@JordanSFChan

4th Year PhD Candidate @JussherLab @UAlberta - Faculty of Pharmacy and Pharmaceutical Sciences

 Edmonton, Alberta
Joined April 2022
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  • Following178
  • Followers99
11Media
If you’re looking for an Assistant Professor position, in immunology, metabolism, and aging- come join us in Madison! The metabolism community is outstanding and spans the entire campus. jobs.wisc.edu/jobs/immunolog…
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Cardiac PGC1a is required for adaptations of the heart to exercise (in mice). A wonderful collaboration with the lab of Tony Rosenzweig. Sumeet is off to start his won lab at UVa (congrats!) nature.com/articles/s44161-0…
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The passing Of Dave Mangelsdorf is a terrible loss for his family, friends and the science world. Davo will never be forgotten. 😢 chapelgazette.cfd/david-mang…
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Central glucagon-like peptide 1 receptor activation inhibits Toll-like receptor agonist-induced inflammation. Read the full study by @DanielJDrucker & colleagues in @Cell_Metabolism #ENDO2025 hubs.li/Q03wtMFK0

Central glucagon-like peptide 1 receptor activation inhibits Toll-like receptor agonist-induced...

GLP-1R agonists may reduce cardiometabolic complications in part through reduction of inflammation. Here we show, using pharmacology and genetics, that the anti-inflammatory actions of GLP-1RAs to...

cell.com
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RESEARCH | @LoganTownsend86, @DrGregSteinberg et. al. (@MacMODR) #Anxiety -like behaviour in mice, as a result of psychological #stress, is shown to be mediated by #GDF15 release in response to adipose tissue #lipolysis 🐭 nature.com/articles/s42255-0…

GDF15 links adipose tissue lipolysis with anxiety

Nature Metabolism - Anxiety-like behaviour in mice, as a result of psychological stress, is shown to be mediated by GDF15 release in response to adipose tissue lipolysis.

nature.com
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Replying to @KaitDennis19
@KaitDennis19 et al found #FoxO1-zDHHC4-#CD36 S-acylation axis drives metabolic dysfunction in #diabetes. Learn more at ahajrnls.org/3Zpvc0g @heatherlab.bsky.social @heather_ox @JussherLab @FullerLabGlas @dunjaaks @MarcosCG_95 @ujangpurnama
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🚨New from our group in @CircRes We identify a FoxO1-zDHHC4-CD36 S-acylation axis driving metabolic + contractile dysfunction in the diabetic heart. Blocking this pathway reprograms FA metabolism and improves heart function. Read more: 🔗 ahajournals.org/doi/full/10.…

FoxO1-zDHHC4-CD36 S-Acylation Axis Drives Metabolic Dysfunction in Diabetes | Circulation Research

BACKGROUND: The fatty acid (FA) transporter CD36 (FA translocase/cluster of differentiation 36) is the gatekeeper of cardiac FA metabolism. Preferential localisation of CD36 to the sarcolemma is one...

ahajournals.org
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Same spot, 3 days later, after an amazing conference and…a best ECI presentation award! Thank you again @ishr2025 @QKarwi for the opportunity to present some of my research in the @JussherLab. Had a great time reconnecting with old colleagues and getting to meet some new ones!
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Thank you to @ISHR_ECI @QKarwi for giving me the opportunity to present some of my research at the #ISHR2025 ECI Symposium today in Nara, Japan!!
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Grateful to @JussherLab Jordan SF Chan & @AmDiabetesAssn for featuring our T2D cardiomyopathy model in their editorial.Of Mice and Men: Toward a Better Model of Diabetic Cardiomyopathy With Application in Female Animals diabetesjournals.org/diabete… @QMULWHRI @wellcometrust
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Here it is proposed that halofuginone, a FDA–approved anti-scleroderma and antiprotozoal drug, is a promising anti-#obesity agent acting via FGF-21 and GDF-15 in preclinical mouse and pig models @ScienceAdvances #weightloss science.org/doi/10.1126/scia…

The clinical antiprotozoal drug halofuginone promotes weight loss by elevating GDF15 and FGF21

Halofuginone curbs weight gain in mice and pigs.

science.org
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Thank you for going easy on me 🙏
John R. Ussher@JussherLab16 Jan 2025
A big CONGRATS to @JordanSFChan , who successfully passed his #CandidacyExam this morning! Really proud seeing how much he has matured as a #scientist since joining the lab May 2021
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So this Monday was the 10 year #anniversary of the lab (time flies!!) and a very eventful week, starting with a presentation on #GLP1 receptor agonists and #cardiovascular #outcomes at the fantastic @MacMODR Annual Research Symposium
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Happy for my labmatte @Amurtab Congratulations 👏 🎉 you worked hard and you deserve it!
John R. Ussher@JussherLab8 Nov 2024
Replying to @JussherLab
And to top it off now that it’s official, super excited to see my #postdoc @Amurtab join @UAlberta_Pharm as a new #AssistantProfessor starting Jan 2025. It’s been nearly 5 years seeing Amir pour his heart and soul into his #drugdiscovery research and so excited for his future!
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New anti-obesity drug shows promise in preventing heart failure related to Type 2 diabetes. John Ussher finds experimental weight loss drug GDF15 improves heart function in mice with diabetes, independent of its weight loss effects. @JussherLab ualberta.ca/en/folio/2024/10…
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It’s been an incredible journey completing my PhD at @JussherLab . Excited to start my postdoc at @DrGregSteinberg lab! I wasn’t expecting this but I’m honored to receive #CIHR Postdoctoral Fellowship. Thanks to @CIHR_IRSC for this opportunity. Looking forward to the new chapter
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Jordan Chan retweeted
Qutuba G Karwi@QKarwi30 Aug 2024
🎉Excited to share our new review @mole_biochem discussing how energy metabolism controls the inflammatory responses and functional phenotypes of #Macrophage in #Cardiometabolic_Diseases #Obesity #Diabetes #Atherosclerosis #HFrEF #HFpEF @BioMedMUN @MUNMed rdcu.be/dSiVI
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🥇🎉🥇 Congratulations to @JussherLab, the winner of our 2024 #MidCareerResearcher prize! Ussher's review will focus on the Multifaceted Roles of Ketones in Physiology!
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Read the latest review in the #Incretins Special Collection: 📍 Incretin-mediated control of cardiac energy metabolism By @JordanSFChan, @Taninshf and @JussherLab @UAlberta_Pharm 👉 ow.ly/e4sx50SXq5X
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Jordan Chan retweeted
Janice Kung@janicekung13 Aug 2024
ICYMI: New article by @JussherLab Growth differentiation factor 15 alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy pubmed.ncbi.nlm.nih.gov/3909… @UAlberta_Pharm

Growth differentiation factor 15 alleviates diastolic dysfunction in mice with experimental...

Growth differentiation factor 15 (GDF15) is a peptide with utility in obesity, as it decreases appetite and promotes weight loss. Because obesity increases the risk for type 2 diabetes (T2D) and...

pubmed.ncbi.nlm.nih.gov
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