Roche Institute for Human Biology. @IHB_Research
Basel
Joined June 2018
- Tweets301
- Following1K
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Joep Beumer retweeted
This is the person to whom @UAntwerpen, @ugent, and @VUBrussel awarded an honorary doctorate.
Not only does she advocate boycotting the lone democracy in the Middle East, surrounded by groups that want to wipe it off the map; she also opposes military support for Ukraine, that other existentially threatened liberal democracy today: “I agree with those who think that we need to stop sending weapons to Ukraine.”
She never found a war she didn’t end up on the wrong side of. Congratulations, Flemish universities.
Festival di Open 2026, Albanese: «Sono d'accordo con chi pensa che bisogna smettere di inviare armi a Kiev» - Il video open.online/2026/09/20/festi…
Joep Beumer retweeted
The GLP-1 drugs have evidence for beneficial impact— heart, kidney, liver, joints, immune system, and brain—that are independent of weight loss
@Cell_Metabolism @DanielJDrucker
cell.com/cell-metabolism/abs…
Huge congrats to the talented @NinoukAkkerman who drove the development of this organoid model of the human adrenal cortex. Accompanied by a great perspective by Pierre Val: cell.com/cell-stem-cell/full…
Ninouk drafted this beautiful cover that was selected by the editorial team!
Online now! An organoid model of the human adrenal cortex identifies drivers of steroidogenesis and zonation. A study by @BeumerJoep & colleagues in @cellpressblue #ISSCR2026 hubs.li/Q04p2XRr0
While being able to expand for more than a year, these organoids recapitulate the key function of this endocrine organ by producing all of its steroid hormones, including cortisol and aldosterone.
In collaboration with Quan Xu and @GrayCampLab , we used this model combined with spatial transcriptomics to establish a key role for WNT, ACTH and BMP in regulating functional zonation.
Great opportunity to join a fantastic lab at @IHB_Research !
We are searching for computational PhDs and Postdocs to join our group in collaboration with @TreutleinLab . We have exciting single-cell technology projects that incorporate bioengineering, computation, biology, translation. Send CV to [email protected]
Joep Beumer retweeted
Thank you everyone for the congratulations and the large number of applications! I want to specifically encourage applications for these positions:
* Postdoc in structural biology (cryoEM, ideally with X-ray too)
* Full time lab manager/technician with wetlab experience
Joep Beumer retweeted
Diet/microbes place the gut epithelium as a nexus for evolutionary change. With @TheSpenceLab @genomeCraig, we use #organoids to explore how evolution prepared the developing human intestine for exposure to the environment. @ScienceMagazine #evodevo 🧵1/11 science.org/doi/10.1126/scie…
Joep Beumer retweeted
Thrilled to see #SAVANA out in @naturemethods🥳 SAVANA detects haplotype-resolved somatic SVs and copy number aberrations (SCNAs) and infers tumour purity & ploidy in clinical samples using long-read sequencing with or WITHOUT a matched germline control 👇nature.com/articles/s41592-0…
Joep Beumer retweeted
Modular integration of epithelial, microbial, and immune components to study human intestinal biology. Amazing team project with @_RubenL_, Marius Harter, @CY_Qianhui_YU, @mike_nikolaev, @TheLutolfLab, Nikolche Gjorevski, and many others @IHB_Research biorxiv.org/content/10.1101/…
Joep Beumer retweeted
New insights into the actions of GIP agonism vs. antagonism on food intake and body weight in mice from Timo Muller and colleagues #weightloss #obesity @NatMetabolism @TimoMueller_IDO @MatthiasTschop
nature.com/articles/s42255-0…
We are searching for 2 talented MSc students to join the group! If you are interested in using advanced organoid models to study regulators of intestinal differentiation or nutrient uptake, please apply! go.roche.com/skt2b and go.roche.com/wf7hj
@IHB_Research
Joep Beumer retweeted
A new peptide, BRINP2-related peptide (BRP) administered pharmacologically, reduces food intake and exhibits anti-obesity effects in mice and pigs without inducing nausea or aversion.
nature.com/articles/s41586-0…
Great pleasure to host @SItzkovitz at @IHB_Research. Exciting talk & discussions on spatial transcriptomics of adult tissues. Including promising translational applications of using shed intestinal cells for longitudinal profiling of homeostatic and diseased cell states!
A big thanks to @SItzkovitz of @WeizmannScience visiting #TeamIHB! We were fascinated to learn how spatial and shed cell transcriptomics of the human digestive tract can illuminate how single cells in mammalian tissues collectively achieve physiological goals.
ALT Dr Shalev Itzkovitz stands at the podium. Behind him, the presentation shows 37-plex CODEX yielded 226,529 cells classified to 18 main cell-types
Joep Beumer retweeted
We are searching for a Master's Student/Intern to join the group for 6-12 months to work on large-scale bioimage analysis of complex human model system data!
Please send your CV to: [email protected] #IHB
Joep Beumer retweeted
Our first 2025 paper!
We discuss in @NatRevMCB how epithelial stem cells mechanically sculpt tissues, and how these forces are altered in cancer.
Great work from our former and current tumor mechanobiology experts Vince Fiore & @almagro_jorge
nature.com/articles/s41580-0…
Joep Beumer retweeted
iFlpMosaics are now published @naturemethods. A compendium of novel genetic tools and related methods for inducing and analysing genetic mosaics in a high-throughput manner. nature.com/articles/s41592-0… Tweetorial 👇
Joep Beumer retweeted
We updated our BindCraft preprint with lots of new exciting results! We release all our binder sequences and models, include more in silico analysis, novel design targets, and present AAV retargeting to specific cell types using de novo binders!
biorxiv.org/content/10.1101/…
Joep Beumer retweeted
If you really love your protein of interest commit to a tattoo @ardemp
Joep Beumer retweeted
📢We are hiring a postdoctoral researcher 📢
Are your curious about the mechanisms driving metastatic spread? Do you have *bioinformatics* skills to help us unravel these mechanisms?
We (@Bergerslab, @ColindaScheele) may have your dream job @VIB_CCB!
jobso.id/k7cp