@GulerLab

Students of food, time and dopamine... @uvabio @UVA_PFN @AliDGuler

 C'ville
uva.theopenscholar.com/ali-guler
Joined July 2019
  • Tweets258
  • Following86
  • Followers234
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Our new preprint: We found a hunger rheostat. Two molecular switches (TrkB & p75NTR) let neurons dial appetite up or down depending on whether you're starving or feasting. fun collab with @GulerLab biorxiv.org/content/10.1101/…

BDNF receptor balance gates AgRP-to-PVH fiber density and stimulation-evoked feeding across caloric...

Agouti-related peptide (AgRP) neurons show opposite pairings of anatomy and output across caloric states. In mice, 24-h caloric restriction (CR) increases AgRP-to-paraventricular hypothalamus (PVH)...

biorxiv.org
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At UVA, you’ll be part of a vibrant, collaborative neuroscience community spanning Biology, Medicine, Engineering, Data Science & more… in beautiful Charlottesville, VA. Apply today & help shape the future of neuroscience: apply.interfolio.com/172892 #Biology #UVA
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We welcome applicants working on: • Neural circuits & plasticity • Glia & brain interactions • Behavioral genetics & genomics …and more! Join a highly interdisciplinary dept with access to state-of-the-art imaging, genomics, metabolomics, and computing resources. #NeuroJobs
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We’re hiring! @uvabio @UVA_PFN @UVA UVA Biology is recruiting multiple tenure-track Assistant Professors in neuroscience as part of a $75M Brain & Neuroscience Initiative. Apply by Oct 15, 2025. Start Aug 2026. apply.interfolio.com/172892 #Neuroscience #FacultyJobs
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Happy Glp1rS33W day, December 18th!
Ali D. Güler@AliDGuler18 Dec 2024
Replying to @AliDGuler
It turns out today is the humanized "Glp1rS33W" rodent model day. Here is another one published today by Eli Lilly and Company @EliLillyandCo science.org/doi/10.1126/scit… Didn't know... we could have had a party 😉🥳🎉

The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron

Studies reveal pharmacological characteristics for activating the GLP-1 receptor with a nonpeptide agonist.

science.org
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It turns out today is the humanized "Glp1rS33W" rodent model day. Here is another one published today by Eli Lilly and Company @EliLillyandCo science.org/doi/10.1126/scit… Didn't know... we could have had a party 😉🥳🎉

The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron

Studies reveal pharmacological characteristics for activating the GLP-1 receptor with a nonpeptide agonist.

science.org
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Our collaborative team at UVA Biology Department @uvabio including the labs of Chris Deppmann @deppmann and John Campbell @AUGCsoup are awesome. They all made it fun!
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You can read more about it here: biorxiv.org/content/10.1101/… Send us feedback on how we can improve our manuscript. All this work was led by three very talented graduate students: Lizzie Godschall @LizzieGodschall, Buğra Güngül @bugragungul and Isabelle Sajonia @isabellesajonia. 15/

A Brain Reward Circuit Inhibited By Next-Generation Weight Loss Drugs

Glucagon-like peptide-1 receptor agonists (GLP1RAs) effectively reduce body weight and improve metabolic outcomes, yet established peptide-based therapies require injections and complex manufacturi...

biorxiv.org
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GLP-1 receptor agonists (GLP-1RAs) are transforming the treatment of obesity and diabetes (and more). Our recent pre-print examined next-gen small molecules mimicking GLP-1, using humanized mouse models to uncover how they interact with brain circuits driving food consumption. 1/
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🚨 neuroscience tenure track faculty openings in the Department of Biology at the University of Virginia! Application review begins Oct. 4th
John Campbell@AUGCsoup4 Sep 2024
Love cutting-edge neuroscience, a highly interdisciplinary & collaborative department, & a beautiful college town near mountains? Join us in UVa’s Biology Dept! Now hiring neuroscientists for multiple TT Asst Prof positions. Review starts 10/4. Please RT! apply.interfolio.com/153064
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Come be my colleague! Application review begins on Oct 4! Make sure to have your materials submitted by then to be among the first future faculty we get to learn about. @UVA_PFN @uvabio @UVA_Brain
Dr. Sarah Kucenas@DrGlia184 Sep 2024
🚨Neuroscience job alert! The Dept of Biology at UVA is searching for multiple TT faculty in Neuroscience. If you're looking for a vibrant scientific community with wonderful colleagues, then apply! Please share/rt! apply.interfolio.com/153064 @UVA_PFN @uvabio @UVA_Brain @uvavpr
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Mice are obsessed with palatable high-fat diet, devaluing standard chow even when super hungry. Our latest work shows this is dependent on the amount and type of fat, experience, and post-ingestive feedback thru fat absorption, not taste or smell. gcc02.safelinks.protection.o…
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🚨Neuroscience job alert! The Dept of Biology at UVA is searching for multiple TT faculty in Neuroscience. If you're looking for a vibrant scientific community with wonderful colleagues, then apply! Please share/rt! apply.interfolio.com/153064 @UVA_PFN @uvabio @UVA_Brain @uvavpr
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Love cutting-edge neuroscience, a highly interdisciplinary & collaborative department, & a beautiful college town near mountains? Join us in UVa’s Biology Dept! Now hiring neuroscientists for multiple TT Asst Prof positions. Review starts 10/4. Please RT! apply.interfolio.com/153064
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🚨 Neuroscience job alert!! UVA Biology is hiring multiple TT faculty in Neuroscience (circuitry, glia, behavioral genetics, etc.). If you're looking for a vibrant scientific community with wonderful colleagues then check it out! Please share/rt! apply.interfolio.com/153064
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Güler Lab retweeted
Biyu Jade He@BiyuHe2 Sep 2024
My department is conducting a new faculty search in computational neuroscience, broadly defined. Please help spread the word!
Neuroscience at NYU Langone Health@NYULH_Neuro30 Aug 2024
🚨Faculty Job Alert! 🚨We are excited to announce a new tenure-track faculty search at the Neuroscience Institute for a #theoretical and/or #computational neuroscientist. Apply by 11/15 to join our community! apply.interfolio.com/153167 #neuroscience #academicjobs
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Güler Lab retweeted
Cody J. Smith@cssmity2 Sep 2024
The University of Notre Dame is hiring a cluster of 5 new Assistant Professors in Neuroscience starting this year, focused on cellular, molecular, or computational neurobiology. Come be a colleague! More information here: apply.interfolio.com/152596 Please share and retweet!
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Interested in the biology of GLP-1 in the nervous system? Where is it made, how does it work, endogenous physiology vs. pharmacology? Therapeutic potential? Coming up in September A workshop, register here @theNASEM #Parkinsonsdisease #Alzheimersdisease nationalacademies.org/event/…
Daniel J Drucker@DanielJDrucker30 Aug 2024
GLP-1RAs are neuroprotective in most preclinical studies. Here we detect robust glucose control & #weightloss yet no reduction in plaque, hippocampal IBA1 or GFAP + cells nor cytokine expression with semaglutide or tirzepatide in APP/S1 and 5XFAD mice sciencedirect.com/science/ar…
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We're Hiring! Assistant Professor of Biochemistry, Biophysics, and Structural Biology in MCB. Learn more and apply online: aprecruit.berkeley.edu/JPF04…
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GLP-1RAs are neuroprotective in most preclinical studies. Here we detect robust glucose control & #weightloss yet no reduction in plaque, hippocampal IBA1 or GFAP + cells nor cytokine expression with semaglutide or tirzepatide in APP/S1 and 5XFAD mice sciencedirect.com/science/ar…
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