@JussherLab

Proud father, loving husband, enthusiastic scientist, Detroit Red Wings & Lions diehard, trekkie/space lover, casual Madden player and Game of Thrones Fanatic

Joined March 2015
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This will likely be my last thread here as I’m moving over to Bluesky (bsky.app/profile/jussherlab.…), but wanted to share exciting work from former PDF @Amurtab @UAlberta_Pharm ; cell.com/iscience/pdf/S2589-…
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6) So grateful to all @Amurtab hard work and to our many collaborators who helped this paper happen , but a special shoutout to Dr. Dion Brocks @UAlberta_Pharm , whose lab developed the assay for us to detect/measure PSSI-51 in biological specimens
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7) For anyone interested in using PSSI-51 as a tool to manipulate #ketone #metabolism #oxidation for their studies, we are happy to share and please just reach out to myself or @Amurtab
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This is a very difficult msg for me to type, but it is with deep sadness that I share news regarding the passing of Dr. Gary Lopaschuk, who was not only my mentor, but a dear friend these past 20 years. pediatrics.cmail20.com/t/d-e…
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I cannot articulate in the form it truly deserves how much he has impacted my life, but I know I would not be who I am today, or where I am today, if not for him, which I know extends to many others here at the UofA
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Our LinkedIn page is now live! Give us a follow to stay up to date with all things SHVM 2025 and beyond #longlivemetabolism #SHVM 👇 linkedin.com/company/shvm

Society for Heart and Vascular Metabolism (SHVM) | LinkedIn

Society for Heart and Vascular Metabolism (SHVM) | 267 followers on LinkedIn. 23rd Annual Scientific Sessions: Aging as a gateway to cardiovascular-metabolic research | 26-29 October 2026 Osaka, Japan

linkedin.com
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Stay tuned for further updates as we near the 22nd Annual SHVM meeting: Shedding Light on Emerging Metabolic Targets in Cardiovascular Diseases 🫀 Abstract submission 17 March 2025 Early bird registration 18 April 2025 Registration and payment deadline 15 May 2025
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A big CONGRATS to @JordanSFChan , who successfully passed his #CandidacyExam this morning! Really proud seeing how much he has matured as a #scientist since joining the lab May 2021
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I'm looking to hire a fully funded PhD student this year. If you are interested in investigating mitochondrial bioenergetics in diverse tissues please reach out.
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Excited to share my work with @DanielJDrucker on the role for GIPR agonism alone and with GLP-1R agonism (@tirzepatide_ ) in the regulation of gut inflammation, and providing new insights on the localization of the GIP receptor in the gut. See paper here: insight.jci.org/articles/vie…
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Finally the latest baby of the Quebec PAH and vascular biology research group is out 😎. Congrats Dr Grobs @Grobs4 @3CPRCouncil @PVRI @ATS_PC @PullamsettiL @Savai_Lab @facmedUL science.org/doi/10.1126/scit…

ATP citrate lyase drives vascular remodeling in systemic and pulmonary vascular diseases through...

ATP-citrate lyase is a target for therapeutic interventions in pulmonary hypertension and coronary artery disease.

science.org
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Using multiple techniques the authors affirm that Gfral expression is overwhelmingly restricted to the brainstem in healthy mice @MolMetab @cusm_muhc @seeleyrj sciencedirect.com/science/ar…
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Check our last review in the special issue of Essays in Biochemistry on AMPK and AMPK-related kinase👉AMPK and O-GlcNAcylation: interplay in cardiac pathologies and heart failure portlandpress.com/essaysbioc… @ISHR_ES @escardio @GRRC_SFCardio

AMPK and O-GlcNAcylation: interplay in cardiac pathologies and heart failure

Abstract. Heart failure (HF) represents a multifaceted clinical syndrome characterized by the heart’s inability to pump blood efficiently to meet the body’s metabolic demands. Despite advances in...

portlandpress.com
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The SUMMIT trial Tirzepatide for #HeartFailure with Preserved Ejection Fraction in PPL with #Obesity A lower risk of a composite of death from cardiovascular causes or worsening heart failure nejm.org/doi/full/10.1056/NE…

Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity | NEJM

Obesity increases the risk of heart failure with preserved ejection fraction. Tirzepatide, a long-acting agonist of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor...

nejm.org
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On #WorldDiabetesDay2024 congratulations to Professor Erin Mulvihill @HeartInstitute @OttawaU @uOttawaBMI @CIHR_IRSC this years receipient of the early career investigator award from @DiabetesCanada Felicitations! #diabetes
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