lab @ACCESS_Unige. Learn more about the details of how cell damage caused by #viruses #toxins or #colitis regulates protein #acylation #palmitoylation, check it out!
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Delighted to share our take on the only reversible lipid PTM--S-acylation as a major regulator of protein dynamics and function and its implications in health and disease in @JCellBiol . @gvdgoot Thanks so much. Proud! Highlights in thread (1/7) rupress.org/jcb/article/222/…
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Review: S-acylation is one of the most frequent posttranslational modifications that regulates diverse cellular processes. @MUmairanwar1 and @gvdgoot @EPFL_en discuss the complexity and disease implications of this highly regulated reversible lipidation. bit.ly/3ta9gsE
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#SARS2 #Lipidation Chapter2. How #SARSCoV2 boosts Host #Palmitoylation to promote infectivity! #Infection shifts transcription of ZDHHC20 palmitoyltransferase to increase #Spike Palmitoylation and produce more infectious #virus Stay tuned for Chapter3 biorxiv.org/content/10.1101/…
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The N-terminal extension of ZDHHC20 prevents the protein from leaving the ER, extends its half-life, and enhances its #Spike modifying capacity by more than 35 times!
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Finally, we show that #viruses produced by Long-ZDHHC20-expressing cells have enhanced infectivity. More details in the manuscript!
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Is there more than transcriptional programs to drive cell identity? Here with @GioeleLaManno we discuss the lipotype hypothesis nature.com/articles/s41580-0… – at Lausanne, Switzerland
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ER-Golgi-localized proteins TMED2 and TMED10 control the formation of plasma membrane lipid nanodomains cell.com/developmental-cell/…

ER-Golgi-localized proteins TMED2 and TMED10 control the formation of plasma membrane lipid...

Anwar et al. show that organization of the plasma membrane into nanodomains, which are required for anthrax intoxication, depends on the transfer of cholesterol at sites where the endoplasmic...

cell.com
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This was really a nice journey … thank you @MUmairanwar1 , @oxyquips and @AbramiLaurence for taking us this far… – at Lausanne, Switzerland
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Thanks to all involved, in particular @oxyquips @AbramiLaurence @gvdgoot @Gio_Dangel0. @VDGLab we have to celebrate. 2/2
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How are membrane nanodomains formed? Delighted to share our preprint where we show that plasma membrane compartmentalization is controlled by rapid lipid composition remodeling at the ER-Golgi contact sites. (1/4) biorxiv.org/content/10.1101/…

Anthrax intoxication reveals that ER-Golgi membrane contact sites control the formation of plasma...

To promote infections, pathogens exploit host cell machineries including structural elements of the plasma membrane. Studying these interactions and identifying involved molecular players is an ideal...

biorxiv.org
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Our work is out! We are happy to share how #Palmitoylation controls #SARSCoV2 (#Covid19) #membrane #Cholesterol organization, and promotes #infection cell.com/developmental-cell/…

S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity

Mesquita et al. report that SARS-CoV-2 spike protein undergoes massive lipid modification during viral biogenesis. This controls the membrane, in particular cholesterol, composition of the envelope...

cell.com
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Great team effort that characterizes the #viral #lipid composition and shows that host #lipidation is required for #SARS-CoV2 infectivity! @Gio_Dangel0 @matteodp @labriataphd @Trono_Lab @EnyaQing @FS_Mesquita @AbramiLaurence
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