We are grateful to @natrevbioeng for highlighting our paper on the cover🎉! Fascinating to see how different 𝐛𝐢𝐨𝐞𝐧𝐠𝐢𝐧𝐞𝐞𝐫𝐢𝐧𝐠 advancements are shaping the 𝐟𝐮𝐭𝐮𝐫𝐞 𝐨𝐟 𝐟𝐨𝐨𝐝: rdcu.be/dqGwT rdcu.be/dqGI7 #CellularAgriculture #MilkBioactive

Honored to be invited as a speaker at the @ukbiotechshow 2026! Many thanks to the organizers for bringing together such an outstanding lineup of clinical leaders, industry executives, regulatory experts, and VC innovators. Looking forward to exchanging perspectives on 𝐧𝐨𝐯𝐞𝐥 𝐭𝐞𝐜𝐡𝐧𝐨𝐥𝐨𝐠𝐢𝐞𝐬, 𝐧𝐞𝐱𝐭-𝐠𝐞𝐧𝐞𝐫𝐚𝐭𝐢𝐨𝐧 𝐢𝐧𝐠𝐫𝐞𝐝𝐢𝐞𝐧𝐭𝐬, 𝐛𝐢𝐨𝐩𝐡𝐚𝐫𝐦𝐚𝐜𝐞𝐮𝐭𝐢𝐜𝐚𝐥 𝐚𝐧𝐝 𝐛𝐢𝐨𝐚𝐜𝐭𝐢𝐯𝐞 𝐦𝐚𝐧𝐮𝐟𝐚𝐜𝐭𝐮𝐫𝐢𝐧𝐠, 𝐚𝐧𝐝 𝐂𝐥𝐢𝐧𝐢𝐜𝐚𝐥 𝐓𝐫𝐢𝐚𝐥𝐬 𝐨𝐟 𝐭𝐡𝐞 𝐅𝐮𝐭𝐮𝐫𝐞 — all contributing to “𝐀𝐜𝐜𝐞𝐥𝐞𝐫𝐚𝐭𝐢𝐧𝐠 𝐭𝐡𝐞 𝐅𝐮𝐭𝐮𝐫𝐞 𝐨𝐟 𝐇𝐞𝐚𝐥𝐭𝐡.” Excited for the inspiring discussions and new collaborations ahead! #LBS2026 #Biotechnology #ClinicalInnovation #FutureOfHealth #PrecisionHealth #TranslationalMedicine

Thank you @SAOscience for highlighting our work and sharing it with your scientific community. We hope this #organoid platform can help advance human-relevant, quantitative models of intestinal epithelial injury and recovery, including epithelial processes relevant to inflammatory bowel disease (#IBD), and support more predictive #translational discovery in gut health and disease. Grateful for the recognition and for bringing this work to a broader audience.

Today, in @CellRepMethods, we report "𝐀 𝐒𝐜𝐚𝐥𝐚𝐛𝐥𝐞 𝐌𝐢𝐜𝐫𝐨𝐚𝐫𝐫𝐚𝐲𝐞𝐝 𝐎𝐫𝐠𝐚𝐧𝐨𝐢𝐝 𝐏𝐥𝐚𝐭𝐟𝐨𝐫𝐦 𝐟𝐨𝐫 𝐏𝐫𝐞𝐜𝐢𝐬𝐢𝐨𝐧 𝐌𝐨𝐝𝐞𝐥𝐢𝐧𝐠 𝐨𝐟 𝐈𝐧𝐭𝐞𝐬𝐭𝐢𝐧𝐚𝐥 𝐄𝐩𝐢𝐭𝐡𝐞𝐥𝐢𝐚𝐥 𝐃𝐚𝐦𝐚𝐠𝐞 𝐚𝐧𝐝 𝐑𝐞𝐜𝐨𝐯𝐞𝐫𝐲." 🔗 Read the paper here: cell.com/cell-reports-method… This work addresses a challenge that has motivated us for several years: 𝐇𝐨𝐰 𝐜𝐚𝐧 𝐰𝐞 𝐬𝐭𝐮𝐝𝐲 𝐧𝐨𝐭 𝐨𝐧𝐥𝐲 𝐢𝐧𝐭𝐞𝐬𝐭𝐢𝐧𝐚𝐥 𝐢𝐧𝐣𝐮𝐫𝐲, 𝐛𝐮𝐭 𝐚𝐥𝐬𝐨 𝐭𝐡𝐞 𝐝𝐲𝐧𝐚𝐦𝐢𝐜𝐬 𝐨𝐟 𝐡𝐞𝐚𝐥𝐢𝐧𝐠 𝐚𝐧𝐝 𝐫𝐞𝐜𝐨𝐯𝐞𝐫𝐲 𝐢𝐧 𝐚 𝐡𝐮𝐦𝐚𝐧-𝐫𝐞𝐥𝐞𝐯𝐚𝐧𝐭 𝐬𝐲𝐬𝐭𝐞𝐦 — 𝐚𝐭 𝐬𝐜𝐚𝐥𝐞 𝐚𝐧𝐝 𝐚𝐭 𝐬𝐢𝐧𝐠𝐥𝐞-𝐨𝐫𝐠𝐚𝐧𝐨𝐢𝐝 𝐫𝐞𝐬𝐨𝐥𝐮𝐭𝐢𝐨𝐧? A key part of the work was the development of the 𝐈𝐧𝐭𝐞𝐬𝐭𝐢𝐧𝐚𝐥 𝐎𝐫𝐠𝐚𝐧𝐨𝐢𝐝 𝐑𝐞𝐜𝐨𝐯𝐞𝐫𝐲 𝐒𝐜𝐨𝐫𝐞 (𝐈𝐎𝐑𝐒) — an integrated, time-resolved metric that captures the injury–recovery trajectory of individual organoids rather than relying on a single endpoint measurement. 🔬𝐒𝐨𝐦𝐞 𝐨𝐟 𝐭𝐡𝐞 𝐟𝐢𝐧𝐝𝐢𝐧𝐠𝐬 𝐈 𝐚𝐦 𝐩𝐚𝐫𝐭𝐢𝐜𝐮𝐥𝐚𝐫𝐥𝐲 𝐞𝐱𝐜𝐢𝐭𝐞𝐝 𝐚𝐛𝐨𝐮𝐭: ✅ We established a controlled cytokine-induced epithelial injury model and showed that its inflammatory transcriptional programs overlap with signatures observed in 𝐚𝐜𝐭𝐢𝐯𝐞 𝐂𝐫𝐨𝐡𝐧’𝐬 𝐝𝐢𝐬𝐞𝐚𝐬𝐞 𝐛𝐢𝐨𝐩𝐬𝐢𝐞𝐬. ✅ We demonstrated that epithelial injury and recovery can be 𝐪𝐮𝐚𝐧𝐭𝐢𝐟𝐢𝐞𝐝 𝐝𝐲𝐧𝐚𝐦𝐢𝐜𝐚𝐥𝐥𝐲 𝐚𝐧𝐝 𝐚𝐭 𝐡𝐢𝐠𝐡 𝐭𝐡𝐫𝐨𝐮𝐠𝐡𝐩𝐮𝐭, providing a framework for identifying responder phenotypes and evaluating intervention timing. ✅ Using the platform for bioactive screening, we identified 𝐍𝐢𝐜𝐨𝐭𝐢𝐧𝐚𝐦𝐢𝐝𝐞 (𝐍𝐀𝐌) and β-𝐡𝐲𝐝𝐫𝐨𝐱𝐲𝐛𝐮𝐭𝐲𝐫𝐚𝐭𝐞 (𝐁𝐇𝐁), a ketone body, as promising candidates supporting epithelial recovery, with NAM showing effects associated with epithelial barrier maintenance and metabolic homeostasis. 🙏 I am deeply grateful to 𝐀𝐥𝐢𝐧𝐞 𝐑𝐨𝐜𝐡, 𝐌𝐚𝐫𝐢𝐧𝐞 𝐌𝐞𝐲𝐞𝐫, 𝐉𝐮𝐥𝐢𝐚𝐧𝐞 𝐃𝐞𝐫𝐯𝐚𝐮𝐱, and 𝐋𝐚𝐮𝐫𝐞𝐧𝐭 𝐅𝐞𝐫𝐫𝐢𝐞𝐫 for their exceptional scientific contributions and leadership throughout this study. I am also particularly grateful to have co-led this work with 𝐍𝐚𝐭𝐡𝐚𝐥𝐢𝐞 𝐁𝐫𝐚𝐧𝐝𝐞𝐧𝐛𝐞𝐫𝐠 and 𝐌𝐚𝐫𝐢𝐨 𝐍𝐨𝐭𝐢. Their scientific leadership, partnership, and vision were instrumental in shaping this research and bringing it to completion. This work reflects a truly interdisciplinary collaboration across @Nestlé 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 & 𝐃𝐞𝐯𝐞𝐥𝐨𝐩𝐦𝐞𝐧𝐭, 𝐃𝐎𝐏𝐏𝐋 𝐒.𝐀., and 𝐍𝐞𝐱𝐜𝐨 𝐀𝐧𝐚𝐥𝐲𝐭𝐢𝐜𝐬, bringing together expertise spanning organoid biology, bioengineering, imaging, data science, and translational research. #Organoids #GutHealth #IntestinalBiology #Bioengineering #MachineLearning #AI #PrecisionNutrition #TranslationalResearch #NewApproachMethodologies

𝐎𝐮𝐫 𝐍𝐞𝐰 𝐏𝐮𝐛𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐢𝐬 𝐎𝐮𝐭! Thrilled to share our latest paper published in Nature @CommsBio: "𝐋𝐚𝐜𝐭𝐨𝐟𝐞𝐫𝐫𝐢𝐧-𝐎𝐬𝐭𝐞𝐨𝐩𝐨𝐧𝐭𝐢𝐧 𝐂𝐨𝐦𝐩𝐥𝐞𝐱𝐞𝐬: 𝐈𝐧𝐬𝐢𝐠𝐡𝐭𝐬 𝐢𝐧𝐭𝐨 𝐈𝐧𝐭𝐞𝐬𝐭𝐢𝐧𝐚𝐥 𝐎𝐫𝐠𝐚𝐧𝐨𝐢𝐝 𝐁𝐢𝐨𝐚𝐯𝐚𝐢𝐥𝐚𝐛𝐢𝐥𝐢𝐭𝐲 𝐚𝐧𝐝 𝐆𝐮𝐭 𝐌𝐢𝐜𝐫𝐨𝐛𝐢𝐨𝐭𝐚 𝐌𝐨𝐝𝐮𝐥𝐚𝐭𝐢𝐨𝐧" 👉 Read the full manuscript here: rdcu.be/evkf9 This work is the result of a fantastic interdisciplinary collaboration among leading scientists from @Nestle 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 & 𝐃𝐞𝐯𝐞𝐥𝐨𝐩𝐦𝐞𝐧𝐭, 𝐃𝐨𝐩𝐩𝐥 𝐒𝐀, & 𝐂𝐫𝐲𝐩𝐭𝐨𝐛𝐢𝐨𝐭𝐢𝐱. 🙏 My deepest appreciation goes to the leading experts for their exceptional leadership and contributions to this study: 𝐂𝐚𝐦𝐢𝐥𝐥𝐚 𝐂𝐞𝐫𝐨𝐧𝐢, 𝐋𝐨ï𝐜 𝐃𝐚𝐲𝐨𝐧, 𝐏𝐢𝐞𝐭𝐞𝐫 𝐕𝐚𝐧 𝐝𝐞𝐧 𝐀𝐛𝐛𝐞𝐞𝐥𝐞, 𝐚𝐧𝐝 𝐀𝐥𝐢𝐧𝐞 𝐑𝐨𝐜𝐡. Also, huge thanks for the invaluable contribution of 𝐉𝐮𝐥𝐢𝐚𝐧𝐞 𝐃𝐞𝐫𝐯𝐚𝐮𝐱, 𝐌𝐚𝐫𝐢𝐨𝐧 𝐄𝐫𝐧𝐞𝐬𝐭, 𝐏𝐚𝐬𝐜𝐚𝐥𝐢𝐧𝐞 𝐒𝐢𝐫𝐮𝐠𝐮𝐞, 𝐀𝐮𝐫é𝐥𝐢𝐞𝐧 𝐁𝐚𝐮𝐝𝐨𝐭, 𝐌𝐚𝐫𝐢𝐧𝐞 𝐊𝐫𝐚𝐮𝐬, 𝐍𝐚𝐭𝐡𝐚𝐥𝐢𝐞 𝐁𝐫𝐚𝐧𝐝𝐞𝐧𝐛𝐞𝐫𝐠, and 𝐉𝐨𝐧𝐚𝐭𝐡𝐚𝐧 𝐎'𝐑𝐞𝐠𝐚𝐧. Your expertise, insights, and teamwork made this possible. Special thanks to 𝐃𝐚𝐯𝐢𝐝 𝐆𝐨𝐮𝐥𝐝𝐢𝐧𝐠: It was a true privilege to co-lead this work alongside you. 🔬 𝐊𝐞𝐲 𝐓𝐚𝐤𝐞𝐚𝐰𝐚𝐲𝐬 ✅ Milk protein bioactives and their complex forms were well absorbed by microarrayed 3D apical-out intestinal organoid platform, with no toxicity observed. ✅ In an ex vivo infant gut microbiota model (SIFR® technology), these complexes boosted the production of health-promoting gut metabolites like butyrate. ✅ Bioactives positively modulated the gut microbial community, enriching beneficial species such as 𝘉𝘢𝘤𝘵𝘦𝘳𝘰𝘪𝘥𝘦𝘴 𝘧𝘳𝘢𝘨𝘪𝘭𝘪𝘴 and 𝘊𝘭𝘰𝘴𝘵𝘳𝘪𝘥𝘪𝘶𝘮 𝘴𝘺𝘮𝘣𝘪𝘰𝘴𝘶𝘮. 🚀 Why this matters: By combining i) 𝐚𝐝𝐯𝐚𝐧𝐜𝐞𝐝 𝐨𝐫𝐠𝐚𝐧𝐨𝐢𝐝 𝐦𝐨𝐝𝐞𝐥𝐬 with ii) 𝐟𝐮𝐧𝐜𝐭𝐢𝐨𝐧𝐚𝐥 𝐞𝐱 𝐯𝐢𝐯𝐨 𝐦𝐢𝐜𝐫𝐨𝐛𝐢𝐨𝐭𝐚 𝐚𝐬𝐬𝐞𝐬𝐬𝐦𝐞𝐧𝐭 and iii) 𝐦𝐮𝐥𝐭𝐢-𝐨𝐦𝐢𝐜𝐬 𝐚𝐧𝐚𝐥𝐲𝐬𝐞𝐬, this platform sets a strong precedent for New Approach Methodologies (NAMs). We propose that this "𝐈𝐧𝐭𝐞𝐠𝐫𝐚𝐭𝐞𝐝 𝐀𝐩𝐩𝐫𝐨𝐚𝐜𝐡" offers a robust, human-relevant framework that enhances the translatability of preclinical findings by generating comprehensive mechanistic, safety, and efficacy data. Heartfelt thanks to all 𝐜𝐨𝐥𝐥𝐚𝐛𝐨𝐫𝐚𝐭𝐨𝐫𝐬, 𝐦𝐞𝐧𝐭𝐨𝐫𝐬, 𝐩𝐚𝐫𝐭𝐧𝐞𝐫𝐬, 𝐞𝐝𝐢𝐭𝐨𝐫𝐬, 𝐚𝐧𝐝 𝐫𝐞𝐯𝐢𝐞𝐰𝐞𝐫𝐬 who contributed to this journey. Looking forward to the next steps in science-driven health innovation! #Organoids #Microbiota #FoodTech #NAMs #NutritionScience #GutHealth #InVitroModels #ExVivoResearch #TranslationalScience

Looking forward to and excited about speaking at next year's Future Labs Live in Basel! Thanks, @FutureLabs_Live for the invitation 🙏

Thank you, @BioTechX_, for the invitation - It would be an honor to chair the "Analytics Platform" session with an exceptional lineup of industry-leading speakers and executives in Basel, Switzerland. Check out our agenda here 👉🏻 lnkd.in/eXM7cReP

Thanks, @NaturePortfolio for the highlight of our work @natrevbioeng🙏! Kudos to our co-first authors, @LucileYart & @AndyWiraWijaya. ➡️rdcu.be/dn5TN @Nestle

Thanks @isaaa_org for the highlight 🙏🏽 😊 - “Researchers Review Milk Bioactive Production Using Cellular Agriculture”isaaa.org/kc/cropbiotechupda… #cellularagriculture #bioactive #milk ➡️ Link to the paper @natrevbioeng : rdcu.be/dn5TN @GoodFoodInst @cellagritech