PhD in Neuroscience | Postdoctoral Fellow at Harvard Medical School
Boston, MA
Joined October 2022
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T. Bugra Gungul retweeted
Nature research paper: A brain reward circuit inhibited by next-generation weight-loss drugs in mice
go.nature.com/4uUbvuX
T. Bugra Gungul retweeted
Out in Nature today: how next-gen GLP-1 drugs cut cravings, not just hunger.
Congrats to co-first authors Lizzie, Bugra, and Isabelle in @GulerLab lab traced the circuit — drug → central amygdala → less dopamine in reward circuits. Mostly Ali's lab; we got to contribute. Proud of this team.
rdcu.be/fhfOm
#neuroscience #UVA
T. Bugra Gungul retweeted
Discovery of a new brain reward circuit in the amygdala for small molecule (pill) GLP-1 drug effect, unlike the injectables (hypothalamus), as shown in mice
nature.com/articles/s41586-0…
T. Bugra Gungul retweeted
NEWS: Oral small-molecule GLP-1 drugs penetrate deep into the brain to suppress cravings. 🧠
Read the full story ➡️ nih.gov/news-events/news-rel…
T. Bugra Gungul retweeted
(1/n) Why is it so hard to stop eating when something tastes amazing? Our new @ScienceMagazine paper reveals that dopamine helps sustain our drive for tasty treats—and may explain how anti-obesity Ozempic tames those urges doi.org/10.1126/science.adt0…
Excited to share two big highlights from my research journey!
My abstract “A Brain Reward Circuit Inhibited by Next-Generation Weight Loss Drugs” was chosen for an SfN press conference — <50 selected out of 10,000+! We’ll be sharing our work to the media this November.
Also, next week I’ll present at GRC on catecholamines: molecular, circuit, behavior & brain disorders — joining top scientists to discuss neuromodulatory systems.
Grateful to share our work with the scientific community & the public — and to our amazing team: Elizabeth Godschall, Isabelle Sajonia, my PI @AliDGuler & collaborators @deppmann @AUGCsoup
T. Bugra Gungul retweeted
A dedicated neural circuit through which small molecule GLP1RAs modulate reward processing, suggesting broad therapeutic potential in conditions of dysregulated dopamine signaling including substance use disorder and binge eating
pubmed.ncbi.nlm.nih.gov/3976…
T. Bugra Gungul retweeted
You can read more about it here: biorxiv.org/content/10.1101/… Send us feedback on how we can improve our manuscript. All this work was led by three very talented graduate students: Lizzie Godschall @LizzieGodschall, Buğra Güngül @bugragungul and Isabelle Sajonia @isabellesajonia. 15/
T. Bugra Gungul retweeted
GLP-1 receptor agonists (GLP-1RAs) are transforming the treatment of obesity and diabetes (and more). Our recent pre-print examined next-gen small molecules mimicking GLP-1, using humanized mouse models to uncover how they interact with brain circuits driving food consumption. 1/
Neurons in the central amygdala just threw the ultimate glow-up party! They brighthened my day 🎉🧠
Image credit: @LizzieGodschall
Our article from Master’s studies has been published today! Here we used metabolome-wide screening to assess changes during PTEN-loss in hormone-refractory cancers and proposed potential combinatorial therapies. Congrats to all authors! @kaysudic
onlinelibrary.wiley.com/doi/…
