@AliDGuler

Dad, husband, member of the @Gulerlab. ☘️🐦‍⬛ https://xitter.cf/t.co/I9kmtfYOYQ

 Charlottesville, VA
uva.theopenscholar.com/ali-guler
Joined March 2020
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GLP-1 receptor agonists (GLP-1RAs) are transforming the treatment of obesity and diabetes (and more). Our recent pre-print examined next-gen small molecules mimicking GLP-1, using humanized mouse models to uncover how they interact with brain circuits driving food consumption. 1/
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Ali D. Güler retweeted
nature
@NatureMay 12
Nature research paper: A brain reward circuit inhibited by next-generation weight-loss drugs in mice go.nature.com/4uUbvuX

A brain reward circuit inhibited by next-generation weight-loss drugs in mice

Nature - Humanized glucagon-like peptide 1 receptor (GLP1R) mouse models are used to investigate the neural circuitry through which small-molecule GLP1R agonists modulate feeding, with implications...

nature.com
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Ali D. Güler retweeted
Waggoner Lab@LabWaggonerMay 7
A neural circuit through which small-molecule GLP1RAs modulate reward processing, with implications for the treatment of substance-use disorder and binge eating @Nature @deppmann @GulerLab @LizzieGodschall @bugragungul @isabellesajonia @UVA nature.com/articles/s41586-0…
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Ali D. Güler retweeted
NIH
@NIHMay 6
NEWS: Oral small-molecule GLP-1 drugs penetrate deep into the brain to suppress cravings. 🧠 Read the full story ➡️ nih.gov/news-events/news-rel…

Oral small-molecule GLP-1 drugs penetrate deep into the brain to suppress cravings

NIH-funded research identifies new mechanism of action for next-generation weight-loss drugs.

nih.gov
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Now out in peer-reviewed form: nature.com/articles/s41586-0…

A brain reward circuit inhibited by next-generation weight-loss drugs in mice

Nature - Humanized glucagon-like peptide 1 receptor (GLP1R) mouse models are used to investigate the neural circuitry through which small-molecule GLP1R agonists modulate feeding, with implications...

nature.com
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A recent Northwestern Medicine study led by Lisa Beutler, MD, PhD, assistant professor of Medicine in the Division of Endocrinology, Metabolism and Molecular Medicine, identified novel neural circuits modulated by the diabetes and obesity medications semaglutide and tirzepatide that help suppress appetite. Hear Dr. Beutler explain these findings further: lnkd.in/g2pHhjxy
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Ali D. Güler retweeted
UVA Neuroscience@UVA_PFN4 Sep 2025
Replying to @AliDGuler @uvabio @UVA
Come and join us: neuroscience.virginia.edu/

Home

neuroscience.virginia.edu
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Ali D. Güler retweeted
Ali D. Güler@AliDGuler4 Sep 2025
At UVA, you’ll be part of a vibrant, collaborative neuroscience community spanning Biology, Medicine, Engineering, Data Science & more… in beautiful Charlottesville, VA. Apply today & help shape the future of neuroscience: apply.interfolio.com/172892 #Biology #UVA
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Ali D. Güler retweeted
Ali D. Güler@AliDGuler4 Sep 2025
We welcome applicants working on: • Neural circuits & plasticity • Glia & brain interactions • Behavioral genetics & genomics …and more! Join a highly interdisciplinary dept with access to state-of-the-art imaging, genomics, metabolomics, and computing resources. #NeuroJobs
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Ali D. Güler retweeted
Ali D. Güler@AliDGuler4 Sep 2025
We’re hiring! @uvabio @UVA_PFN @UVA UVA Biology is recruiting multiple tenure-track Assistant Professors in neuroscience as part of a $75M Brain & Neuroscience Initiative. Apply by Oct 15, 2025. Start Aug 2026. apply.interfolio.com/172892 #Neuroscience #FacultyJobs
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We’re hiring! @uvabio @UVA_PFN @UVA UVA Biology is recruiting multiple tenure-track Assistant Professors in neuroscience as part of a $75M Brain & Neuroscience Initiative. Apply by Oct 15, 2025. Start Aug 2026. apply.interfolio.com/172892 #Neuroscience #FacultyJobs
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We welcome applicants working on: • Neural circuits & plasticity • Glia & brain interactions • Behavioral genetics & genomics …and more! Join a highly interdisciplinary dept with access to state-of-the-art imaging, genomics, metabolomics, and computing resources. #NeuroJobs
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At UVA, you’ll be part of a vibrant, collaborative neuroscience community spanning Biology, Medicine, Engineering, Data Science & more… in beautiful Charlottesville, VA. Apply today & help shape the future of neuroscience: apply.interfolio.com/172892 #Biology #UVA
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LUKE KORNET TONIGHT — 10 POINTS 9 REBOUNDS 7 BLOCKS 100% FG GAME OF HIS LIFE. 🔥🔥🔥🔥
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Take the leap, it's easy bsky.app/
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A dedicated neural circuit through which small molecule GLP1RAs modulate reward processing, suggesting broad therapeutic potential in conditions of dysregulated dopamine signaling including substance use disorder and binge eating pubmed.ncbi.nlm.nih.gov/3976…
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Our collaborative team at UVA Biology Department @uvabio including the labs of Chris Deppmann @deppmann and John Campbell @AUGCsoup are awesome. They all made it fun!
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It turns out today is the humanized "Glp1rS33W" rodent model day. Here is another one published today by Eli Lilly and Company @EliLillyandCo science.org/doi/10.1126/scit… Didn't know... we could have had a party 😉🥳🎉

The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron

Studies reveal pharmacological characteristics for activating the GLP-1 receptor with a nonpeptide agonist.

science.org
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