The Malmberg Lab studies the functional regulation of natural killer (NK) cells and seeks to employ new insights in NK cell biology in cancer immunotherapy
Oslo, Norway
Joined January 2016
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Great work, congrats. This is where we have to go.
Please check out our paper published in @NatureMedicine on our Phase I trial of AFM13-precomplexed cord blood NK cells in relapsed/refractory CD30+ lymphomas. Led by Dr. Yago Nieto and an outstanding team of coauthors and collaborators, this study marks the first clinical demonstration of NK cell redirection using a bispecific engager. We report an ORR of 92.9% and CR of 66.7% in 42 patients with a median of 7 prior therapies and show that this approach is safe and may serve as a bridge to SCT. Excited to move forward with our next generation engineered NK cells in combination with engagers and mAbs. #CancerResearch #Immunotherapy #NKcells @MDAndersonNews
Incredibly impressing ongoing work in the UK NK community. Thanks for the invitation @mjwsim. Looking forward to discussing more NK and KIR work in the coming days and to the yearly double 🎾 with @DrFran_Colucci
Wow. What an amazing day. So great to see so much great science about my favourite immune cells. Thanks to everyone who came and especially @MalmbergLab for a stellar keynote.
Wow, congrats @PN0rmski. Beautiful work!
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MalmbergLab retweeted
Online Now: Targeting HLA-E-overexpressing cancers with a NKG2A/C switch receptor dlvr.it/TFV5VC
MalmbergLab retweeted
We have an open 2-year postdoc position focusing on computational approaches to identify antigen-specific immune receptors from adaptive immune repertoire data. Application deadline: Nov 6. jobbnorge.no/en/available-jo…
A cell intrinsic NKG2A/C switch receptor to overcome the critical HLA-E checkpoint. Fun collaboration with the Michel Sadelain lab. Michelle Sætersmoen, Ivan Kotchetkov, @LambertoTR @CoE_PRIMA @UniOslo_MED @Oslounivsykehus @CIM_Sweden
Online Now: Targeting HLA-E-overexpressing cancers with a NKG2A/C switch receptor dlvr.it/TFV5VC
MalmbergLab retweeted
Working with a great team including @NathanSinghLab & Stephan Mielke to organize @KeystoneSymp Immune #CellTherapy: Advances in #Cancer and #AutoimmuneDisease
Please join us to explore emerging research in Banff, March 16-19, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scholarship Deadline: December 9, 2024
Short Talk Abstract Deadline: December 9, 2024
Poster Abstract Deadline: February 20, 2025
Early Registration Deadline: January 28
2025keysym.us/KSCellTherapy2… #KSCellTherapy25 pic.x.com/wb3hgSFKGz
keystonesymposia.org/confere…
Very important and much needed funding to establish ATMP Norway, a multi-nodal national infrastructure for cell and gene therapy. Building on investments in GMP laboratories at @Oslounivsykehus and Haukeland University Hospital and a partnership with @UniOslo_MED.
Vi er svært glade for tildelingene fra @forskningsradet i dag, som bla. gir midler til å forsette å jobber med celle-genterapi, samt til forprosjekt for protonterapi.
1,3 milliardar kroner til forskingsinfrastruktur (forskningsradet.no)
MalmbergLab retweeted
GPR56 functions as an upstream checkpoint for migration of highly differentiated NK cells @J_Immunol @MalmbergLab @DanielPal88
doi.org/10.4049/jimmunol.240…
Congrats @DanielPal88. Understanding the migratory behavior of NK cells is critical to overcome one of the major bottlenecks in the field: to make NK cells home to solid tumors. The inhibitory GPR56 axis is one piece of the puzzle.
Finally it's out and I can share with you all the collaborative effort done to produce this paper! Big thanks to @MalmbergLab and all the people who put so much effort into this. journals.aai.org/jimmunol/ar…
MalmbergLab retweeted
Exciting work by @AmirHorowitz and team! Congrats to all.
HLA-E and NKG2A Mediate Resistance to M. bovis BCG Immunotherapy in Non-Muscle-Invasive Bladder Cancer
biorxiv.org/content/10.1101/…
Thanks for this nice and thoughtful commentary of our work. We hope this approach will make a difference in the allogeneic cell therapy space for both T and NK cell based therapies.
Excited to share our commentary on a recent very elegant paper by @MalmbergLab @QuirinHammer and colleagues. A one-way street recognition approach to mediate allogeneic immune cel... sciencedirect.com/science/ar…
MalmbergLab retweeted
Understanding NK cell heterogeneity dlvr.it/T9WTGk
MalmbergLab retweeted
Malmberg and colleagues provide a single-cell transcriptional reference map of healthy human NK cells and use this profile of tumor infiltrating NK cells. Read it here: rdcu.be/dM6V4
nature.com/articles/s41590-0…
MalmbergLab retweeted
Taken together, in this study in @CellStemCell, we demonstrate that modulating the immune synapse can be a promising strategy to avert rejection by the host and hopefully further unlock 🔓 the potential of next-generation allogeneic #Immunotherapy against #cancer
Comprehensive thread highlighting our most recent work now out in @CellStemCell describing a novel approach to increase persistence of allogeneic cell therapy products. Work led by amazing @QuirinHammer and @KarloPerica. @CoE_PRIMA, @Oslounivsykehus @UniOslo_MED @karolinskainst
Happy to share the final work from my post-doc with @MalmbergLab published in @CellStemCell today cell.com/cell-stem-cell/full…
extensive 15-post-🧵 below
MalmbergLab retweeted
Huge congratulations @MalmbergLab and co-authors on this groundbreaking paper! A significant advance for the field #NK #CancerResearch #immunotherapy
Happy to share our new NK cell resource in @NatImmunol: "Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping." nature.com/articles/s41590-0…. @herknet, @AlinePfefferle, @AmirHorowitz @humancellatlas, @CoE_PRIMA, @UniOslo_MED
MalmbergLab retweeted
A landmark paper for the NK cell field, great work, congratulations team!
Happy to share our new NK cell resource in @NatImmunol: "Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping." nature.com/articles/s41590-0…. @herknet, @AlinePfefferle, @AmirHorowitz @humancellatlas, @CoE_PRIMA, @UniOslo_MED
Happy to share our new NK cell resource in @NatImmunol: "Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping." nature.com/articles/s41590-0…. @herknet, @AlinePfefferle, @AmirHorowitz @humancellatlas, @CoE_PRIMA, @UniOslo_MED