@Savai_Lab

Institute for Lung Health- ILH Group of Prof.Dr.Rajkumar Savai working on #Lungcancer & #TumorMicroenvironment specialized on #macrophages

 Bad Nauheim, Deutschland
Joined March 2020
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  • Following240
  • Followers399
54Media
✨ We want to congratulate our @oznuraktaycetin for her successful PhD defense!! Very proud of you and looking forward to more great success!! 🔬🫁🥳
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@r_savai @PullamsettiL @mpi_hlr #DZL #CRC1213 #UGMLC @CPI_ExStra @dzlacademy #Macrophage #LungCancer #TumorMicroenvironment
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🚨Excited to share our latest study in Cell Metabolism! By combining spatial metabolomics with multi-omics analyses, we identified the IRG1/itaconate–G6PD axis as a promising therapeutic target in lung cancer 🫁🧬 Great work of @siavash668 👏👏 doi.org/10.1016/j.cmet.2026.…
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@r_savai @PullamsettiL @mpi_hlr #DZL #CRC1213 #UGMLC @CPI_ExStra @dzlacademy #Macrophage #LungCancer #TumorMicroenvironment
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Congratulations to @SarodePoonam and @SBarboutsi for winning the poster prizes last week in the #CPI2.0 conference!! Very proud of your hard work! 🫁🧬🧫✨
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@PullamsettiL @mpi_hlr #DZL #CRC1213 #UGMLC @CPI_ExStra @dzlacademy #Macrophage #LungCancer #TumorMicroenvironment
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Great CPI2.0 retreat in Bad Nauheim! Happy to introduce our spatial omics in transcriptomics, proteomics and metabolomics with the community! 🫁🔬@r_savai
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@PullamsettiL @mpi_hlr #DZL #CRC1213 #UGMLC @CPI_ExStra @dzlacademy #Macrophage #LungCancer #TumorMicroenvironment
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🚨New paper alert: Lung cancer is more than just tumor cells. Our new review highlights how the TME changes over time, causing resistance and influencing therapy response-an important step toward more effective treatment strategies🫁🔬 doi.org/10.1016/j.semcancer.… @selma_diz @r_savai
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@PullamsettiL @mpi_hlr #DZL #CRC1213 #UGMLC @CPI_ExStra @dzlacademy #LungCancer #TumorMicroenvironment
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🚨 Check out our latest editorial in #AJRCCM highlighting how hypoxic niches, anatomy, and microenvironment drive EGFR-mutant lung adenocarcinoma beyond mutations & discussing the use of spatial omics & AI to understand the dynamic ecosystem: doi.org/10.1093/ajrccm/aamag…

Spatial niches shape early oncogene-driven lung cancer: anatomy as destiny

The early development of lung adenocarcinoma (LUAD) has traditionally been framed through a genetic lens, with oncogenic drivers such as epidermal growth f

academic.oup.com
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@siavash668 @r_savai @PullamsettiL @mpi_hlr #DZL #CRC1213 #UGMLC @CPI_ExStra @dzlacademy #LungCancer #TumorMicroenvironment
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We would like to congratulate our Dr. Ayoson for defending his PhD brilliantly!! We are very proud of you! 👏👏 🫁🔬🧫 @ayoson_joshua! @MbmlProgram
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New paper alert 🚨: Same cancer, different immune worlds: CD45⁺ landscapes in lung tumors split into inflammatory suppression and metabolic rewiring, opening model-specific avenues for immunotherapy frontiersin.org/journals/imm… @selma_diz @r_savai

Frontiers | Divergent CD45+ immune landscapes shape the lung tumor microenvironment

BackgroundThe lung tumor microenvironment (TME) plays a crucial role in the progression and metastasis of lung cancer. It consists of various cell types that...

frontiersin.org
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@PullamsettiL @mpi_hlr #DZL #CRC1213 #UGMLC @CPI_ExStra @dzlacademy #Macrophage #LungCancer #TumorMicroenvironment
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Happy to share that our lab received two Von Behring-Röntgen-Stiftung grants! Dr. Karger will study immune cell energy metabolism in lung cancer, and in collaboration with Prof. Bartsch, we’ll explore ADAM8’s role in LC. Looking forward to exciting new research ahead! 🫁🔬
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br-stiftung.de/aktuelles/det… @r_savai @UKGM_Presse #UKGM #ILH #DZL #TME #LungCancer

1,9 Millionen Euro für medizinische Spitzenforschung

br-stiftung.de
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Highlights the role of epi-transcriptomics in lung response to low oxygen offering new angles for anti-inflammatory therapies! Thanks to the amazing team! @jlugiessen @CPI_ExStra @chansteve73 @KeYuan_BCH @Savai_Lab @dzlacademy
Pullamsetti Lab@PullamsettiL5 Nov 2025
🆕 Just out in Circulation Research! We reveal how the RNA-editing enzyme ADAR1 shields lung blood vessels from auto-inflammatory damage in pulmonary hypertension. ahajournals.org/doi/10.1161/…

Deficiency of Smooth Muscle Adar1 Exacerbates Vascular Remodeling and Pulmonary Hypertension |...

BACKGROUND: ADAR1 (adenosine deaminase acting on RNA 1) catalyzes the conversion of adenosine to inosine in double stranded RNAs (dsRNAs), which is critical to prevent autoinflammatory responses...

ahajournals.org
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Excellent exchange between the Institute for Lung Health and the Institut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval. Cheers to a new chapter filled with collaborations and teamwork!! @r_savai @sbonnet2 @PullamsettiL
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#LungCancer #TumorMicroenvironment @mpi_hlr #DZL #CRC1213 #UGMLC @CPI_ExStra @dzlacademy
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